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    Azin1 antizyme inhibitor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58961, updated on 22-Dec-2015
    Official Symbol
    Azin1provided by RGD
    Official Full Name
    antizyme inhibitor 1provided by RGD
    Primary source
    RGD:61934
    See related
    Ensembl:ENSRNOG00000005333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oazi; Oazin
    Summary
    The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
    Orthologs
    See Azin1 in MapViewer
    Location:
    7q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (77345671..77372393, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (77448669..77475344, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550687 Neighboring gene ring finger protein 149 Neighboring gene zinc finger, CCHC domain containing 10-like Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit C1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    ornithine decarboxylase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ornithine decarboxylase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    ornithine decarboxylase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    ornithine decarboxylase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT ornithine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    negative regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    polyamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of polyamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of polyamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    putrescine biosynthetic process from ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    antizyme inhibitor 1
    Names
    AZI
    ornithine decarboxylase antizyme inhibitor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301702.1NP_001288631.1  antizyme inhibitor 1

      See identical proteins and their annotated locations for NP_001288631.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal 5' non-coding exon, thus has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AABR07057563
      UniProtKB/TrEMBL
      Q6P7R3
      Conserved Domains (2) summary
      cd06831
      Location:26419
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
      COG0019
      Location:40405
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
    2. NM_022585.2NP_072107.2  antizyme inhibitor 1

      See identical proteins and their annotated locations for NP_072107.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AABR07057563
      UniProtKB/TrEMBL
      Q6P7R3
      Related
      ENSRNOP00000007999, ENSRNOT00000007999
      Conserved Domains (2) summary
      cd06831
      Location:26419
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
      COG0019
      Location:40405
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      77345671..77372393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765457.1XP_008763679.1  

      See identical proteins and their annotated locations for XP_008763679.1

      UniProtKB/TrEMBL
      Q6P7R3
      Conserved Domains (2) summary
      cd06831
      Location:26419
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
      COG0019
      Location:40405
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
    2. XM_006241569.2XP_006241631.1  

      Conserved Domains (2) summary
      cd06831
      Location:26418
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
      COG0019
      Location:40404
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
    3. XM_006241567.2XP_006241629.1  

      Related
      ENSRNOP00000069785, ENSRNOT00000079644
      Conserved Domains (2) summary
      cd06831
      Location:26419
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
      COG0019
      Location:40405
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
    4. XM_006241568.2XP_006241630.1  

      See identical proteins and their annotated locations for XP_006241630.1

      UniProtKB/TrEMBL
      Q6P7R3
      Conserved Domains (2) summary
      cd06831
      Location:26419
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
      COG0019
      Location:40405
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      66713099..66739814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)