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Clu clusterin [ Mus musculus (house mouse) ]

Gene ID: 12759, updated on 9-May-2015
Official Symbol
Cluprovided by MGI
Official Full Name
clusterinprovided by MGI
Primary source
MGI:MGI:88423
See related
Ensembl:ENSMUSG00000022037; Vega:OTTMUSG00000032654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cli; ApoJ; Sgp2; SP-40; Sgp-2; Sugp-2; AI893575; D14Ucla3
Summary
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]
Orthologs
See Clu in MapViewer
Location:
14 D1; 14 34.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 14 NC_000080.6 (65968483..65981547)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66587320..66600382)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41182 Neighboring gene scavenger receptor class A, member 3 Neighboring gene protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform pseudogene Neighboring gene gulonolactone (L-) oxidase Neighboring gene a disintegrin and metallopeptidase domain 2 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
misfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell death IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
central nervous system myelin maintenance ISO
Inferred from Sequence Orthology
more info
 
chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
endocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
microglial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of beta-amyloid formation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of beta-amyloid formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurofibrillary tangle assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
protein import ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of beta-amyloid clearance ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
regulation of neuronal signal transduction ISO
Inferred from Sequence Orthology
more info
 
response to misfolded protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
aggresome ISO
Inferred from Sequence Orthology
more info
 
apical dendrite ISO
Inferred from Sequence Orthology
more info
 
blood microparticle ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neurofibrillary tangle ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
spherical high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
clusterin
Names
clusterin
Apolipoprotein J
apo-J
clustrin
complement lysis inhibitor
sulfated glycoprotein 2
testosterone repressed prostate message
testosterone repressed prostate message-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013492.2NP_038520.2  clusterin precursor

    See identical proteins and their annotated locations for NP_038520.2

    Status: VALIDATED

    Source sequence(s)
    BC075668, BY248781, CK623407
    Consensus CDS
    CCDS36957.1
    UniProtKB/Swiss-Prot
    Q06890
    UniProtKB/TrEMBL
    Q549A5
    Related
    ENSMUSP00000022616, OTTMUSP00000043417, ENSMUST00000022616, OTTMUST00000081231
    Conserved Domains (3) summary
    smart00030
    Location:22226
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:227442
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:28448
    Clusterin; Clusterin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p3 C57BL/6J

    Range
    65968483..65981547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518504.2XP_006518567.1  

    See identical proteins and their annotated locations for XP_006518567.1

    UniProtKB/Swiss-Prot
    Q06890
    UniProtKB/TrEMBL
    Q549A5
    Conserved Domains (3) summary
    smart00030
    Location:22226
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:227442
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:28448
    Clusterin; Clusterin
  2. XM_006518503.2XP_006518566.1  

    Conserved Domains (3) summary
    smart00030
    Location:32236
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:237452
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:38458
    Clusterin; Clusterin

Alternate Mm_Celera

Genomic

  1. AC_000036.1 Alternate Mm_Celera

    Range
    51264543..51272775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)