Slc5a12 solute carrier family 5 (sodium/glucose cotransporter), member 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc5a12provided by MGI
Official Full Name: solute carrier family 5 (sodium/glucose cotransporter), member 12provided by MGI
Primary source: MGI:MGI:2138890
See related: Ensembl:ENSMUSG00000041644 AllianceGenome:MGI:2138890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SMCT2; D630015G19
Summary: Enables lactate transmembrane transporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within ion transport. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SLC5A12 (solute carrier family 5 member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward kidney adult (RPKM 48.3) See more
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 56.75 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (110427644..110479690)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (110597299..110649345)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring.
Title: Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring.
A low affinity type of SMCT2-like transporter is in operation with high capacity throughout the small intestine, playing the role as the major intestinal nicotinate uptake transporter.
Title: Nicotinate uptake by two kinetically distinct Na÷-dependent carrier-mediated transport systems in the rat small intestine.
SMCT2 was localized in the brush border of enterocytes in the intestinal villi, and SMCT2 was localized in the brush border of is a jejunal type of SCMT.
Title: The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract.
low-affinity transporter SMCT2 initiates lactate absorption in the early parts of the proximal tubule followed by the participation of the high-affinity transporter SMCT1 in the latter parts of the proximal tubule.
Title: Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney.
These data provide the first evidence for the expression of SMCT1 and SMCT2 in the retina and for the cell-type specific distribution of these transporters within the retina.
Title: Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina.
slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice have a role in the renal handling of lactate and urate
Title: c/ebpdelta Null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney.
The cloning and characterization of slc5a12 (SMCT2) is reported.
Title: Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)

General gene information

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Markers

AI315119 (e-PCR)
- UniSTS:158997

AI481121 (e-PCR)
- UniSTS:158999

Slc5a12 (e-PCR), detects polymorphism
- UniSTS:547128

RH127605 (e-PCR)
- UniSTS:210915

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lactate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-coupled monocarboxylate transporter 2

Names: electroneutral sodium monocarboxylate cotransporter; low-affinity sodium-lactate cotransporter; sodium solute cotransporter; solute carrier family 5 member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003915.2 → NP_001003915.1 sodium-coupled monocarboxylate transporter 2 isoform 1

See identical proteins and their annotated locations for NP_001003915.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL732495, BX005257

Consensus CDS

CCDS16512.1

UniProtKB/Swiss-Prot

Q49B93

Related

ENSMUSP00000047340.7, ENSMUST00000045972.13

Conserved Domains (1) summary

cl00456
Location:3 → 531

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_001177624.1 → NP_001171095.1 sodium-coupled monocarboxylate transporter 2 isoform 2

See identical proteins and their annotated locations for NP_001171095.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AK165419, AL732495, BX005257

Consensus CDS

CCDS50656.1

UniProtKB/Swiss-Prot

Q0D2G1, Q49B93, Q6A4K8

UniProtKB/TrEMBL

B9EJ03

Related

ENSMUSP00000106655.3, ENSMUST00000111026.3

Conserved Domains (1) summary

cd11520
Location:3 → 527

SLC5sbd_SMCT2; Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

110427644..110479690

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499489.4 → XP_006499552.1 sodium-coupled monocarboxylate transporter 2 isoform X1

Conserved Domains (1) summary

cl00456
Location:1 → 339

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain