Flt1 FMS-like tyrosine kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Flt1provided by MGI
Official Full Name: FMS-like tyrosine kinase 1provided by MGI
Primary source: MGI:MGI:95558
See related: Ensembl:ENSMUSG00000029648 AllianceGenome:MGI:95558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Flt-1; sFlt1; VEGFR1; VEGFR-1
Summary: Enables identical protein binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including blood vessel morphogenesis; embryonic morphogenesis; and hyaloid vascular plexus regression. Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 35.7), lung adult (RPKM 11.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 87.01 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (147498414..147663419, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (147561604..147726438, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
Title: SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
Knockdown of VEGFB/VEGFR1 Signaling Promotes White Adipose Tissue Browning and Skeletal Muscle Development.
Title: Knockdown of VEGFB/VEGFR1 Signaling Promotes White Adipose Tissue Browning and Skeletal Muscle Development.
Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1.
Title: Reducing VEGFB expression regulates the balance of glucose and lipid metabolism in mice via VEGFR1.
Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis.
Title: Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis.
VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway.
Title: VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway.
Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model.
Title: Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model.
AgeR deletion decreases soluble fms-like tyrosine kinase 1 production and improves post-ischemic angiogenesis in uremic mice.
Title: AgeR deletion decreases soluble fms-like tyrosine kinase 1 production and improves post-ischemic angiogenesis in uremic mice.
The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death.
Title: The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death.
VEGFR1-Targeted Contrast-Enhanced Ultrasound Imaging Quantification of Vasculogenic Mimicry Microcirculation in a Mouse Model of Choroidal Melanoma.
Title: VEGFR1-Targeted Contrast-Enhanced Ultrasound Imaging Quantification of Vasculogenic Mimicry Microcirculation in a Mouse Model of Choroidal Melanoma.
Absence of VEGFR-1/Flt-1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model.
Title: Absence of VEGFR-1/Flt-1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (159)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Flt1 (e-PCR), detects polymorphism
- UniSTS:143118

Flt1 (e-PCR), detects polymorphism
- UniSTS:143119

Flt1 (e-PCR), detects polymorphism
- UniSTS:143120

Flt1 (e-PCR), detects polymorphism
- UniSTS:498723

Flt1 (e-PCR), detects polymorphism
- UniSTS:498470

AI323757 (e-PCR)
- UniSTS:185649

Flt1 (e-PCR), detects polymorphism
- UniSTS:463942

Flt1 (e-PCR), detects polymorphism
- UniSTS:280402

Flt1 (e-PCR), detects polymorphism
- UniSTS:499133

D5Dcr8 (e-PCR), detects polymorphism
- UniSTS:479725

D8Mit181 (e-PCR)
- UniSTS:159474

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables vascular endothelial growth factor receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaloid vascular plexus regression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: vascular endothelial growth factor receptor 1

Names: embryonic receptor kinase 2; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor

NP_001350064.1

EC 2.7.10.1

NP_034358.2

EC 2.7.10.1

XP_006504864.1

EC 2.7.10.1

XP_006504865.1

EC 2.7.10.1

XP_006504866.1

EC 2.7.10.1

XP_011239302.1

EC 2.7.10.1

XP_036020680.1

EC 2.7.10.1

XP_036020681.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363135.1 → NP_001350064.1 vascular endothelial growth factor receptor 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC131730, AK013236, AK167497, BP763953

Consensus CDS

CCDS90022.1

UniProtKB/TrEMBL

O55095, Q3TJC1, Q8K1H4

Related

ENSMUSP00000106158.2, ENSMUST00000110529.6

Conserved Domains (4) summary

smart00408
Location:570 → 641

IGc2; Immunoglobulin C-2 Type

smart00409
Location:144 → 220

IG; Immunoglobulin

pfam13927
Location:428 → 540

Ig_3; Immunoglobulin domain

cl11960
Location:354 → 425

Ig; Immunoglobulin domain
NM_010228.4 → NP_034358.2 vascular endothelial growth factor receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_034358.2

Status: VALIDATED

Source sequence(s)

AC122299, AC131730

Consensus CDS

CCDS19879.1

UniProtKB/Swiss-Prot

O55094, P35969, Q61517

UniProtKB/TrEMBL

A0A0R4J0A4

Related

ENSMUSP00000031653.6, ENSMUST00000031653.12

Conserved Domains (8) summary

cd00096
Location:452 → 550

Ig; Immunoglobulin domain

smart00408
Location:677 → 739

IGc2; Immunoglobulin C-2 Type

smart00409
Location:570 → 641

IG; Immunoglobulin

smart00410
Location:238 → 329

IG_like; Immunoglobulin like

pfam07679
Location:662 → 749

I-set; Immunoglobulin I-set domain

pfam07714
Location:828 → 1154

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:354 → 425

Ig; Immunoglobulin domain

cl21453
Location:820 → 1157

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

147498414..147663419 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164787.1 → XP_036020680.1 vascular endothelial growth factor receptor 1 isoform X2

Conserved Domains (4) summary

smart00408
Location:4 → 75

IGc2; Immunoglobulin C-2 Type

pfam07679
Location:96 → 183

I-set; Immunoglobulin I-set domain

cd00096
Location:114 → 117

Ig; Ig strand B [structural motif]

cl21453
Location:254 → 591

PKc_like; Protein Kinases, catalytic domain
XM_011241000.4 → XP_011239302.1 vascular endothelial growth factor receptor 1 isoform X3

UniProtKB/TrEMBL

Q3TJC1, Q8K1H4

Conserved Domains (5) summary

smart00408
Location:570 → 641

IGc2; Immunoglobulin C-2 Type

smart00410
Location:144 → 220

IG_like; Immunoglobulin like

pfam07679
Location:662 → 749

I-set; Immunoglobulin I-set domain

pfam13927
Location:429 → 540

Ig_3; Immunoglobulin domain

cl11960
Location:354 → 425

Ig; Immunoglobulin domain
XM_006504801.5 → XP_006504864.1 vascular endothelial growth factor receptor 1 isoform X1

Conserved Domains (4) summary

smart00408
Location:570 → 641

IGc2; Immunoglobulin C-2 Type

smart00409
Location:144 → 220

IG; Immunoglobulin

pfam13927
Location:429 → 540

Ig_3; Immunoglobulin domain

cl11960
Location:354 → 425

Ig; Immunoglobulin domain
XM_006504802.5 → XP_006504865.1 vascular endothelial growth factor receptor 1 isoform X4

UniProtKB/TrEMBL

Q3TJC1, Q8K1H4

Conserved Domains (4) summary

smart00408
Location:570 → 641

IGc2; Immunoglobulin C-2 Type

smart00410
Location:144 → 220

IG_like; Immunoglobulin like

pfam13927
Location:429 → 540

Ig_3; Immunoglobulin domain

cl11960
Location:354 → 425

Ig; Immunoglobulin domain
XM_006504803.5 → XP_006504866.1 vascular endothelial growth factor receptor 1 isoform X5

UniProtKB/TrEMBL

Q3TJC1, Q8K1H4

Conserved Domains (4) summary

smart00408
Location:570 → 641

IGc2; Immunoglobulin C-2 Type

smart00409
Location:144 → 220

IG; Immunoglobulin

pfam13927
Location:429 → 540

Ig_3; Immunoglobulin domain

cl11960
Location:354 → 425

Ig; Immunoglobulin domain
XM_036164788.1 → XP_036020681.1 vascular endothelial growth factor receptor 1 isoform X6

UniProtKB/TrEMBL

Q9DAV2

Conserved Domains (4) summary

smart00410
Location:144 → 220

IG_like; Immunoglobulin like

pfam13927
Location:428 → 468

Ig_3; Immunoglobulin domain

cd00096
Location:334 → 338

Ig; Ig strand A [structural motif]

cl11960
Location:334 → 425

Ig; Immunoglobulin domain