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    Eef2 eukaryotic translation elongation factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 13629, updated on 23-Mar-2024

    Summary

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    Official Symbol
    Eef2provided by MGI
    Official Full Name
    eukaryotic translation elongation factor 2provided by MGI
    Primary source
    MGI:MGI:95288
    See related
    Ensembl:ENSMUSG00000034994 AllianceGenome:MGI:95288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ef-2
    Summary
    Enables GTPase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and translational elongation. Located in cytoplasm. Part of polysome. Is active in synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 1248.0), colon adult (RPKM 810.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eef2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81012465..81018343)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81176631..81182509)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E463 Neighboring gene STARR-positive B cell enhancer ABC_E8349 Neighboring gene STARR-seq mESC enhancer starr_27318 Neighboring gene zinc finger and BTB domain containing 7a Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene STARR-positive B cell enhancer ABC_E901 Neighboring gene STARR-positive B cell enhancer ABC_E8866 Neighboring gene STARR-positive B cell enhancer ABC_E3901 Neighboring gene STARR-positive B cell enhancer ABC_E5157 Neighboring gene STARR-positive B cell enhancer ABC_E2329 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene death-associated protein kinase 3 Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene nicotinamide riboside kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior. Ma X, et al. EMBO Rep, 2022 Oct 6. PMID 35993189, Free PMC Article
    2. The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain. Yoon SH, et al. Mol Brain, 2021 Sep 15. PMID 34526091, Free PMC Article
    3. Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes. Gerashchenko MV, et al. Sci Rep, 2020 Sep 23. PMID 32968084, Free PMC Article
    4. Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase. Jung GA, et al. Exp Mol Med, 2011 Oct 31. PMID 21778808, Free PMC Article
    5. Identification of a 100-kDa phosphoprotein in developing murine embryos as elongation factor 2. Brown TL, et al. Arch Biochem Biophys, 1994 Feb 15. PMID 8117099

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells.
      Title: Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells.
    2. eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior.
      Title: eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior.
    3. Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2alpha and eEF2.
      Title: Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2.
    4. The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain.
      Title: The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain.
    5. Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.
      Title: Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.
    6. Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.
      Title: Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.
    7. PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
      Title: PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
    8. Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
      Title: Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
    9. Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis.
      Title: Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis.
    10. IL-6 induces the activation of the Stat3 signaling and promotes the downmodulation of the p90RSK/eEF2 and mTOR/p70S6K axes, while it does not affect the activation of AKT.
      Title: IL-6 impairs myogenic differentiation by downmodulation of p90RSK/eEF2 and mTOR/p70S6K axes, without affecting AKT activity.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC98463

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5S rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation at postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    elongation factor 2
    NP_031933.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007907.3 → NP_031933.1  elongation factor 2

      See identical proteins and their annotated locations for NP_031933.1

      Status: VALIDATED

      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS35993.1
      UniProtKB/Swiss-Prot
      P58252, Q544E4
      UniProtKB/TrEMBL
      Q3TJZ1, Q3TK17, Q3TX47, Q3UDC8
      Related
      ENSMUSP00000046101.10, ENSMUST00000047864.11
      Conserved Domains (6) summary
      cd01885
      Location:20 → 233
      EF2; Elongation Factor 2 (EF2) in archaea and eukarya
      cd01681
      Location:574 → 746
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:742 → 821
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      PTZ00416
      Location:1 → 858
      PTZ00416; elongation factor 2; Provisional
      cd03700
      Location:394 → 488
      EF2_snRNP_like_II; Domain II of elongation factor 2 and C-terminal domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein
      cd16261
      Location:503 → 574
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81012465..81018343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58252.2 GenPept UniProtKB/Swiss-Prot:P58252

    Gene LinkOut

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