Gpr20 G protein-coupled receptor 20 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr20provided by RGD
Official Full Name: G protein-coupled receptor 20provided by RGD
Primary source: RGD:620034
See related: AllianceGenome:RGD:620034
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2Y4; Gpcr5-1
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be located in cytosol and plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be part of receptor complex. Orthologous to human GPR20 (G protein-coupled receptor 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 6.3), Muscle (RPKM 5.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (107490419..107500993, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (105601761..105611959, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (114943675..114953977, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR20 constitutively activates G(i) proteins without ligand stimulation
Title: Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins.
second extracellular loop and the NH(2) terminus form a functional motif that plays a key role in determining whether ATP functions as an agonist or antagonist at mammalian P2Y(4) receptors
Title: Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled receptor 20

Names: G protein-coupled receptor 5-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022216.2 → NP_071552.2 G-protein coupled receptor 20

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

O35797

Conserved Domains (1) summary

cd15163
Location:52 → 307

7tmA_GPR20; G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors