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CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 [ Homo sapiens (human) ]

Gene ID: 1545, updated on 21-Jul-2014
Official Symbol
CYP1B1provided by HGNC
Official Full Name
cytochrome P450, family 1, subfamily B, polypeptide 1provided by HGNC
Primary source
HGNC:2597
See related
Ensembl:ENSG00000138061; HPRD:03464; MIM:601771; Vega:OTTHUMG00000100970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP1B; GLC3A; CYPIB1; P4501B1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
See CYP1B1 in Epigenomics, MapViewer
Location:
2p22.2
Exon count :
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (38067603..38076181, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38294746..38303323, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 211 Neighboring gene regulator of microtubule dynamics 2 Neighboring gene RMDN2 antisense RNA 1 Neighboring gene zinc finger protein 430 pseudogene Neighboring gene CYP1B1 antisense RNA 1 Neighboring gene uncharacterized LOC102723739

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IDA
Inferred from Direct Assay
more info
 
heme binding TAS
Traceable Author Statement
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
oxygen binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular aromatic compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 
collagen fibril organization ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
epoxygenase P450 pathway TAS
Traceable Author Statement
more info
 
estrogen metabolic process IDA
Inferred from Direct Assay
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of JAK-STAT cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression involved in extracellular matrix organization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
retinal blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
steroid metabolic process IDA
Inferred from Direct Assay
more info
 
sterol metabolic process TAS
Traceable Author Statement
more info
 
toxin metabolic process IEA
Inferred from Electronic Annotation
more info
 
trabecular meshwork development ISS
Inferred from Sequence or Structural Similarity
more info
 
visual perception TAS
Traceable Author Statement
more info
PubMed 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
cytochrome P450 1B1
Names
cytochrome P450 1B1
microsomal monooxygenase
xenobiotic monooxygenase
aryl hydrocarbon hydroxylase
flavoprotein-linked monooxygenase
cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)
NP_000095.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008386.1 

    Range
    5001..13579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000104.3NP_000095.2  cytochrome P450 1B1

    See proteins identical to NP_000095.2

    Status: REVIEWED

    Source sequence(s)
    AK312686, BC012049, BP326939, BT019979, DA662236, U03688
    Consensus CDS
    CCDS1793.1
    UniProtKB/Swiss-Prot
    Q16678
    UniProtKB/TrEMBL
    Q53TK1
    Related
    ENSP00000260630, OTTHUMP00000126963, ENST00000260630, OTTHUMT00000218580
    Conserved Domains (1) summary
    pfam00067
    Location:51520
    Blast Score: 873
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    38067603..38076181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    38034680..38043258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    38224106..38232684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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