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    LIMCH1 LIM and calponin homology domains 1 [ Homo sapiens (human) ]

    Gene ID: 22998, updated on 7-Apr-2024

    Summary

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    Official Symbol
    LIMCH1provided by HGNC
    Official Full Name
    LIM and calponin homology domains 1provided by HGNC
    Primary source
    HGNC:HGNC:29191
    See related
    Ensembl:ENSG00000064042 MIM:617750; AllianceGenome:HGNC:29191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LMO7B; LIMCH1A
    Summary
    Enables myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in stress fiber. Colocalizes with myosin II complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung (RPKM 19.3), spleen (RPKM 14.7) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4p13
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (41359607..41700044)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (41333394..41673808)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (41361624..41702061)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr4:41244640-41244866 Neighboring gene UCHL1 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:41259655-41260155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:41290173-41290673 Neighboring gene ubiquitin C-terminal hydrolase L1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:41329658-41330318 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:41364841-41365502 Neighboring gene ribosomal protein L12 pseudogene 20 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:41434604-41435306 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:41435307-41436010 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:41527060-41527659 Neighboring gene uncharacterized LOC105374423 Neighboring gene uncharacterized LOC105374421 Neighboring gene paired like homeobox 2b polyalanine repeat instability region Neighboring gene olfactory receptor family 5 subfamily M member 14 pseudogene Neighboring gene PHOX2B antisense RNA 1 Neighboring gene paired like homeobox 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LIMCH1 as a New Potential Metastasis Predictor in Breast Cancer. Alifanov VV, et al. Asian Pac J Cancer Prev, 2022 Nov 1. PMID 36444609, Free PMC Article
    2. A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease. Halle MK, et al. Br J Cancer, 2021 May. PMID 33723390, Free PMC Article
    3. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Bersini S, et al. Life Sci Alliance, 2020 Jan. PMID 31959624, Free PMC Article
    4. LIMCH1 suppress the growth of lung cancer by interacting with HUWE1 to sustain p53 stability. Zhang Y, et al. Gene, 2019 Sep 5. PMID 31279706
    5. LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease. Karlsson T, et al. Lung Cancer, 2018 Nov. PMID 30429017

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIMCH1 as a New Potential Metastasis Predictor in Breast Cancer.
      Title: LIMCH1 as a New Potential Metastasis Predictor in Breast Cancer.
    2. A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease.
      Title: A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease.
    3. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.
      Title: Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.
    4. LMO7 and LIMCH1 co-localized and co-immunoprecipitated.
      Title: LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease.
    5. LIMCH1 is a negative regulator involved in a new molecular mechanism for the pathogenesis of lung cancer with HUWE1 and p53
      Title: LIMCH1 suppress the growth of lung cancer by interacting with HUWE1 to sustain p53 stability.
    6. Data suggest that LIMCH1 plays a positive role in regulation of NM-II activity through effects on MRLC during cell migration.
      Title: LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
    EBI GWAS Catalog
    Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43014, MGC72127, DKFZp434I0312, DKFZp686B2470, DKFZp686G2094, DKFZp781C1754, DKFZp781I1455, DKFZp686A01247, DKFZp686G18243

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin II head/neck binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin II head/neck binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin II head/neck binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic actin-based contraction involved in cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of focal adhesion assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin II complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LIM and calponin homology domains-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112717.4 → NP_001106188.1  LIM and calponin homology domains-containing protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AB029025, AC105389, AK026815, BX537916, CR749205, CR933645
      Consensus CDS
      CCDS54763.1
      UniProtKB/TrEMBL
      B7Z5Q8
      Related
      ENSP00000424645.1, ENST00000512946.5
      Conserved Domains (4) summary
      smart00132
      Location:987 → 1044
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd21278
      Location:23 → 140
      CH_LIMCH1; calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1
      pfam15949
      Location:250 → 418
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:771 → 808
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001112718.4 → NP_001106189.1  LIM and calponin homology domains-containing protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AB029025, AC105389, AK026815, BX537916, CR749205, CR936664
      Consensus CDS
      CCDS54764.1
      UniProtKB/TrEMBL
      B7Z5Q8
      Related
      ENSP00000424825.1, ENST00000508501.5
      Conserved Domains (4) summary
      smart00132
      Location:986 → 1043
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd21278
      Location:23 → 140
      CH_LIMCH1; calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1
      pfam15949
      Location:250 → 418
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:770 → 807
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_001112719.4 → NP_001106190.1  LIM and calponin homology domains-containing protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC105389, AK026815, BX537916, CR749205, CR936661
      Consensus CDS
      CCDS47047.1
      UniProtKB/TrEMBL
      B7Z5Q8
      Related
      ENSP00000379840.3, ENST00000396595.7
      Conserved Domains (3) summary
      smart00132
      Location:832 → 889
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam15949
      Location:96 → 264
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:616 → 653
      GBP_C; Guanylate-binding protein, C-terminal domain

    4. NM_001112720.4 → NP_001106191.1  LIM and calponin homology domains-containing protein 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding region, uses an alternate in-frame splice site, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC105389, AK026815, BX537916, CR749205, CR936664, DA786971
      Consensus CDS
      CCDS54765.1
      UniProtKB/TrEMBL
      B7Z5Q8
      Related
      ENSP00000371172.4, ENST00000381753.8
      Conserved Domains (3) summary
      smart00132
      Location:820 → 877
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam15949
      Location:96 → 252
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:604 → 641
      GBP_C; Guanylate-binding protein, C-terminal domain

    5. NM_001289122.3 → NP_001276051.1  LIM and calponin homology domains-containing protein 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AB029025, AK026815, BX537916, CR749205, CR936601, CR936658
      Consensus CDS
      CCDS75119.1
      UniProtKB/TrEMBL
      B7Z5Q8
      Related
      ENSP00000424437.1, ENST00000512820.5
      Conserved Domains (5) summary
      pfam06390
      Location:608 → 813
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00132
      Location:999 → 1056
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:250 → 405
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:783 → 820
      GBP_C; Guanylate-binding protein, C-terminal domain

    6. NM_001289124.2 → NP_001276053.1  LIM and calponin homology domains-containing protein 1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AK026815, BX537916, CR749205, CR936601, CR936610
      Consensus CDS
      CCDS75121.1
      UniProtKB/TrEMBL
      B7Z5Q8
      Related
      ENSP00000425222.1, ENST00000513024.5
      Conserved Domains (3) summary
      smart00132
      Location:840 → 897
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam15949
      Location:91 → 246
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:624 → 661
      GBP_C; Guanylate-binding protein, C-terminal domain

    7. NM_001330672.2 → NP_001317601.1  LIM and calponin homology domains-containing protein 1 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream start codon and multiple internal differences, including a large novel segment. The resulting isoform (h) has a longer overall length, but has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AB029025, AC105389, AC108050, AC124009, AK026815, AL831962, BX537916, CR749205, DC325132
      Consensus CDS
      CCDS82919.1
      UniProtKB/TrEMBL
      G5EA03
      Related
      ENSP00000425631.1, ENST00000503057.6
      Conserved Domains (3) summary
      smart00132
      Location:1397 → 1454
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam15949
      Location:654 → 802
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1155 → 1192
      GBP_C; Guanylate-binding protein, C-terminal domain

    8. NM_001330674.2 → NP_001317603.1  LIM and calponin homology domains-containing protein 1 isoform i

      Status: VALIDATED

      Source sequence(s)
      AK026815, AK294774, AK299835, BX537916, CR749205, CR936658
      Consensus CDS
      CCDS82920.1
      UniProtKB/TrEMBL
      B7Z2J4, E9PDJ9
      Related
      ENSP00000422864.1, ENST00000509277.5
      Conserved Domains (3) summary
      smart00132
      Location:846 → 903
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam15949
      Location:96 → 251
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:604 → 641
      GBP_C; Guanylate-binding protein, C-terminal domain

    9. NM_001330784.2 → NP_001317713.1  LIM and calponin homology domains-containing protein 1 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC105389, AC108050, AK026815, BX537916, CR749205, CR936658
      Consensus CDS
      CCDS87221.1
      UniProtKB/TrEMBL
      B7Z5Q8, D6RD46
      Related
      ENSP00000427045.1, ENST00000512632.5

    10. NM_001330786.2 → NP_001317715.1  LIM and calponin homology domains-containing protein 1 isoform k

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) represents use of an alternate promoter and initiates translation at a downstream start codon compared to variant 1.
      Source sequence(s)
      AC105389, AK026815, BC023546, BX537916, CR749205, DC325132
      Consensus CDS
      CCDS87222.1
      UniProtKB/TrEMBL
      B7Z5Q8
      Related
      ENSP00000421242.1, ENST00000511496.5

    11. NM_001330787.2 → NP_001317716.1  LIM and calponin homology domains-containing protein 1 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC095043, AC105389, AC108050, AC124009
      UniProtKB/TrEMBL
      H0Y8P3

    12. NM_001330788.2 → NP_001317717.1  LIM and calponin homology domains-containing protein 1 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC095043, AC105389, AC108050, AC124009
      UniProtKB/TrEMBL
      H0Y8P3

    13. NM_001330789.2 → NP_001317718.1  LIM and calponin homology domains-containing protein 1 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC095043, AC105389, AC108050, AC124009
      UniProtKB/TrEMBL
      B7Z5Q8

    14. NM_001330790.2 → NP_001317719.1  LIM and calponin homology domains-containing protein 1 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC095043, AC105389, AC108050, AC124009
      UniProtKB/TrEMBL
      H0Y8P3

    15. NM_001330791.2 → NP_001317720.1  LIM and calponin homology domains-containing protein 1 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC095043, AC105389, AC108050
      UniProtKB/TrEMBL
      B7Z2J4
      Conserved Domains (4) summary
      smart00132
      Location:1000 → 1057
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:250 → 405
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:758 → 795
      GBP_C; Guanylate-binding protein, C-terminal domain

    16. NM_001330792.2 → NP_001317721.1  LIM and calponin homology domains-containing protein 1 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC095043, AC105389, AC108050
      UniProtKB/TrEMBL
      B7Z5Q8
      Conserved Domains (4) summary
      smart00132
      Location:974 → 1031
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:250 → 405
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:758 → 795
      GBP_C; Guanylate-binding protein, C-terminal domain

    17. NM_001330793.2 → NP_001317722.1  LIM and calponin homology domains-containing protein 1 isoform r

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AC105389, AC108050, AC124009
      UniProtKB/TrEMBL
      H0Y8P3
      Related
      ENSP00000421656.1, ENST00000508466.1

    18. NM_001330982.2 → NP_001317911.1  LIM and calponin homology domains-containing protein 1 isoform s

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AC105389, AC108050, AC124009
      UniProtKB/TrEMBL
      B7Z5Q8

    19. NM_001330983.1 → NP_001317912.1  LIM and calponin homology domains-containing protein 1 isoform t

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AC105389, AC108050, AC124009
      UniProtKB/TrEMBL
      H0Y8P3
      Conserved Domains (3) summary
      smart00132
      Location:861 → 918
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam15949
      Location:96 → 263
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:616 → 653
      GBP_C; Guanylate-binding protein, C-terminal domain

    20. NM_014988.5 → NP_055803.2  LIM and calponin homology domains-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_055803.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (a).
      Source sequence(s)
      AB029025, AC105389, AK026815, BX537916, CR749205
      Consensus CDS
      CCDS33977.1
      UniProtKB/Swiss-Prot
      A8MXC3, E9PHM7, Q503B5, Q5CZB1, Q5CZB6, Q5H9S8, Q68E07, Q6PJ44, Q7Z3G5, Q8N3S9, Q8N6M2, Q9UPQ0
      UniProtKB/TrEMBL
      H0Y8P3
      Related
      ENSP00000316891.7, ENST00000313860.12
      Conserved Domains (4) summary
      smart00132
      Location:1013 → 1070
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:250 → 417
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:771 → 808
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      41359607..41700044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513642.2 → XP_011511944.1  LIM and calponin homology domains-containing protein 1 isoform X1

      Conserved Domains (4) summary
      smart00132
      Location:1585 → 1642
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1340 → 1377
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_011513644.2 → XP_011511946.1  LIM and calponin homology domains-containing protein 1 isoform X3

      Conserved Domains (4) summary
      smart00132
      Location:1582 → 1639
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1340 → 1377
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. XM_011513646.2 → XP_011511948.1  LIM and calponin homology domains-containing protein 1 isoform X10

      Conserved Domains (4) summary
      smart00132
      Location:1556 → 1613
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1340 → 1377
      GBP_C; Guanylate-binding protein, C-terminal domain

    4. XM_011513643.2 → XP_011511945.1  LIM and calponin homology domains-containing protein 1 isoform X2

      Conserved Domains (4) summary
      smart00132
      Location:1584 → 1641
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1339 → 1376
      GBP_C; Guanylate-binding protein, C-terminal domain

    5. XM_017007894.2 → XP_016863383.1  LIM and calponin homology domains-containing protein 1 isoform X4

    6. XM_047449833.1 → XP_047305789.1  LIM and calponin homology domains-containing protein 1 isoform X11

    7. XM_011513645.2 → XP_011511947.1  LIM and calponin homology domains-containing protein 1 isoform X8

      Conserved Domains (3) summary
      smart00132
      Location:1557 → 1614
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)

    8. XM_017007896.2 → XP_016863385.1  LIM and calponin homology domains-containing protein 1 isoform X15

    9. XM_005248057.2 → XP_005248114.1  LIM and calponin homology domains-containing protein 1 isoform X5

      Conserved Domains (4) summary
      smart00132
      Location:1560 → 1617
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1315 → 1352
      GBP_C; Guanylate-binding protein, C-terminal domain

    10. XM_017007895.2 → XP_016863384.1  LIM and calponin homology domains-containing protein 1 isoform X7

    11. XM_047449834.1 → XP_047305790.1  LIM and calponin homology domains-containing protein 1 isoform X13

    12. XM_005248058.2 → XP_005248115.1  LIM and calponin homology domains-containing protein 1 isoform X6

      Conserved Domains (4) summary
      smart00132
      Location:1559 → 1616
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1314 → 1351
      GBP_C; Guanylate-binding protein, C-terminal domain

    13. XM_005248060.2 → XP_005248117.1  LIM and calponin homology domains-containing protein 1 isoform X9

      Conserved Domains (4) summary
      smart00132
      Location:1556 → 1613
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1314 → 1351
      GBP_C; Guanylate-binding protein, C-terminal domain

    14. XM_006713996.2 → XP_006714059.1  LIM and calponin homology domains-containing protein 1 isoform X14

      Conserved Domains (4) summary
      smart00132
      Location:1530 → 1587
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:1314 → 1351
      GBP_C; Guanylate-binding protein, C-terminal domain

    15. XM_005248061.2 → XP_005248118.1  LIM and calponin homology domains-containing protein 1 isoform X12

      Conserved Domains (3) summary
      smart00132
      Location:1532 → 1589
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:813 → 961
      DUF4757; Domain of unknown function (DUF4757)

    16. XM_011513653.2 → XP_011511955.1  LIM and calponin homology domains-containing protein 1 isoform X16

      UniProtKB/TrEMBL
      H0Y8P3
      Conserved Domains (4) summary
      smart00132
      Location:1041 → 1098
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:250 → 417
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:796 → 833
      GBP_C; Guanylate-binding protein, C-terminal domain

    17. XM_047449835.1 → XP_047305791.1  LIM and calponin homology domains-containing protein 1 isoform X19

    18. XM_017007898.2 → XP_016863387.1  LIM and calponin homology domains-containing protein 1 isoform X18

      UniProtKB/TrEMBL
      H0Y8P3

    19. XM_017007900.2 → XP_016863389.1  LIM and calponin homology domains-containing protein 1 isoform X24

      UniProtKB/TrEMBL
      H0Y8P3

    20. XM_011513654.2 → XP_011511956.1  LIM and calponin homology domains-containing protein 1 isoform X17

      UniProtKB/TrEMBL
      B7Z2J4
      Conserved Domains (4) summary
      smart00132
      Location:1029 → 1086
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:250 → 405
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:784 → 821
      GBP_C; Guanylate-binding protein, C-terminal domain

    21. XM_047449838.1 → XP_047305794.1  LIM and calponin homology domains-containing protein 1 isoform X23

    22. XM_024453937.2 → XP_024309705.1  LIM and calponin homology domains-containing protein 1 isoform X20

      UniProtKB/TrEMBL
      B7Z2J4
      Conserved Domains (4) summary
      smart00132
      Location:1004 → 1061
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      cd00014
      Location:26 → 138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam15949
      Location:250 → 406
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:759 → 796
      GBP_C; Guanylate-binding protein, C-terminal domain

    23. XM_047449837.1 → XP_047305793.1  LIM and calponin homology domains-containing protein 1 isoform X22

    24. XM_047449840.1 → XP_047305796.1  LIM and calponin homology domains-containing protein 1 isoform X26

    25. XM_047449836.1 → XP_047305792.1  LIM and calponin homology domains-containing protein 1 isoform X21

    26. XM_047449839.1 → XP_047305795.1  LIM and calponin homology domains-containing protein 1 isoform X25

    27. XM_047449841.1 → XP_047305797.1  LIM and calponin homology domains-containing protein 1 isoform X27

    28. XM_017007903.2 → XP_016863392.1  LIM and calponin homology domains-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      H0Y8P3

    29. XM_047449842.1 → XP_047305798.1  LIM and calponin homology domains-containing protein 1 isoform X30

    30. XM_024453938.2 → XP_024309706.1  LIM and calponin homology domains-containing protein 1 isoform X33

      UniProtKB/TrEMBL
      B7Z5Q8
      Conserved Domains (2) summary
      smart00132
      Location:805 → 862
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam15949
      Location:96 → 264
      DUF4757; Domain of unknown function (DUF4757)

    31. XM_011513655.2 → XP_011511957.1  LIM and calponin homology domains-containing protein 1 isoform X29

      UniProtKB/TrEMBL
      B7Z2J4
      Conserved Domains (3) summary
      smart00132
      Location:875 → 932
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam15949
      Location:96 → 251
      DUF4757; Domain of unknown function (DUF4757)
      cl20817
      Location:630 → 667
      GBP_C; Guanylate-binding protein, C-terminal domain

    32. XM_047449843.1 → XP_047305799.1  LIM and calponin homology domains-containing protein 1 isoform X31

    33. XM_047449844.1 → XP_047305800.1  LIM and calponin homology domains-containing protein 1 isoform X32

    34. XM_047449845.1 → XP_047305801.1  LIM and calponin homology domains-containing protein 1 isoform X34

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      41333394..41673808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349282.1 → XP_054205257.1  LIM and calponin homology domains-containing protein 1 isoform X1

    2. XM_054349284.1 → XP_054205259.1  LIM and calponin homology domains-containing protein 1 isoform X3

    3. XM_054349291.1 → XP_054205266.1  LIM and calponin homology domains-containing protein 1 isoform X10

    4. XM_054349283.1 → XP_054205258.1  LIM and calponin homology domains-containing protein 1 isoform X2

    5. XM_054349285.1 → XP_054205260.1  LIM and calponin homology domains-containing protein 1 isoform X4

    6. XM_054349292.1 → XP_054205267.1  LIM and calponin homology domains-containing protein 1 isoform X11

    7. XM_054349289.1 → XP_054205264.1  LIM and calponin homology domains-containing protein 1 isoform X8

    8. XM_054349296.1 → XP_054205271.1  LIM and calponin homology domains-containing protein 1 isoform X15

    9. XM_054349286.1 → XP_054205261.1  LIM and calponin homology domains-containing protein 1 isoform X5

    10. XM_054349288.1 → XP_054205263.1  LIM and calponin homology domains-containing protein 1 isoform X7

    11. XM_054349294.1 → XP_054205269.1  LIM and calponin homology domains-containing protein 1 isoform X13

    12. XM_054349287.1 → XP_054205262.1  LIM and calponin homology domains-containing protein 1 isoform X6

    13. XM_054349290.1 → XP_054205265.1  LIM and calponin homology domains-containing protein 1 isoform X9

    14. XM_054349295.1 → XP_054205270.1  LIM and calponin homology domains-containing protein 1 isoform X14

    15. XM_054349293.1 → XP_054205268.1  LIM and calponin homology domains-containing protein 1 isoform X12

    16. XM_054349297.1 → XP_054205272.1  LIM and calponin homology domains-containing protein 1 isoform X16

    17. XM_054349300.1 → XP_054205275.1  LIM and calponin homology domains-containing protein 1 isoform X19

    18. XM_054349299.1 → XP_054205274.1  LIM and calponin homology domains-containing protein 1 isoform X18

    19. XM_054349305.1 → XP_054205280.1  LIM and calponin homology domains-containing protein 1 isoform X24

    20. XM_054349298.1 → XP_054205273.1  LIM and calponin homology domains-containing protein 1 isoform X17

    21. XM_054349304.1 → XP_054205279.1  LIM and calponin homology domains-containing protein 1 isoform X23

    22. XM_054349301.1 → XP_054205276.1  LIM and calponin homology domains-containing protein 1 isoform X20

    23. XM_054349303.1 → XP_054205278.1  LIM and calponin homology domains-containing protein 1 isoform X22

    24. XM_054349307.1 → XP_054205282.1  LIM and calponin homology domains-containing protein 1 isoform X26

    25. XM_054349302.1 → XP_054205277.1  LIM and calponin homology domains-containing protein 1 isoform X21

    26. XM_054349306.1 → XP_054205281.1  LIM and calponin homology domains-containing protein 1 isoform X25

    27. XM_054349308.1 → XP_054205283.1  LIM and calponin homology domains-containing protein 1 isoform X27

    28. XM_054349309.1 → XP_054205284.1  LIM and calponin homology domains-containing protein 1 isoform X28

    29. XM_054349311.1 → XP_054205286.1  LIM and calponin homology domains-containing protein 1 isoform X30

    30. XM_054349314.1 → XP_054205289.1  LIM and calponin homology domains-containing protein 1 isoform X33

    31. XM_054349310.1 → XP_054205285.1  LIM and calponin homology domains-containing protein 1 isoform X29

    32. XM_054349312.1 → XP_054205287.1  LIM and calponin homology domains-containing protein 1 isoform X31

    33. XM_054349313.1 → XP_054205288.1  LIM and calponin homology domains-containing protein 1 isoform X32

    34. XM_054349315.1 → XP_054205290.1  LIM and calponin homology domains-containing protein 1 isoform X34

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UPQ0.4 GenPept UniProtKB/Swiss-Prot:Q9UPQ0

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