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FAM213B family with sequence similarity 213, member B [ Homo sapiens (human) ]

Gene ID: 127281, updated on 19-Jul-2014
Official Symbol
FAM213Bprovided by HGNC
Official Full Name
family with sequence similarity 213, member Bprovided by HGNC
Primary source
HGNC:28390
Locus tag
RP3-395M20.10
See related
Ensembl:ENSG00000157870; HPRD:14513; Vega:OTTHUMG00000000847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf93
See FAM213B in Epigenomics, MapViewer
Location:
1p36.32
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (2586460..2591469)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2517899..2522908)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115110 Neighboring gene uncharacterized LOC100996583 Neighboring gene tumor necrosis factor receptor superfamily, member 14 Neighboring gene membrane metallo-endopeptidase-like 1 Neighboring gene uncharacterized LOC101929067 Neighboring gene tetratricopeptide repeat domain 34 Neighboring gene actin-related protein T2

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26818, DKFZp547M123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin-F synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
prostamide/prostaglandin F synthase
Names
prostamide/prostaglandin F synthase
prostamide/PGF synthase
prostamide/PG F synthase
NP_001182665.1
NP_001182666.1
NP_001182667.1
NP_001182669.1
NP_001182670.1
NP_689584.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195736.1NP_001182665.1  prostamide/prostaglandin F synthase isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
    Source sequence(s)
    AK057027, AK075273, BM976058, DC351872, DC407959
    UniProtKB/Swiss-Prot
    Q8TBF2
    Related
    ENSP00000413218, ENST00000444521
    Conserved Domains (1) summary
    cd02970
    Location:48215
    Blast Score: 297
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  2. NM_001195737.1NP_001182666.1  prostamide/prostaglandin F synthase isoform c

    See proteins identical to NP_001182666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses three different splice sites in the coding region, compared to variant 1. The resulting protein (isoform c) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK303504, BM976058, DC351872, DC407959
    UniProtKB/Swiss-Prot
    Q8TBF2
    Conserved Domains (1) summary
    cd02970
    Location:48153
    Blast Score: 270
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  3. NM_001195738.1NP_001182667.1  prostamide/prostaglandin F synthase isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two different splice sites in the coding region which changes the reading frame, compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK291908, BM976058, DC351872, DC407959
    UniProtKB/Swiss-Prot
    Q8TBF2
    Related
    ENSP00000367684, OTTHUMP00000000970, ENST00000378427, OTTHUMT00000002403
    Conserved Domains (1) summary
    cd02970
    Location:48184
    Blast Score: 308
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  4. NM_001195740.1NP_001182669.1  prostamide/prostaglandin F synthase isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK316243, BM976058, DC351872, DC407959
    UniProtKB/Swiss-Prot
    Q8TBF2
    Conserved Domains (1) summary
    cd02970
    Location:48153
    Blast Score: 270
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  5. NM_001195741.1NP_001182670.1  prostamide/prostaglandin F synthase isoform f

    See proteins identical to NP_001182670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK298926, BM976058, DC351872, DC407959
    Consensus CDS
    CCDS55564.1
    UniProtKB/Swiss-Prot
    Q8TBF2
    Conserved Domains (1) summary
    cd02970
    Location:48153
    Blast Score: 269
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  6. NM_152371.3NP_689584.2  prostamide/prostaglandin F synthase isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in an internal coding region exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, BC022547, BM976058, DC351872, DC407959
    Consensus CDS
    CCDS44.2
    UniProtKB/Swiss-Prot
    Q8TBF2
    Related
    ENSP00000394405, OTTHUMP00000000968, ENST00000419916, OTTHUMT00000002401
    Conserved Domains (1) summary
    cd02970
    Location:48197
    Blast Score: 326
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RNA

  1. NR_036637.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate 5'-most exon and an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK075273, BM976058, BQ709693, DA495138
  2. NR_036638.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate 5'-most exon and two alternate internal splice sites, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK075273, BI908668, BM976058, DA292832, DA495138

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_187515.1 

    Range
    137650..142659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724944.1XP_006725007.1  

    See proteins identical to XP_006725007.1

    Conserved Domains (1) summary
    cd02970
    Location:48153
    Blast Score: 272
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    2586460..2591469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710354.1XP_006710417.1  

    See proteins identical to XP_006710417.1

    Conserved Domains (1) summary
    cd02970
    Location:48153
    Blast Score: 272
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    1797135..1802144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    2504978..2509987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)