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    Pink1 PTEN induced putative kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 68943, updated on 24-Jun-2016
    Official Symbol
    Pink1provided by MGI
    Official Full Name
    PTEN induced putative kinase 1provided by MGI
    Primary source
    MGI:MGI:1916193
    See related
    Ensembl:ENSMUSG00000028756 Vega:OTTMUSG00000009975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BRPK; AU042772; AW557854; mFLJ00387; 1190006F07Rik
    Orthologs
    Location:
    4; 4 D3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (138313409..138326296, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (137869324..137882211, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene kinesin family member 17 Neighboring gene dolichyl-di-phosphooligosaccharide-protein glycotransferase Neighboring gene microRNA 7019 Neighboring gene cytidine deaminase Neighboring gene family with sequence similarity 43, member B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    C3HC4-type RING finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    maintenance of protein location in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    mitophagy in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catecholamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cristae formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial electron transport, NADH to ubiquinone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of hydrogen peroxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    respiratory electron transport chain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitochondrial outer membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    serine/threonine-protein kinase PINK1, mitochondrial
    Names
    PTEN-induced putative kinase protein 1
    NP_081156.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026880.2NP_081156.2  serine/threonine-protein kinase PINK1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_081156.2

      Status: VALIDATED

      Source sequence(s)
      BC067066, CX238874
      Consensus CDS
      CCDS18825.1
      UniProtKB/Swiss-Prot
      Q99MQ3
      Related
      ENSMUSP00000030536, OTTMUSP00000010580, ENSMUST00000030536, OTTMUST00000023184
      Conserved Domains (1) summary
      cd14018
      Location:162511
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      138313409..138326296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)