Suz12 SUZ12 polycomb repressive complex 2 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Suz12provided by MGI
Official Full Name: SUZ12 polycomb repressive complex 2 subunitprovided by MGI
Primary source: MGI:MGI:1261758
See related: Ensembl:ENSMUSG00000017548 AllianceGenome:MGI:1261758
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0160; D11Ertd530e; 2610028O16Rik
Summary: This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Expression: Broad expression in liver E14 (RPKM 18.5), CNS E11.5 (RPKM 16.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 47.36 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (79883932..79924949)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (79993106..80034123)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs.
Title: SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs.
Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
Title: Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis.
Title: Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis.
INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes.
Title: INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes.
Here we show that CRISPR/Cas9-mediated inactivation of Suz12 cooperates with mutant JAK3 to drive T-cell transformation and T-cell acute lymphoblastic leukemia development
Title: Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia.
SUZ12 binds to CpG islands and this stable recruitment to genomic loci is essential for correct H3K27 methylation patterns.
Title: Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.
Nsd1 is a key modulator of PRC2 function required for regulating the demarcation of genome-wide H3K27me2 and H3K27me3 domains in embryonic stem cells.
Title: The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells.
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
Title: MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.
Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement.
Title: The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.
lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program.
Title: lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (7) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135952 (e-PCR)
- UniSTS:209948

AW536442 (e-PCR)
- UniSTS:180269

Suz12 (e-PCR), detects polymorphism
- UniSTS:498256

A007E42 (e-PCR)
- UniSTS:68707

NoName (e-PCR)
- UniSTS:236662

UniSTS:236667 (e-PCR)
- UniSTS:236667

AU016842 (e-PCR)
- UniSTS:160131

AU022339 (e-PCR)
- UniSTS:167061

D11Bhm110 (e-PCR), detects polymorphism
- UniSTS:141546

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in facultative heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within random inactivation of X chromosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	IDA Inferred from Direct Assay more info	PubMed
part_of ESC/E(Z) complex	ISO Inferred from Sequence Orthology more info
part_of RSC-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin silencing complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of sex chromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polycomb protein Suz12

Names: suppressor of zeste 12 homolog; suppressor of zeste 12 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163018.1 → NP_001156490.1 polycomb protein Suz12 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.

Source sequence(s)

AK076010, BC064461

Consensus CDS

CCDS48860.1

UniProtKB/TrEMBL

E9PW15

Related

ENSMUSP00000126932.2, ENSMUST00000163272.2

Conserved Domains (1) summary

pfam09733
Location:525 → 659

VEFS-Box; VEFS-Box of polycomb protein
NM_199196.2 → NP_954666.1 polycomb protein Suz12 isoform 1

See identical proteins and their annotated locations for NP_954666.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK076010, BC064461

Consensus CDS

CCDS25125.1

UniProtKB/Swiss-Prot

B1AQE5, Q80U70, Q80Y10, Q99L07

Related

ENSMUSP00000017692.9, ENSMUST00000017692.15

Conserved Domains (1) summary

pfam09733
Location:548 → 682

VEFS-Box; VEFS-Box of polycomb protein