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    KDM6A lysine demethylase 6A [ Homo sapiens (human) ]

    Gene ID: 7403, updated on 7-Apr-2024

    Summary

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    Official Symbol
    KDM6Aprovided by HGNC
    Official Full Name
    lysine demethylase 6Aprovided by HGNC
    Primary source
    HGNC:HGNC:12637
    See related
    Ensembl:ENSG00000147050 MIM:300128; AllianceGenome:HGNC:12637
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UTX; KABUK2; bA386N14.2
    Summary
    This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 10.3), thyroid (RPKM 7.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    Xp11.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (44873188..45112779)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (44280009..44519820)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (44732434..44972024)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20786 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:44738216-44738357 Neighboring gene dual specificity phosphatase 21 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:44811731-44812256 Neighboring gene Sharpr-MPRA regulatory region 12888 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:44834497-44835696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29568 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:44900925-44901669 Neighboring gene divergent protein kinase domain 2B Neighboring gene uncharacterized LOC105373191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types. Sun W, et al. Epigenetics, 2023 Dec. PMID 37300822, Free PMC Article
    2. Differential Occupancy and Regulatory Interactions of KDM6A in Bladder Cell Lines. Özden-Yılmaz G, et al. Cells, 2023 Mar 8. PMID 36980177, Free PMC Article
    3. The role of lysine-specific demethylase 6A (KDM6A) in tumorigenesis and its therapeutic potentials in cancer therapy. Chen LJ, et al. Bioorg Chem, 2023 Apr. PMID 36753963
    4. KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. Boila LD, et al. Leukemia, 2023 Apr. PMID 36720973
    5. KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer. Qiu H, et al. Cancer Res, 2023 Mar 15. PMID 36638328, Free PMC Article

    See all (200) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Clinical characteristics and genetic counseling for a three-generation Chinese pedigree with recurrent fetal Kabuki syndrome due to variant of KDM6A gene].
      Title: [Clinical characteristics and genetic counseling for a three-generation Chinese pedigree with recurrent fetal Kabuki syndrome due to variant of KDM6A gene].
    2. SETting up the genome: KMT2D and KDM6A genomic function in the Kabuki syndrome craniofacial developmental disorder.
      Title: SETting up the genome: KMT2D and KDM6A genomic function in the Kabuki syndrome craniofacial developmental disorder.
    3. Downregulation of lncRNA XIST may promote Th17 differentiation through KDM6A-TSAd pathway in neuromyelitis optica spectrum disorders.
      Title: Downregulation of lncRNA XIST may promote Th17 differentiation through KDM6A-TSAd pathway in neuromyelitis optica spectrum disorders.
    4. The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.
      Title: The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.
    5. Lysine-specific Demethylase 6A Upregulates Cadherin-1 and Accelerates Gastric Cancer Growth.
      Title: Lysine-specific Demethylase 6A Upregulates Cadherin-1 and Accelerates Gastric Cancer Growth.
    6. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.
      Title: The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.
    7. Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types.
      Title: Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types.
    8. Downregulated KDM6A mediates gastric carcinogenesis via Wnt/beta-catenin signaling pathway mediated epithelial-to-mesenchymal transition.
      Title: Downregulated KDM6A mediates gastric carcinogenesis via Wnt/β-catenin signaling pathway mediated epithelial-to-mesenchymal transition.
    9. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences.
      Title: The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences.
    10. Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/beta-Catenin Pathway in Gastric Cancer.
      Title: Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (139)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Kabuki syndrome 1
    MedGen: CN030661 OMIM: 147920 GeneReviews: Kabuki Syndrome
    		Compare labs
    Kabuki syndrome 2
    MedGen: C3275495 OMIM: 300867 GeneReviews: Kabuki Syndrome
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2013-07-18)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2013-07-18)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates expression of KDM6A (UTX1) in TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141941, DKFZp686A03225

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K27me2/H3K27me3 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone demethylase activity TAS
    Traceable Author Statement
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MLL3/4 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysine-specific demethylase 6A
    Names
    [histone H3]-trimethyl-L-lysine(27) demethylase 6A
    bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))
    histone demethylase UTX
    lysine (K)-specific demethylase 6A
    ubiquitously transcribed tetratricopeptide repeat protein X-linked
    ubiquitously-transcribed TPR gene on the X chromosome
    NP_001278344.1
    NP_001278345.1
    NP_001278346.1
    NP_001278347.1
    NP_001278350.1
    NP_001397671.1
    NP_001406738.1
    NP_001406739.1
    NP_001406740.1
    NP_001406741.1
    NP_001406742.1
    NP_001406743.1
    NP_001406744.1
    NP_066963.2
    XP_011542271.1
    XP_011542274.1
    XP_011542276.1
    XP_016885272.1
    XP_024308207.1
    XP_047298384.1
    XP_047298385.1
    XP_047298386.1
    XP_047298387.1
    XP_054183677.1
    XP_054183679.1
    XP_054183680.1
    XP_054183682.1
    XP_054183683.1
    XP_054183684.1
    XP_054183685.1
    XP_054183686.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016260.1 RefSeqGene

      Range
      4999..244435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_616

    mRNA and Protein(s)

    1. NM_001291415.2 → NP_001278344.1  lysine-specific demethylase 6A isoform 1

      See identical proteins and their annotated locations for NP_001278344.1

      Status: REVIEWED

      Source sequence(s)
      AC136488, AL133545, AL138744
      Consensus CDS
      CCDS94599.1
      UniProtKB/TrEMBL
      A0A087X0R0, B7ZKN5
      Related
      ENSP00000483595.2, ENST00000611820.5
      Conserved Domains (6) summary
      pfam02373
      Location:1185 → 1293
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1151 → 1215
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:130 → 163
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:272 → 303
      TPR_17; Tetratricopeptide repeat

    2. NM_001291416.2 → NP_001278345.1  lysine-specific demethylase 6A isoform 2

      See identical proteins and their annotated locations for NP_001278345.1

      Status: REVIEWED

      Source sequence(s)
      AC136488, AI364446, AL041377, AL831996, BC143272, BC143278, DC381812
      Consensus CDS
      CCDS94601.1
      UniProtKB/TrEMBL
      B7ZKN1, F8W8R6
      Related
      ENSP00000372355.6, ENST00000382899.9
      Conserved Domains (6) summary
      pfam02373
      Location:1140 → 1248
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1106 → 1170
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 401
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:130 → 163
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:272 → 303
      TPR_17; Tetratricopeptide repeat

    3. NM_001291417.2 → NP_001278346.1  lysine-specific demethylase 6A isoform 4

      See identical proteins and their annotated locations for NP_001278346.1

      Status: REVIEWED

      Source sequence(s)
      AC136488, AI364446, AK303430, AL041377, AL831996, BC143278, DC381812
      Consensus CDS
      CCDS94603.1
      UniProtKB/TrEMBL
      B7ZKN6, F5H6S1
      Related
      ENSP00000437405.3, ENST00000536777.6
      Conserved Domains (7) summary
      pfam02373
      Location:1088 → 1196
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1054 → 1118
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:130 → 163
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:317 → 378
      TPR_11; TPR repeat
      pfam13424
      Location:205 → 282
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:272 → 303
      TPR_17; Tetratricopeptide repeat

    4. NM_001291418.2 → NP_001278347.1  lysine-specific demethylase 6A isoform 5

      See identical proteins and their annotated locations for NP_001278347.1

      Status: REVIEWED

      Source sequence(s)
      AB208795, AC136488, AI364446, AL041377, BC143278, DC381812, DQ062677
      Consensus CDS
      CCDS94604.1
      UniProtKB/TrEMBL
      E1U0S6, F5H5V6
      Related
      ENSP00000443078.3, ENST00000543216.6
      Conserved Domains (7) summary
      pfam02373
      Location:1054 → 1162
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1020 → 1084
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:130 → 163
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:317 → 378
      TPR_11; TPR repeat
      pfam13424
      Location:205 → 282
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:272 → 303
      TPR_17; Tetratricopeptide repeat

    5. NM_001291421.2 → NP_001278350.1  lysine-specific demethylase 6A isoform 6

      See identical proteins and their annotated locations for NP_001278350.1

      Status: REVIEWED

      Source sequence(s)
      AC136488, AI364446, AL041377, AL831996, BC143275, BC143278, DC381812
      UniProtKB/TrEMBL
      A0A6Q8PG32
      Related
      ENST00000675157.1
      Conserved Domains (4) summary
      smart00558
      Location:803 → 867
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG4235
      Location:18 → 121
      NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:34 → 61
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:837 → 945
      JmjC; JmjC domain, hydroxylase

    6. NM_001410742.1 → NP_001397671.1  lysine-specific demethylase 6A isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC136488, AL133545, AL138744
      Consensus CDS
      CCDS94600.1
      UniProtKB/TrEMBL
      A0A6Q8PFK0
      Related
      ENSP00000501855.1, ENST00000675577.1

    7. NM_001419809.1 → NP_001406738.1  lysine-specific demethylase 6A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC136488, AL133545, AL138744

    8. NM_001419810.1 → NP_001406739.1  lysine-specific demethylase 6A isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC136488, AL133545, AL138744

    9. NM_001419811.1 → NP_001406740.1  lysine-specific demethylase 6A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC136488, AL133545, AL138744
      Related
      ENSP00000502311.1, ENST00000676062.1

    10. NM_001419812.1 → NP_001406741.1  lysine-specific demethylase 6A isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC136488, AL133545, AL138744

    11. NM_001419813.1 → NP_001406742.1  lysine-specific demethylase 6A isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC136488, AL133545, AL138744

    12. NM_001419814.1 → NP_001406743.1  lysine-specific demethylase 6A isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC136488, AL133545, AL138744

    13. NM_001419815.1 → NP_001406744.1  lysine-specific demethylase 6A isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC136488, AL133545, AL138744

    14. NM_021140.4 → NP_066963.2  lysine-specific demethylase 6A isoform 3

      See identical proteins and their annotated locations for NP_066963.2

      Status: REVIEWED

      Source sequence(s)
      AB208795, AC136488, AI364446, AL041377, DC381812
      Consensus CDS
      CCDS14265.1
      UniProtKB/Swiss-Prot
      O15550, Q52LL9, Q5JVQ7
      UniProtKB/TrEMBL
      Q59HG3
      Related
      ENSP00000367203.4, ENST00000377967.9
      Conserved Domains (4) summary
      pfam02373
      Location:1133 → 1241
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1099 → 1163
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]

    RNA

    1. NR_111960.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB208795, AC136488, AI364446, AK303430, AL041377, BC143272, DC381812, EU026291
      Related
      ENST00000674564.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      44873188..45112779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543969.4 → XP_011542271.1  lysine-specific demethylase 6A isoform X6

      UniProtKB/TrEMBL
      B7ZKN1
      Conserved Domains (6) summary
      pfam02373
      Location:1106 → 1214
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1072 → 1136
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 401
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:130 → 163
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:272 → 303
      TPR_17; Tetratricopeptide repeat

    2. XM_017029783.3 → XP_016885272.1  lysine-specific demethylase 6A isoform X9

      UniProtKB/TrEMBL
      A0A804HJA2, B7ZKN1
      Related
      ENSP00000507416.1, ENST00000683021.1
      Conserved Domains (6) summary
      pfam02373
      Location:1106 → 1214
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1072 → 1136
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 401
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:130 → 163
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:272 → 303
      TPR_17; Tetratricopeptide repeat

    3. XM_011543972.4 → XP_011542274.1  lysine-specific demethylase 6A isoform X8

      UniProtKB/TrEMBL
      B7ZKN6
      Conserved Domains (7) summary
      pfam02373
      Location:1088 → 1196
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1054 → 1118
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:130 → 163
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:317 → 378
      TPR_11; TPR repeat
      pfam13424
      Location:205 → 282
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:272 → 303
      TPR_17; Tetratricopeptide repeat

    4. XM_011543974.3 → XP_011542276.1  lysine-specific demethylase 6A isoform X12

      UniProtKB/TrEMBL
      A0A6Q8PGN0
      Conserved Domains (6) summary
      pfam02373
      Location:1133 → 1241
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1099 → 1163
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:130 → 163
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:272 → 303
      TPR_17; Tetratricopeptide repeat

    5. XM_047442430.1 → XP_047298386.1  lysine-specific demethylase 6A isoform X14

    6. XM_047442431.1 → XP_047298387.1  lysine-specific demethylase 6A isoform X15

    7. XM_024452439.2 → XP_024308207.1  lysine-specific demethylase 6A isoform X11

      UniProtKB/TrEMBL
      A0A6Q8PG32
      Conserved Domains (4) summary
      pfam02373
      Location:1010 → 1118
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:976 → 1040
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:7 → 224
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:110 → 137
      TPR; TPR repeat [structural motif]

    8. XM_047442429.1 → XP_047298385.1  lysine-specific demethylase 6A isoform X13

    9. XM_047442428.1 → XP_047298384.1  lysine-specific demethylase 6A isoform X11

      Related
      ENST00000676389.1

    RNA

    1. XR_007068200.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      44280009..44519820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327702.1 → XP_054183677.1  lysine-specific demethylase 6A isoform X6

    2. XM_054327705.1 → XP_054183680.1  lysine-specific demethylase 6A isoform X9

      UniProtKB/TrEMBL
      A0A804HJA2

    3. XM_054327704.1 → XP_054183679.1  lysine-specific demethylase 6A isoform X8

    4. XM_054327708.1 → XP_054183683.1  lysine-specific demethylase 6A isoform X12

    5. XM_054327710.1 → XP_054183685.1  lysine-specific demethylase 6A isoform X14

    6. XM_054327711.1 → XP_054183686.1  lysine-specific demethylase 6A isoform X15

    7. XM_054327707.1 → XP_054183682.1  lysine-specific demethylase 6A isoform X11

    8. XM_054327709.1 → XP_054183684.1  lysine-specific demethylase 6A isoform X13

    RNA

    1. XR_008485506.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15550.2 GenPept UniProtKB/Swiss-Prot:O15550

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