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    Begain brain-enriched guanylate kinase-associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79146, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Begainprovided by RGD
    Official Full Name
    brain-enriched guanylate kinase-associatedprovided by RGD
    Primary source
    RGD:708347
    See related
    Ensembl:ENSRNOG00000004650 AllianceGenome:RGD:708347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of postsynaptic neurotransmitter receptor activity. Predicted to act upstream of or within evoked excitatory postsynaptic potential. Located in several cellular components, including dendrite; neuronal cell body; and synapse. Is active in glutamatergic synapse and postsynapse. Orthologous to human BEGAIN (brain enriched guanylate kinase associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 32.4), Lung (RPKM 6.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (133708010..133744264, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (127943651..127979876, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (132936964..132972569, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tryptophanyl-tRNA synthetase 1 Neighboring gene WD repeat domain 25 Neighboring gene ribosomal protein S18, pseudogene 3 Neighboring gene uncharacterized LOC102555774 Neighboring gene uncharacterized LOC120103622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein. Yao I, et al. J Neurosci, 2002 Jul 1. PMID 12097487, Free PMC Article
    2. Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury. Katano T, et al. eNeuro, 2016 Sep-Oct. PMID 27785460, Free PMC Article
    3. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. Deguchi M, et al. J Biol Chem, 1998 Oct 9. PMID 9756850
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within evoked excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brain-enriched guanylate kinase-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111115.1 → NP_001104585.1  brain-enriched guanylate kinase-associated protein isoform 1

      See identical proteins and their annotated locations for NP_001104585.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate 5'-terminal coding exon, compared to variant 2, resulting in a shorter protein (isoform 1) that has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AF064868, AF064869, BP478305, CB801805
      UniProtKB/TrEMBL
      A0A0G2K0E5, A6KBJ0
      Related
      ENSRNOP00000049699.3, ENSRNOT00000041903.6
      Conserved Domains (1) summary
      cl12013
      Location:35 → 152
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_024163.2 → NP_077077.1  brain-enriched guanylate kinase-associated protein isoform 2

      See identical proteins and their annotated locations for NP_077077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AF064868, BP478305
      UniProtKB/Swiss-Prot
      O88881, O88882
      UniProtKB/TrEMBL
      A0A0G2K0E5, A6KBI9
      Related
      ENSRNOP00000071412.2, ENSRNOT00000082216.2
      Conserved Domains (1) summary
      cl12013
      Location:41 → 158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      133708010..133744264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262544.1 → XP_063118614.1  brain-enriched guanylate kinase-associated protein isoform X12

    2. XM_039112985.2 → XP_038968913.1  brain-enriched guanylate kinase-associated protein isoform X4

      UniProtKB/TrEMBL
      A0A0G2K0E5
      Conserved Domains (1) summary
      COG1196
      Location:21 → 143
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_039112981.2 → XP_038968909.1  brain-enriched guanylate kinase-associated protein isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0E5
      Conserved Domains (1) summary
      COG1196
      Location:54 → 172
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_017594386.3 → XP_017449875.2  brain-enriched guanylate kinase-associated protein isoform X7

      UniProtKB/TrEMBL
      A0A0G2K0E5
      Conserved Domains (2) summary
      COG1196
      Location:54 → 172
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:574 → 640
      Pilt; Protein incorporated later into Tight Junctions

    5. XM_063262545.1 → XP_063118615.1  brain-enriched guanylate kinase-associated protein isoform X1

    6. XM_039112988.2 → XP_038968916.1  brain-enriched guanylate kinase-associated protein isoform X8

      UniProtKB/TrEMBL
      A0A0G2K0E5
      Conserved Domains (1) summary
      COG1196
      Location:2 → 124
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_039112987.2 → XP_038968915.1  brain-enriched guanylate kinase-associated protein isoform X6

      UniProtKB/TrEMBL
      A0A0G2K0E5
      Conserved Domains (1) summary
      COG1196
      Location:4 → 137
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_039112984.2 → XP_038968912.2  brain-enriched guanylate kinase-associated protein isoform X3

    9. XM_063262542.1 → XP_063118612.1  brain-enriched guanylate kinase-associated protein isoform X10

    10. XM_039112986.2 → XP_038968914.1  brain-enriched guanylate kinase-associated protein isoform X5

      UniProtKB/TrEMBL
      A0A0G2K0E5
      Conserved Domains (1) summary
      COG1196
      Location:19 → 141
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. XM_063262543.1 → XP_063118613.1  brain-enriched guanylate kinase-associated protein isoform X11

    12. XM_063262540.1 → XP_063118610.1  brain-enriched guanylate kinase-associated protein isoform X8

    13. XM_063262539.1 → XP_063118609.1  brain-enriched guanylate kinase-associated protein isoform X1

    14. XM_063262541.1 → XP_063118611.1  brain-enriched guanylate kinase-associated protein isoform X9

    15. XM_039112990.2 → XP_038968918.1  brain-enriched guanylate kinase-associated protein isoform X1

      UniProtKB/TrEMBL
      A6KBJ1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88881.1 GenPept UniProtKB/Swiss-Prot:O88881

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