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    hsp-6 Heat shock protein hsp-6 [ Caenorhabditis elegans ]

    Gene ID: 178873, updated on 11-Apr-2024

    Summary

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    Gene symbol
    hsp-6
    Gene description
    Heat shock protein hsp-6
    Primary source
    WormBase:WBGene00002010
    Locus tag
    CELE_C37H5.8
    See related
    AllianceGenome:WB:WBGene00002010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Involved in mitochondrial unfolded protein response. Located in mitochondrion. Is expressed in intestine and muscle cell. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (4824124..4826760, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Adenylosuccinate synthetase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nucleolar complex protein 3 homolog Neighboring gene Decapping nuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Potential toxicity of nanopolystyrene on lifespan and aging process of nematode Caenorhabditis elegans. Qiu Y, et al. Sci Total Environ, 2020 Feb 25. PMID 31837847
    2. Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. Yokoyama K, et al. FEBS Lett, 2002 Apr 10. PMID 11959102
    3. Compromised Mitochondrial Protein Import Acts as a Signal for UPR(mt). Rolland SG, et al. Cell Rep, 2019 Aug 13. PMID 31412237
    4. Joint mouse-human phenome-wide association to test gene function and disease risk. Wang X, et al. Nat Commun, 2016 Feb 2. PMID 26833085, Free PMC Article
    5. Caffeine Induces the Stress Response and Up-Regulates Heat Shock Proteins in Caenorhabditis elegans. Al-Amin M, et al. Mol Cells, 2016 Feb. PMID 26743903, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial unfolded protein response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitochondrial unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Heat shock protein hsp-6
    NP_001370558.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4824124..4826760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383301.1 → NP_001370558.1  Heat shock protein hsp-6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11141, P91135
      Conserved Domains (1) summary
      PRK00290
      Location:30 → 646
      dnaK; molecular chaperone DnaK; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11141.2

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