ROBO1 roundabout guidance receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ROBO1provided by HGNC
Official Full Name: roundabout guidance receptor 1provided by HGNC
Primary source: HGNC:HGNC:10249
See related: Ensembl:ENSG00000169855 MIM:602430; AllianceGenome:HGNC:10249
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NORS; NYS8; SAX3; CPHD8; DUTT1
Summary: Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Expression: Ubiquitous expression in brain (RPKM 11.9), skin (RPKM 9.4) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p12.3

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (78597239..79767998, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (78652524..79823991, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (78646389..79817148, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy.
Title: Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy.
ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
Title: ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.
MicroRNA-588 regulates the invasive, migratory and vasculogenic mimicry-forming abilities of hypoxic glioma cells by targeting ROBO1.
Title: MicroRNA-588 regulates the invasive, migratory and vasculogenic mimicry-forming abilities of hypoxic glioma cells by targeting ROBO1.
Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2.
Title: Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2.
NMR analysis suggests the terminal domains of Robo1 remain extended but are rigidified in the presence of heparan sulfate.
Title: NMR analysis suggests the terminal domains of Robo1 remain extended but are rigidified in the presence of heparan sulfate.
Identification of non-synonymous variations in ROBO1 and GATA5 genes in a family with bicuspid aortic valve disease.
Title: Identification of non-synonymous variations in ROBO1 and GATA5 genes in a family with bicuspid aortic valve disease.
Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.
Title: Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.
MiR-218 Targeted Regulation of Robol Expression Regulates Proliferation, Invasion and Migration of Glioma Cells.
Title: MiR-218 Targeted Regulation of Robol Expression Regulates Proliferation, Invasion and Migration of Glioma Cells.
An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
Title: An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract.
Title: Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract.

Submit: New GeneRIF Correction See all GeneRIFs (119)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Neurooculorenal syndrome MedGen: C5830377 OMIM: 620305 GeneReviews: Not available	not available
Nystagmus, congenital, autosomal recessive MedGen: C3151571 OMIM: 257400 GeneReviews: Not available	not available
Pituitary hormone deficiency, combined or isolated, 8 MedGen: C5830375 OMIM: 620303 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2018-09-25) ClinGen Genome Curation Page Haploinsufficency No evidence available (Last evaluated 2018-09-25) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs). EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of liver enzymes in korean children. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced ROBO1-actin association	PubMed
	env	Inhibition of M-tropic HIV-1 gp120-induced transendothelial migration by SLIT2N involves SLIT2N-mediated enhancement of co-localization of Robo1 with WASp and LSP1 in immature monocyte-derived dendritic cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-77118 (e-PCR)
- UniSTS:4875

SHGC-148459 (e-PCR)
- UniSTS:176406

SHGC-81445 (e-PCR)
- UniSTS:103200

SHGC-77115 (e-PCR)
- UniSTS:76843

SHGC-110680 (e-PCR)
- UniSTS:167984

fi28b09.x1 (e-PCR)
- UniSTS:197176

RH120182 (e-PCR)
- UniSTS:133176

RH45408 (e-PCR)
- UniSTS:33342

D3S1274 (e-PCR), detects polymorphism
- UniSTS:77123

SHGC-154157 (e-PCR)
- UniSTS:177990

Robo1 (e-PCR), detects polymorphism
- UniSTS:498508

SHGC-35070 (e-PCR)
- UniSTS:76882

SHGC-84894 (e-PCR)
- UniSTS:104787

D3S2840E (e-PCR)
- UniSTS:150868

SHGC-112052 (e-PCR)
- UniSTS:183637

SHGC-35216 (e-PCR)
- UniSTS:13921

D3S2498 (e-PCR)
- UniSTS:150114

D3S2499 (e-PCR)
- UniSTS:150115

RH120311 (e-PCR)
- UniSTS:132452

D3S2500 (e-PCR)
- UniSTS:150116

D3S2503 (e-PCR)
- UniSTS:150119

D3S2504 (e-PCR)
- UniSTS:150120

D3S2505 (e-PCR)
- UniSTS:150121

SHGC-146035 (e-PCR)
- UniSTS:174953

D11S3972 (e-PCR)
- UniSTS:6762

D3S2507 (e-PCR)
- UniSTS:150123

D3S2509 (e-PCR)
- UniSTS:150125

D3S2510 (e-PCR)
- UniSTS:150126

D3S2511 (e-PCR)
- UniSTS:150127

D3S2512 (e-PCR)
- UniSTS:150128

D3S2513 (e-PCR)
- UniSTS:150129

D15S1477 (e-PCR)
- UniSTS:474482

D3S2514 (e-PCR)
- UniSTS:150130

D3S2975 (e-PCR)
- UniSTS:49526

SHGC-77117 (e-PCR)
- UniSTS:66689

SHGC-111359 (e-PCR)
- UniSTS:168326

SHGC-111365 (e-PCR)
- UniSTS:168331

G35125 (e-PCR)
- UniSTS:47503

G63203 (e-PCR)
- UniSTS:140177

SHGC-112294 (e-PCR)
- UniSTS:168596

D3S2552 (e-PCR)
- UniSTS:150168

D3S4492 (e-PCR)
- UniSTS:474524

D3S3 (e-PCR)
- UniSTS:146848

D3S3474E (e-PCR)
- UniSTS:154020

RH44887 (e-PCR)
- UniSTS:27816

SHGC-10600 (e-PCR)
- UniSTS:40874

D3S3962 (e-PCR)
- UniSTS:60849

D3S3681 (e-PCR), detects polymorphism
- UniSTS:57782

RH119517 (e-PCR)
- UniSTS:133559

D3S3073 (e-PCR)
- UniSTS:62156

D3S3049 (e-PCR), detects polymorphism
- UniSTS:1236

G19159 (e-PCR)
- UniSTS:18901

G59233 (e-PCR)
- UniSTS:136406

RH47423 (e-PCR)
- UniSTS:57047

D3S1669 (e-PCR)
- UniSTS:148443

RH120016 (e-PCR)
- UniSTS:133340

RH16327 (e-PCR)
- UniSTS:26594

SHGC-110573 (e-PCR)
- UniSTS:167911

SHGC-70139 (e-PCR)
- UniSTS:183783

D3S1604 (e-PCR), detects polymorphism
- UniSTS:24554

D3S1604 (e-PCR), detects polymorphism
- UniSTS:24555

SHGC-154706 (e-PCR)
- UniSTS:178164

SHGC-110600 (e-PCR)
- UniSTS:167930

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables LRR domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables axon guidance receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Roundabout signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aorta development	ISS Inferred from Sequence or Structural Similarity more info
involved_in aortic valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon midline choice point recognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration	IDA Inferred from Direct Assay more info	PubMed
involved_in endocardial cushion formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart induction	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chemokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mammary gland epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of negative chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pulmonary valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: roundabout homolog 1

Names: deleted in U twenty twenty; roundabout, axon guidance receptor, homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011729.1 RefSeqGene

Range

4912..1175671

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001145845.2 → NP_001139317.1 roundabout homolog 1 isoform d precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, includes an alternate in-frame exon in the 5' coding region, lacks an alternate in-frame exon in the central coding region, and uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and differs at three internal regions, compared to isoform a. The 5' UTR of this variant contains a 55 aa uORF with a strong Kozak signal that may inhibit translation of this protein.

Source sequence(s)

AC016946, AC055731, AC106720, AC108719, AK025535, BC115022, BP228659

Consensus CDS

CCDS54610.1

UniProtKB/TrEMBL

Q2M1J3

Related

ENSP00000417992.1, ENST00000467549.5

Conserved Domains (7) summary

cd00063
Location:525 → 611

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:742 → 828

fn3; Fibronectin type III domain

cd05724
Location:134 → 219

IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd05725
Location:226 → 308

IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd05726
Location:316 → 413

IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains

cd07693
Location:29 → 127

IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains

cd20952
Location:420 → 506

IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
NM_002941.4 → NP_002932.1 roundabout homolog 1 isoform a precursor

See identical proteins and their annotated locations for NP_002932.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC125624, AF040990, AK025535, DR003097

Consensus CDS

CCDS54611.1

UniProtKB/Swiss-Prot

B2RXI1, D3DU36, E9PD49, Q1RMC7, Q7Z300, Q9BUS7, Q9Y6N7

UniProtKB/TrEMBL

Q2M1J3

Related

ENSP00000420321.1, ENST00000464233.6

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:365 → 454

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:561 → 647

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:778 → 864

fn3; Fibronectin type III domain

cl11960
Location:459 → 533

Ig; Immunoglobulin domain
NM_133631.4 → NP_598334.2 roundabout homolog 1 isoform b precursor

See identical proteins and their annotated locations for NP_598334.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, includes an alternate in-frame exon in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus, compared to isoform a. The 5' UTR of this variant contains a 55 aa uORF with a strong Kozak signal that may inhibit translation of this protein.

Source sequence(s)

AC016946, BC029676, BC115020, BC157861, BP228659

Consensus CDS

CCDS46872.2

UniProtKB/TrEMBL

Q2M1J3

Related

ENSP00000420637.1, ENST00000495273.5

Conserved Domains (8) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:329 → 418

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:525 → 611

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:223 → 308

I-set; Immunoglobulin I-set domain

pfam00041
Location:742 → 828

fn3; Fibronectin type III domain

cl11960
Location:423 → 497

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

78597239..79767998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017006982.2 → XP_016862471.1 roundabout homolog 1 isoform X4

UniProtKB/TrEMBL

Q2M1J3
XM_047448664.1 → XP_047304620.1 roundabout homolog 1 isoform X12
XM_047448661.1 → XP_047304617.1 roundabout homolog 1 isoform X3
XM_017006984.1 → XP_016862473.1 roundabout homolog 1 isoform X10

UniProtKB/TrEMBL

Q2M1J3
XM_011533980.1 → XP_011532282.1 roundabout homolog 1 isoform X11

UniProtKB/TrEMBL

Q2M1J3

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:781 → 867

fn3; Fibronectin type III domain

cl11960
Location:462 → 536

Ig; Immunoglobulin domain
XM_011533978.1 → XP_011532280.1 roundabout homolog 1 isoform X2

UniProtKB/TrEMBL

Q2M1J3

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:781 → 867

fn3; Fibronectin type III domain

cl11960
Location:462 → 536

Ig; Immunoglobulin domain
XM_011533979.1 → XP_011532281.1 roundabout homolog 1 isoform X9

UniProtKB/TrEMBL

Q2M1J3

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:781 → 867

fn3; Fibronectin type III domain

cl11960
Location:462 → 536

Ig; Immunoglobulin domain
XM_011533976.1 → XP_011532278.1 roundabout homolog 1 isoform X1

See identical proteins and their annotated locations for XP_011532278.1

UniProtKB/TrEMBL

Q2M1J3

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:781 → 867

fn3; Fibronectin type III domain

cl11960
Location:462 → 536

Ig; Immunoglobulin domain
XM_011533977.3 → XP_011532279.1 roundabout homolog 1 isoform X1

See identical proteins and their annotated locations for XP_011532279.1

UniProtKB/TrEMBL

Q2M1J3

Conserved Domains (8) summary

cd05724
Location:174 → 258

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:279 → 347

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:368 → 457

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:67 → 166

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:564 → 650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:262 → 347

I-set; Immunoglobulin I-set domain

pfam00041
Location:781 → 867

fn3; Fibronectin type III domain

cl11960
Location:462 → 536

Ig; Immunoglobulin domain
XM_047448665.1 → XP_047304621.1 roundabout homolog 1 isoform X13
XM_047448663.1 → XP_047304619.1 roundabout homolog 1 isoform X8
XM_017006983.3 → XP_016862472.1 roundabout homolog 1 isoform X7

UniProtKB/TrEMBL

Q2M1J3

Related

ENSP00000406043.3, ENST00000436010.6

Conserved Domains (8) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:326 → 415

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:522 → 608

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:223 → 308

I-set; Immunoglobulin I-set domain

pfam00041
Location:739 → 825

fn3; Fibronectin type III domain

cl11960
Location:420 → 494

Ig; Immunoglobulin domain
XM_006713277.4 → XP_006713340.1 roundabout homolog 1 isoform X5

UniProtKB/TrEMBL

Q2M1J3

Conserved Domains (8) summary

cd05724
Location:135 → 219

Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05725
Location:240 → 308

Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd05726
Location:329 → 418

Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors

cd07693
Location:28 → 127

Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins

cd00063
Location:525 → 611

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:223 → 308

I-set; Immunoglobulin I-set domain

pfam00041
Location:742 → 828

fn3; Fibronectin type III domain

cl11960
Location:423 → 497

Ig; Immunoglobulin domain
XM_017006985.2 → XP_016862474.1 roundabout homolog 1 isoform X14

UniProtKB/TrEMBL

A0A0A0MSX4
XM_047448662.1 → XP_047304618.1 roundabout homolog 1 isoform X6