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    SGK1 serum/glucocorticoid regulated kinase 1 [ Homo sapiens (human) ]

    Gene ID: 6446, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SGK1provided by HGNC
    Official Full Name
    serum/glucocorticoid regulated kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:10810
    See related
    Ensembl:ENSG00000118515 MIM:602958; AllianceGenome:HGNC:10810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGK
    Summary
    This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
    Expression
    Broad expression in small intestine (RPKM 111.9), gall bladder (RPKM 85.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    6q23.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (134169256..134318112, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (135357191..135506235, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134490394..134639250, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901404 Neighboring gene high mobility group AT-hook 1 pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 408, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr6:134481640-134482141 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:134496091-134496592 Neighboring gene Sharpr-MPRA regulatory region 71 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein S29 pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25086 Neighboring gene RNA, 5S ribosomal pseudogene 218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:134617783-134618284 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:134632359-134632918 Neighboring gene keratin 8 pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25089 Neighboring gene uncharacterized LOC105378009 Neighboring gene SGK1-CHCHD2P4 intergenic CAGE-defined mid-level expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17559 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [SGK1 as a therapeutic target for central nervous system diseases]. Xing YK, et al. Sheng Li Xue Bao, 2023 Jun 25. PMID 37340653
    2. Induction of SGK1 via glucocorticoid-influenced clinical outcome of triple-negative breast cancer patients. Zhang J, et al. Breast Cancer Res Treat, 2023 Aug. PMID 37286891
    3. Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2. Giannetti F, et al. Europace, 2023 May 19. PMID 37099628, Free PMC Article
    4. SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells. Hara Y, et al. Blood Adv, 2023 Jun 13. PMID 36696461, Free PMC Article
    5. Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation. Bapat A, et al. JCI Insight, 2022 Oct 10. PMID 35998035, Free PMC Article

    See all (295) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.
      Title: SGK1 aggravates idiopathic pulmonary fibrosis by triggering H3k27ac-mediated macrophage reprogramming and disturbing immune homeostasis.
    2. Proteomics on malignant pleural effusions reveals ERalpha loss in metastatic breast cancer associates with SGK1-NDRG1 deregulation.
      Title: Proteomics on malignant pleural effusions reveals ERα loss in metastatic breast cancer associates with SGK1-NDRG1 deregulation.
    3. Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy.
      Title: Circular RNA COL1A2 Mediates High Glucose-Induced Oxidative Stress and Pyroptosis by Regulating MiR-424-5p/SGK1 in Diabetic Nephropathy.
    4. Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion.
      Title: Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion.
    5. Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
      Title: Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
    6. Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases.
      Title: Role of Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases.
    7. Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation.
      Title: Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation.
    8. Induction of SGK1 via glucocorticoid-influenced clinical outcome of triple-negative breast cancer patients.
      Title: Induction of SGK1 via glucocorticoid-influenced clinical outcome of triple-negative breast cancer patients.
    9. [SGK1 as a therapeutic target for central nervous system diseases].
      Title: [SGK1 as a therapeutic target for central nervous system diseases].
    10. ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.
      Title: ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.
    Submit: New GeneRIF Correction See all GeneRIFs (227)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
    EBI GWAS Catalog
    Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
    EBI GWAS Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies serum/glucocorticoid regulated kinase SGK1 is important for HIV-1 replication PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables chloride channel regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium channel regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to aldosterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term memory TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of blood pressure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of catalytic activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell growth TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of gastric acid secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
    		  
    involved_in renal sodium ion absorption TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sodium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Sgk1
    Names
    serine/threonine protein kinase SGK
    NP_001137148.1
    NP_001137149.1
    NP_001137150.1
    NP_001278924.1
    NP_005618.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143676.3 → NP_001137148.1  serine/threonine-protein kinase Sgk1 isoform 2

      See identical proteins and their annotated locations for NP_001137148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains additional in-frame exons at the 5' end compared to transcript variant 1, resulting in an isoform (2) with a longer and an unique N-terminus compared to isoform 1. Isoform 2 is reported to have an increased protein half-life, and is preferentially targeted to the plasma membrane.
      Source sequence(s)
      AL135839, AL355881, Z84486
      Consensus CDS
      CCDS47476.1
      UniProtKB/Swiss-Prot
      O00141
      Related
      ENSP00000356832.5, ENST00000367858.10
      Conserved Domains (2) summary
      smart00220
      Location:193 → 450
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05575
      Location:197 → 519
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

    2. NM_001143677.2 → NP_001137149.1  serine/threonine-protein kinase Sgk1 isoform 3

      See identical proteins and their annotated locations for NP_001137149.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (3) with a longer and an unique N-terminus compared to isoform 1.
      Source sequence(s)
      AK098509, BP384292, DA309338
      Consensus CDS
      CCDS47477.1
      UniProtKB/Swiss-Prot
      O00141
      Related
      ENSP00000434450.1, ENST00000528577.5
      Conserved Domains (1) summary
      cd05575
      Location:130 → 452
      STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

    3. NM_001143678.2 → NP_001137150.1  serine/threonine-protein kinase Sgk1 isoform 4

      See identical proteins and their annotated locations for NP_001137150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (4) with a longer and an unique N-terminus compared to isoform 1.
      Source sequence(s)
      AK098509, BP384292, DC428953
      Consensus CDS
      CCDS47478.1
      UniProtKB/TrEMBL
      B7Z325
      Related
      ENSP00000396242.3, ENST00000413996.7
      Conserved Domains (1) summary
      cd05602
      Location:104 → 442
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    4. NM_001291995.2 → NP_001278924.1  serine/threonine-protein kinase Sgk1 isoform 5

      See identical proteins and their annotated locations for NP_001278924.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF153609, AK295422, DB450096
      Consensus CDS
      CCDS78184.1
      UniProtKB/TrEMBL
      B7Z325, E9PR89
      Related
      ENSP00000434302.1, ENST00000475719.6
      Conserved Domains (1) summary
      cl21453
      Location:90 → 384
      PKc_like; Protein Kinases, catalytic domain

    5. NM_005627.4 → NP_005618.2  serine/threonine-protein kinase Sgk1 isoform 1

      See identical proteins and their annotated locations for NP_005618.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the shortest isoform (1).
      Source sequence(s)
      AK098509, BP384292, DB450096
      Consensus CDS
      CCDS5170.1
      UniProtKB/Swiss-Prot
      B7UUP7, B7UUP8, B7UUP9, B7Z5B2, E1P583, O00141, Q5TCN2, Q5TCN3, Q5TCN4, Q5VY65, Q9UN56
      UniProtKB/TrEMBL
      B7Z325
      Related
      ENSP00000237305.7, ENST00000237305.12
      Conserved Domains (1) summary
      cd05602
      Location:90 → 428
      STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      134169256..134318112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      135357191..135506235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00141.2 GenPept UniProtKB/Swiss-Prot:O00141

    Gene LinkOut

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