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Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24296, updated on 16-Oct-2014
Official Symbol
Cyp1a1provided by RGD
Official Full Name
cytochrome P450, family 1, subfamily a, polypeptide 1provided by RGD
Primary source
RGD:2458
See related
Ensembl:ENSRNOG00000019500
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
AHH; AHRR; CP11; CYP1; Cyp45c; P1-450; P450-C; P450DX; Cypc45c; P-450MC
Summary
monooxygenase that plays a role in dioxin metabolism and detoxification which is 3-methylcholanthrene-inducible [RGD, Feb 2006]
See Cyp1a1 in MapViewer
Location:
8q24
Exon count:
7
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62472087..62478122)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (62249046..62255081)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene c-src tyrosine kinase Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 2 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene CDC-like kinase 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
demethylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
flavonoid 3'-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
Contributes_to oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity, acting on diphenols and related substances as donors IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
steroid hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D 24-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
vitamin D 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
9-cis-retinoic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
 
amine metabolic process IEA
Inferred from Electronic Annotation
more info
 
amine metabolic process ISO
Inferred from Sequence Orthology
more info
 
camera-type eye development IEP
Inferred from Expression Pattern
more info
PubMed 
cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
coumarin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
demethylation IDA
Inferred from Direct Assay
more info
PubMed 
developmental process IEP
Inferred from Expression Pattern
more info
PubMed 
dibenzo-p-dioxin catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
dibenzo-p-dioxin catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
dibenzo-p-dioxin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT dibenzo-p-dioxin metabolic process ISO
Inferred from Sequence Orthology
more info
 
digestive tract development IEP
Inferred from Expression Pattern
more info
PubMed 
drug metabolic process IEA
Inferred from Electronic Annotation
more info
 
drug metabolic process ISO
Inferred from Sequence Orthology
more info
 
embryo development ending in birth or egg hatching IEP
Inferred from Expression Pattern
more info
PubMed 
flavonoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hepatocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
heterocycle metabolic process ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
insecticide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
liver development IEP
Inferred from Expression Pattern
more info
PubMed 
maternal process involved in parturition IEP
Inferred from Expression Pattern
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
porphyrin-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to food IEP
Inferred from Expression Pattern
more info
PubMed 
response to herbicide IEP
Inferred from Expression Pattern
more info
PubMed 
response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to iron(III) ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to nematode IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
toxin metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cytochrome P450 1A1
Names
cytochrome P450 1A1
CYPIA1
P450MT2
P450form6
dioxin-inducible
cytochrome P1-450
cytochrome P450-C
cytochrome P450MT2
cytochrome P450, 1a1
microsomal monooxygenase
xenobiotic monooxygenase
aryl hydrocarbon hydroxylase
flavoprotein-linked monooxygenase
cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c)
cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c)
NP_036672.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012540.2NP_036672.2  cytochrome P450 1A1

    See proteins identical to NP_036672.2

    Status: PROVISIONAL

    Source sequence(s)
    X00469
    UniProtKB/Swiss-Prot
    P00185
    Related
    ENSRNOP00000026473, ENSRNOT00000026473
    Conserved Domains (1) summary
    pfam00067
    Location:44496
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 

    Range
    62472087..62478122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243150.2XP_006243212.1  

    See proteins identical to XP_006243212.1

    UniProtKB/Swiss-Prot
    P00185
    Conserved Domains (1) summary
    pfam00067
    Location:44496
    p450; Cytochrome P450

Alternate Rn_Celera

Genomic

  1. AC_000076.1 

    Range
    57561801..57567827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)