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Dusp16 dual specificity phosphatase 16 [ Mus musculus (house mouse) ]

Gene ID: 70686, updated on 24-Jan-2015
Official Symbol
Dusp16provided by MGI
Official Full Name
dual specificity phosphatase 16provided by MGI
Primary source
MGI:MGI:1917936
See related
Ensembl:ENSMUSG00000030203; Vega:OTTMUSG00000023267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MKP7; Mkpm; MKP-7; AW558566; D6Ertd213e; 3830417M17Rik
Orthologs
See Dusp16 in MapViewer
Location:
6 G1; 6 65.77 cM
Exon count:
10
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 6 NC_000072.6 (134715468..134792628, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene MANSC domain containing 1 Neighboring gene loss of heterozygosity, 12, chromosomal region 1 homolog (human) Neighboring gene predicted gene, 36328 Neighboring gene predicted gene, 36269 Neighboring gene cAMP responsive element binding protein-like 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
inactivation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
dual specificity phosphatase 16
Names
dual specificity phosphatase 16
MAP kinase phosphatase-7
map kinase phosphatase-M

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048054.2NP_001041519.1  dual specificity phosphatase 16 isoform B1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B1) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant A1. It encodes isoform B1, which lacks an internal segment and is shorter, compared to isoform A1.
    Source sequence(s)
    AC122193, AC126692, BE851024, CA751341, CF733313, CN695929, CV557369
    Conserved Domains (2) summary
    cd00127
    Location:158272
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
  2. NM_130447.3NP_569714.2  dual specificity phosphatase 16 isoform A1

    See proteins identical to NP_569714.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A1) represents the longer transcript and encodes the longer isoform (A1).
    Source sequence(s)
    AC122193, AC126692, BC057321
    Consensus CDS
    CCDS39679.1
    UniProtKB/TrEMBL
    Q6PCP3
    Related
    ENSMUSP00000098419, OTTMUSP00000027061, ENSMUST00000100857, OTTMUST00000056331
    Conserved Domains (2) summary
    cd00127
    Location:158295
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000072.6 

    Range
    134715468..134792628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506587.1XP_006506650.1  

    See proteins identical to XP_006506650.1

    UniProtKB/TrEMBL
    Q6PCP3
    Conserved Domains (2) summary
    cd00127
    Location:158295
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
  2. XM_006506586.1XP_006506649.1  

    See proteins identical to XP_006506649.1

    UniProtKB/TrEMBL
    Q6PCP3
    Conserved Domains (2) summary
    cd00127
    Location:158295
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:10136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
  3. XM_006506588.1XP_006506651.1  

    Conserved Domains (1) summary
    cd00127
    Location:38175
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

Alternate Mm_Celera

Genomic

  1. AC_000028.1 

    Range
    137667703..137745584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181320.2: Suppressed sequence

    Description
    NM_181320.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.