Stat1 signal transducer and activator of transcription 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stat1provided by MGI
Official Full Name: signal transducer and activator of transcription 1provided by MGI
Primary source: MGI:MGI:103063
See related: Ensembl:ENSMUSG00000026104 AllianceGenome:MGI:103063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010005J02Rik
Summary: Enables DNA-binding transcription factor activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and defense response to other organism. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of macrophage fusion; and response to exogenous dsRNA. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skeletal musculature. Used to study breast cancer and severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; immunodeficiency 31C; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 23.3), spleen adult (RPKM 19.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 26.81 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (52158588..52201024)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (52119438..52161865)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-gamma signaling in squamous cancer.
Title: Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer.
STAT1 Employs Myeloid Cell-Extrinsic Mechanisms to Regulate the Neutrophil Response and Provide Protection against Invasive Klebsiella pneumoniae Lung Infection.
Title: STAT1 Employs Myeloid Cell-Extrinsic Mechanisms to Regulate the Neutrophil Response and Provide Protection against Invasive Klebsiella pneumoniae Lung Infection.
HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.
Title: HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.
Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
Title: Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6.
Title: PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6.
Acetyltransferases CBP/p300 Control Transcriptional Switch of beta-Catenin and Stat1 Promoting Osteoblast Differentiation.
Title: Acetyltransferases CBP/p300 Control Transcriptional Switch of β-Catenin and Stat1 Promoting Osteoblast Differentiation.
ETS2 overexpression ameliorates cartilage injury in osteoarthritis by the ETS2/miR-155/STAT1/DNMT1 feedback loop pathway.
Title: ETS2 overexpression ameliorates cartilage injury in osteoarthritis by the ETS2/miR-155/STAT1/DNMT1 feedback loop pathway.
Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling.
Title: Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling.
Cytoplasmic-delivery of polyinosine-polycytidylic acid inhibits pancreatic cancer progression increasing survival by activating Stat1-CCL2-mediated immunity.
Title: Cytoplasmic-delivery of polyinosine-polycytidylic acid inhibits pancreatic cancer progression increasing survival by activating Stat1-CCL2-mediated immunity.
IFNgamma-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.
Title: IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.

Submit: New GeneRIF Correction See all GeneRIFs (435)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (16) 1 citation
Chemically induced (ENU) (7) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Stat1 (e-PCR), detects polymorphism
- UniSTS:144512

RH124684 (e-PCR)
- UniSTS:161506

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR5 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in interleukin-27-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-9-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by virus of viral protein levels in host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macrophage fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in renal tubule development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to type I interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ISGF3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ISGF3 complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal transducer and activator of transcription 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205313.1 → NP_001192242.1 signal transducer and activator of transcription 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC123752, AK046517, BC042551, BX513160

Consensus CDS

CCDS78581.1

UniProtKB/TrEMBL

A0A087WSP5, Q8C8M3

Related

ENSMUSP00000141132.2, ENSMUST00000186057.7

Conserved Domains (5) summary

cd10372
Location:563 → 713

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:139 → 315

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:317 → 572

STAT_bind; STAT protein, DNA binding domain

pfam12162
Location:721 → 745

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001205314.1 → NP_001192243.1 signal transducer and activator of transcription 1 isoform 2

See identical proteins and their annotated locations for NP_001192243.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2, 3, and 4 encode the same isoform.

Source sequence(s)

AK039458, AK084855, BC042551, BX513160

Consensus CDS

CCDS56628.1

UniProtKB/TrEMBL

E9QK78, Q3TW11, Q8C3V4, Q9D323

Related

ENSMUSP00000140875.2, ENSMUST00000186857.7

Conserved Domains (5) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:715 → 739

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001357627.1 → NP_001344556.1 signal transducer and activator of transcription 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC123752

Consensus CDS

CCDS56628.1

UniProtKB/TrEMBL

E9QK78, Q3TW11, Q8C3V4, Q9D323

Conserved Domains (5) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:715 → 739

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_009283.4 → NP_033309.3 signal transducer and activator of transcription 1 isoform 2

See identical proteins and their annotated locations for NP_033309.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2, 3, and 4 encode the same isoform.

Source sequence(s)

AC123752, AK039458, AK082706, BC042551, BX513160

Consensus CDS

CCDS56628.1

UniProtKB/TrEMBL

E9QK78, Q3TW11, Q8C3V4, Q9D323

Related

ENSMUSP00000066743.8, ENSMUST00000070968.14

Conserved Domains (5) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:715 → 739

STAT1_TAZ2bind; STAT1 TAZ2 binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

52158588..52201024

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163078.1 → XP_036018971.1 signal transducer and activator of transcription 1 isoform X2

UniProtKB/TrEMBL

Q3TW11, Q8C497, Q99K94, Q9D323

Related

ENSMUSP00000140518.2, ENSMUST00000186574.7

Conserved Domains (4) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
XM_017319463.3 → XP_017174952.1 signal transducer and activator of transcription 1 isoform X1

UniProtKB/TrEMBL

E9QK78, Q3TW11, Q8C3V4, Q9D323

Conserved Domains (5) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:715 → 739

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
XM_030252467.2 → XP_030108327.1 signal transducer and activator of transcription 1 isoform X1

UniProtKB/TrEMBL

E9QK78, Q3TW11, Q8C3V4, Q9D323

Conserved Domains (5) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:715 → 739

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
XM_017319464.3 → XP_017174953.1 signal transducer and activator of transcription 1 isoform X1

UniProtKB/TrEMBL

E9QK78, Q3TW11, Q8C3V4, Q9D323

Conserved Domains (5) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:715 → 739

STAT1_TAZ2bind; STAT1 TAZ2 binding domain