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    POC4 Poc4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855959, updated on 4-Feb-2024

    Summary

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    Gene symbol
    POC4
    Gene description
    Poc4p
    Primary source
    SGD:S000006065
    Locus tag
    YPL144W
    See related
    AllianceGenome:SGD:S000006065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DMP1; PBA4
    Summary
    Involved in chaperone-mediated protein complex assembly and proteasome assembly. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (280480..280926)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Nop53p Neighboring gene oxysterol-binding protein KES1 Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L33A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteasome subunit α1 overexpression preferentially drives canonical proteasome biogenesis and enhances stress tolerance in yeast. Howell LA, et al. Sci Rep, 2019 Aug 27. PMID 31455793, Free PMC Article
    2. Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation. Takagi K, et al. Biochem Biophys Res Commun, 2014 Jul 25. PMID 24996173
    3. Blm10 binds to pre-activated proteasome core particles with open gate conformation. Lehmann A, et al. EMBO Rep, 2008 Dec. PMID 18927584, Free PMC Article
    4. N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function. Yashiroda H, et al. Mol Cell Biol, 2015 Jan. PMID 25332237, Free PMC Article
    5. A multimeric assembly factor controls the formation of alternative 20S proteasomes. Kusmierczyk AR, et al. Nat Struct Mol Biol, 2008 Mar. PMID 18278055

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chaperone-mediated protein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaperone-mediated protein complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in proteasome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Poc4p
    NP_015181.1
    • Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      280480..280926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183958.1 → NP_015181.1  TPA: Poc4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015181.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3M5, Q12245, Q6Q5F7
      UniProtKB/TrEMBL
      A0A6A5Q0V7, A6ZWB0, B3LKT4, C7GJ95, G2WP39, N1NVV0
      Conserved Domains (1) summary
      pfam10448
      Location:1 → 143
      POC3_POC4; 20S proteasome chaperone assembly proteins 3 and 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12245.1

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