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    Trim59 tripartite motif-containing 59 [ Mus musculus (house mouse) ]

    Gene ID: 66949, updated on 3-Sep-2016
    Official Symbol
    Trim59provided by MGI
    Official Full Name
    tripartite motif-containing 59provided by MGI
    Primary source
    MGI:MGI:1914199
    See related
    Ensembl:ENSMUSG00000034317 Vega:OTTMUSG00000024493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrf1; TSBF1; 2310035M22Rik; 2700022F13Rik
    Orthologs
    Location:
    3; 3 E2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (69035292..69046400, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (68839216..68848664, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene microRNA 16-2 Neighboring gene structural maintenance of chromosomes 4 Neighboring gene microRNA 15b Neighboring gene uncharacterized LOC105244467 Neighboring gene karyopherin (importin) alpha 4

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tripartite motif-containing protein 59
    Names
    RING finger 1
    RING finger protein 1
    tumor suppressor TSBF1 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025863.3NP_080139.3  tripartite motif-containing protein 59

      See identical proteins and their annotated locations for NP_080139.3

      Status: VALIDATED

      Source sequence(s)
      AK009637, AK012269, AK016642, BE847098, CD541510
      Consensus CDS
      CCDS17402.1
      UniProtKB/Swiss-Prot
      Q922Y2
      Related
      ENSMUSP00000103432, OTTMUSP00000029298, ENSMUST00000107802, OTTMUST00000060095
      Conserved Domains (2) summary
      cd00162
      Location:963
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:92134
      zf-B_box; B-box zinc finger

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      69035292..69046400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501917.3XP_006501980.1  

      See identical proteins and their annotated locations for XP_006501980.1

      UniProtKB/Swiss-Prot
      Q922Y2
      Related
      ENSMUSP00000120270, OTTMUSP00000029299, ENSMUST00000136512, OTTMUST00000060096
      Conserved Domains (2) summary
      cd00162
      Location:963
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:92134
      zf-B_box; B-box zinc finger
    2. XM_011240200.1XP_011238502.1  

      See identical proteins and their annotated locations for XP_011238502.1

      UniProtKB/Swiss-Prot
      Q922Y2
      Conserved Domains (2) summary
      cd00162
      Location:963
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:92134
      zf-B_box; B-box zinc finger
    3. XM_011240201.2XP_011238503.1  

      See identical proteins and their annotated locations for XP_011238503.1

      UniProtKB/Swiss-Prot
      Q922Y2
      Conserved Domains (2) summary
      cd00162
      Location:963
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:92134
      zf-B_box; B-box zinc finger
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