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    Lrrk2 leucine-rich repeat kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 66725, updated on 23-Aug-2016
    Official Symbol
    Lrrk2provided by MGI
    Official Full Name
    leucine-rich repeat kinase 2provided by MGI
    Primary source
    MGI:MGI:1913975
    See related
    Ensembl:ENSMUSG00000036273 Vega:OTTMUSG00000020864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm927; cI-46; AW561911; 4921513O20Rik; 9330188B09Rik; D630001M17Rik
    Orthologs
    Location:
    15; 15 F1
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (91672809..91816124)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (91503655..91646555)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 13 Neighboring gene olfactomedin-like 2A pseudogene Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene RAS related protein 1b pseudogene Neighboring gene mucin 19 Neighboring gene submandibular gland protein C

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP-dependent protein kinase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    GTP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    MAP kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Rho GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Rho GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin destruction complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    glycoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    peroxidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IC
    Inferred by Curator
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase A binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor signaling complex scaffold activity IC
    Inferred by Curator
    more info
    PubMed 
    syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signalosome assembly IC
    Inferred by Curator
    more info
    PubMed 
    Wnt signalosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to dopamine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to manganese ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exploration behavior ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lysosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion localization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hydrogen peroxide-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    olfactory bulb development ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of canonical Wnt signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulation of dendritic spine morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of kidney size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of locomotion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lysosomal lumen pH ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron maturation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein kinase A signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle recycling TAS
    Traceable Author Statement
    more info
    PubMed 
    tangential migration from the subventricular zone to the olfactory bulb ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    amphisome ISO
    Inferred from Sequence Orthology
    more info
     
    autolysosome ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    multivesicular body, internal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton IC
    Inferred by Curator
    more info
    PubMed 
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    leucine-rich repeat serine/threonine-protein kinase 2
    NP_080006.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025730.3NP_080006.3  leucine-rich repeat serine/threonine-protein kinase 2

      See identical proteins and their annotated locations for NP_080006.3

      Status: VALIDATED

      Source sequence(s)
      AC099704, AC158752, AK014886, AK014938, AK034413, AK050702, AK052591, BF660966
      Consensus CDS
      CCDS37180.1
      UniProtKB/Swiss-Prot
      Q5S006
      UniProtKB/TrEMBL
      Q9CQG8
      Related
      ENSMUSP00000052584, OTTMUSP00000022827, ENSMUST00000060642, OTTMUST00000049323
      Conserved Domains (6) summary
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      COG1100
      Location:13331551
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cd00116
      Location:9861240
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam00069
      Location:18852129
      Pkinase; Protein kinase domain
      cd14068
      Location:18842135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      91672809..91816124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521277.3XP_006521340.1  

      Conserved Domains (6) summary
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      COG1100
      Location:13331551
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cd00116
      Location:9861240
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam13855
      Location:11731232
      LRR_8; Leucine rich repeat
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]
      cl21453
      Location:18842036
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001781561.1 RNA Sequence

    2. XR_875310.2 RNA Sequence