Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CYP1B1 cytochrome P450 family 1 subfamily B member 1 [ Homo sapiens (human) ]

    Gene ID: 1545, updated on 14-Jun-2016
    Official Symbol
    CYP1B1provided by HGNC
    Official Full Name
    cytochrome P450 family 1 subfamily B member 1provided by HGNC
    Primary source
    HGNC:HGNC:2597
    See related
    Ensembl:ENSG00000138061 HPRD:03464; MIM:601771; Vega:OTTHUMG00000100970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CP1B; GLC3A; CYPIB1; P4501B1
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2p22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (38067603..38076181, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38294746..38303323, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene regulator of microtubule dynamics 2 Neighboring gene RMDN2 antisense RNA 1 Neighboring gene zinc finger protein 430 pseudogene Neighboring gene uncharacterized LOC107985872 Neighboring gene uncharacterized LOC105374466 Neighboring gene CYP1B1 antisense RNA 1 Neighboring gene uncharacterized LOC107985871 Neighboring gene RNA, U6 small nuclear 951, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ51599, FLJ51600

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    arachidonic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular aromatic compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen fibril organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endothelial cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    epoxygenase P450 pathway TAS
    Traceable Author Statement
    more info
     
    estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    omega-hydroxylase P450 pathway TAS
    Traceable Author Statement
    more info
     
    oxidation-reduction process TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    retinal blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sterol metabolic process TAS
    Traceable Author Statement
    more info
     
    toxin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    trabecular meshwork development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    visual perception TAS
    Traceable Author Statement
    more info
    PubMed 
    xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    cytochrome P450 1B1
    Names
    aryl hydrocarbon hydroxylase
    cytochrome P450, family 1, subfamily B, polypeptide 1
    cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)
    flavoprotein-linked monooxygenase
    microsomal monooxygenase
    xenobiotic monooxygenase
    NP_000095.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008386.2 RefSeqGene

      Range
      4921..13499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000104.3NP_000095.2  cytochrome P450 1B1

      See identical proteins and their annotated locations for NP_000095.2

      Status: REVIEWED

      Source sequence(s)
      AK312686, BC012049, BP326939, BT019979, DA662236, U03688
      Consensus CDS
      CCDS1793.1
      UniProtKB/Swiss-Prot
      Q16678
      UniProtKB/TrEMBL
      Q53TK1
      Related
      ENSP00000478561, OTTHUMP00000275829, ENST00000610745, OTTHUMT00000218580
      Conserved Domains (1) summary
      pfam00067
      Location:51520
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      38067603..38076181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      38224106..38232684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)