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    Phox2b paired-like homeobox 2b [ Mus musculus (house mouse) ]

    Gene ID: 18935, updated on 30-Jun-2015
    Official Symbol
    Phox2bprovided by MGI
    Official Full Name
    paired-like homeobox 2bprovided by MGI
    Primary source
    MGI:MGI:1100882
    See related
    Ensembl:ENSMUSG00000012520; Vega:OTTMUSG00000037720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dilp1; Pmx2b; NBPhox
    Orthologs
    See Phox2b in Epigenomics, MapViewer
    Location:
    5 C3.1; 5 35.95 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (67094397..67099126, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (67485636..67490365, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene LIM and calponin homology domains 1 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene predicted gene, 33040 Neighboring gene predicted gene, 33167 Neighboring gene predicted gene, 33293 Neighboring gene predicted gene, 40314

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    autonomic nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation in hindbrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to BMP stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    efferent axon development in a lateral line nerve IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enteric nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hindbrain tangential cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neural crest cell migration involved in autonomic nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    noradrenergic neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    noradrenergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    parasympathetic nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of respiratory gaseous exchange by neurological system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrotrapezoid nucleus neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    paired mesoderm homeobox protein 2B
    Names
    GENA 269
    PHOX2B homeodomain protein
    dilated pupils 1
    neuroblastoma Phox
    paired mesoderm homeobox 2b

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008888.3NP_032914.1  paired mesoderm homeobox protein 2B

      See identical proteins and their annotated locations for NP_032914.1

      Status: VALIDATED

      Source sequence(s)
      BC079610
      Consensus CDS
      CCDS19316.1
      UniProtKB/Swiss-Prot
      O35690
      Related
      ENSMUSP00000012664, OTTMUSP00000054637, ENSMUST00000012664, OTTMUST00000097414
      Conserved Domains (1) summary
      cd00086
      Location:99157
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      67094397..67099126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      64399184..64403936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)