HIPK2 homeodomain interacting protein kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HIPK2provided by HGNC
Official Full Name: homeodomain interacting protein kinase 2provided by HGNC
Primary source: HGNC:HGNC:14402
See related: Ensembl:ENSG00000064393 MIM:606868; AllianceGenome:HGNC:14402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRO0593
Summary: This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression: Ubiquitous expression in brain (RPKM 22.7), kidney (RPKM 17.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q34

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (139561570..139777998, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (140874868..141091290, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (139246316..139477797, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ_0008410 contributes to fibroblast-like synoviocytes dysfunction by regulating miR-149-5p/HIPK2 axis.
Title: Circ_0008410 contributes to fibroblast-like synoviocytes dysfunction by regulating miR-149-5p/HIPK2 axis.
MicroRNA-483-3p Inhibitor Ameliorates Sepsis-Induced Intestinal Injury by Attenuating Cell Apoptosis and Cytotoxicity Via Regulating HIPK2.
Title: MicroRNA-483-3p Inhibitor Ameliorates Sepsis-Induced Intestinal Injury by Attenuating Cell Apoptosis and Cytotoxicity Via Regulating HIPK2.
Plasma circRNA HIPK2 as a putative biomarker for the diagnosis and prediction of therapeutic effects in major depressive disorder.
Title: Plasma circRNA HIPK2 as a putative biomarker for the diagnosis and prediction of therapeutic effects in major depressive disorder.
miR-147b is an oncomiR acting synergistically with HIPK2 to promote pancreatic carcinogenesis.
Title: miR-147b is an oncomiR acting synergistically with HIPK2 to promote pancreatic carcinogenesis.
Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2.
Title: Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2.
Determination of homeodomain interacting protein kinase 2 polymorphisms rs2058265, rs6464214, and rs7456421 in patients with kidney stone.
Title: Determination of homeodomain interacting protein kinase 2 polymorphisms rs2058265, rs6464214, and rs7456421 in patients with kidney stone.
HIPK2 in the physiology of nervous system and its implications in neurological disorders.
Title: HIPK2 in the physiology of nervous system and its implications in neurological disorders.
LncRNA PSCK6-AS1-HIPK2 promotes Th1 differentiation via STAT1 phosphorylation to regulate colitis-related mucosal barrier damage.
Title: LncRNA PSCK6-AS1-HIPK2 promotes Th1 differentiation via STAT1 phosphorylation to regulate colitis-related mucosal barrier damage.
HIPK2 in cancer biology and therapy: Recent findings and future perspectives.
Title: HIPK2 in cancer biology and therapy: Recent findings and future perspectives.
Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling.
Title: Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling.

Submit: New GeneRIF Correction See all GeneRIFs (151)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH79233 (e-PCR)
- UniSTS:51207

GDB:4585507 (e-PCR)
- UniSTS:57622

D7S2129E (e-PCR)
- UniSTS:58668

RH11956 (e-PCR)
- UniSTS:51507

SHGC-36801 (e-PCR)
- UniSTS:20046

D7S2142E (e-PCR)
- UniSTS:11862

D7S2728 (e-PCR)
- UniSTS:15964

RH93472 (e-PCR)
- UniSTS:85854

SHGC-37120 (e-PCR)
- UniSTS:72041

GDB:4585291 (e-PCR)
- UniSTS:34446

D7S2098E (e-PCR)
- UniSTS:59799

SHGC-5597 (e-PCR)
- UniSTS:50335

RH12870 (e-PCR)
- UniSTS:58018

A006W25 (e-PCR)
- UniSTS:27555

RH69335 (e-PCR)
- UniSTS:76465

D4S3203 (e-PCR)
- UniSTS:65461

GDB:4585152 (e-PCR)
- UniSTS:66236

GDB:4585382 (e-PCR)
- UniSTS:209

RH75568 (e-PCR)
- UniSTS:89051

GDB:4585413 (e-PCR)
- UniSTS:76007

G20366 (e-PCR)
- UniSTS:38122

D7S1876E (e-PCR)
- UniSTS:473323

A005N45 (e-PCR)
- UniSTS:38123

HSC188_(GAP_109_G) (e-PCR)
- UniSTS:255213

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables virion binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in PML body organization	TAS Traceable Author Statement more info	PubMed
involved_in SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in adult walking behavior	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	TAS Traceable Author Statement more info	PubMed
involved_in embryonic camera-type eye morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic retina morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	TAS Traceable Author Statement more info
involved_in erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in eye development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	TAS Traceable Author Statement more info	PubMed
involved_in iris morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in lens induction in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein binding	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info
involved_in respiratory system process	IEA Inferred from Electronic Annotation more info
involved_in retina layer formation	IEA Inferred from Electronic Annotation more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in voluntary musculoskeletal movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with PML body	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with PML body	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeodomain-interacting protein kinase 2

Names: hHIPk2

NP_001106710.1

EC 2.7.11.1

NP_073577.3

EC 2.7.11.1

XP_011514379.1

EC 2.7.11.1

XP_011514380.1

EC 2.7.11.1

XP_011514381.1

EC 2.7.11.1

XP_011514382.1

EC 2.7.11.1

XP_011514383.1

EC 2.7.11.1

XP_047276216.1

EC 2.7.11.1

XP_047276217.1

EC 2.7.11.1

XP_047276218.1

EC 2.7.11.1

XP_047276219.1

EC 2.7.11.1

XP_047276220.1

EC 2.7.11.1

XP_047276221.1

EC 2.7.11.1

XP_054213962.1

EC 2.7.11.1

XP_054213963.1

EC 2.7.11.1

XP_054213964.1

EC 2.7.11.1

XP_054213965.1

EC 2.7.11.1

XP_054213966.1

EC 2.7.11.1

XP_054213967.1

EC 2.7.11.1

XP_054213968.1

EC 2.7.11.1

XP_054213969.1

EC 2.7.11.1

XP_054213970.1

EC 2.7.11.1

XP_054213971.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113239.3 → NP_001106710.1 homeodomain-interacting protein kinase 2 isoform 2

See identical proteins and their annotated locations for NP_001106710.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter, as compared to isoform 1.

Source sequence(s)

AC005531, AC006021, AF208291, AF326592, AI580907, CK818532

Consensus CDS

CCDS75666.1

UniProtKB/Swiss-Prot

Q9H2X6

Related

ENSP00000413724.2, ENST00000428878.6

Conserved Domains (2) summary

smart00220
Location:199 → 527

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:183 → 537

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
NM_022740.5 → NP_073577.3 homeodomain-interacting protein kinase 2 isoform 1

See identical proteins and their annotated locations for NP_073577.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the full-length isoform (1).

Source sequence(s)

AC005531, AC006021, AF208291, AF326592, AI580907, CK818532

Consensus CDS

CCDS75667.1

UniProtKB/Swiss-Prot

Q75MR7, Q8WWI4, Q9H2X6, Q9H2Y1

Related

ENSP00000385571.3, ENST00000406875.8

Conserved Domains (2) summary

smart00220
Location:199 → 527

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:183 → 537

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

139561570..139777998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047420265.1 → XP_047276221.1 homeodomain-interacting protein kinase 2 isoform X8
XM_047420260.1 → XP_047276216.1 homeodomain-interacting protein kinase 2 isoform X6
XM_047420264.1 → XP_047276220.1 homeodomain-interacting protein kinase 2 isoform X7
XM_047420261.1 → XP_047276217.1 homeodomain-interacting protein kinase 2 isoform X7
XM_047420262.1 → XP_047276218.1 homeodomain-interacting protein kinase 2 isoform X7
XM_047420263.1 → XP_047276219.1 homeodomain-interacting protein kinase 2 isoform X7
XM_011516080.4 → XP_011514382.1 homeodomain-interacting protein kinase 2 isoform X4

Conserved Domains (2) summary

smart00220
Location:378 → 706

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:362 → 716

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
XM_011516079.4 → XP_011514381.1 homeodomain-interacting protein kinase 2 isoform X3

Conserved Domains (2) summary

smart00220
Location:378 → 706

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:362 → 716

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
XM_011516078.4 → XP_011514380.1 homeodomain-interacting protein kinase 2 isoform X2

Conserved Domains (2) summary

smart00220
Location:378 → 706

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:362 → 716

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
XM_011516077.4 → XP_011514379.1 homeodomain-interacting protein kinase 2 isoform X1

Conserved Domains (2) summary

smart00220
Location:378 → 706

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:362 → 716

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
XM_011516081.3 → XP_011514383.1 homeodomain-interacting protein kinase 2 isoform X5

Conserved Domains (2) summary

smart00220
Location:207 → 535

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:191 → 545

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

140874868..141091290 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054357996.1 → XP_054213971.1 homeodomain-interacting protein kinase 2 isoform X8
XM_054357992.1 → XP_054213967.1 homeodomain-interacting protein kinase 2 isoform X6
XM_054357995.1 → XP_054213970.1 homeodomain-interacting protein kinase 2 isoform X7
XM_054357993.1 → XP_054213968.1 homeodomain-interacting protein kinase 2 isoform X7
XM_054357994.1 → XP_054213969.1 homeodomain-interacting protein kinase 2 isoform X7
XM_054357990.1 → XP_054213965.1 homeodomain-interacting protein kinase 2 isoform X4
XM_054357989.1 → XP_054213964.1 homeodomain-interacting protein kinase 2 isoform X3
XM_054357988.1 → XP_054213963.1 homeodomain-interacting protein kinase 2 isoform X2
XM_054357987.1 → XP_054213962.1 homeodomain-interacting protein kinase 2 isoform X1
XM_054357991.1 → XP_054213966.1 homeodomain-interacting protein kinase 2 isoform X5