Display Settings:

Format

Send to:

Choose Destination

C5ar1 complement component 5a receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 12273, updated on 26-Apr-2015
Official Symbol
C5ar1provided by MGI
Official Full Name
complement component 5a receptor 1provided by MGI
Primary source
MGI:MGI:88232
See related
Ensembl:ENSMUSG00000049130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C5aR; C5r1; Cd88; D7Msu1
Orthologs
See C5ar1 in MapViewer
Location:
7 A2; 7 8.77 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (16246743..16259540, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (16832092..16844889, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 34 Neighboring gene complement component 5a receptor 2 Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9 Neighboring gene BCL2 binding component 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
C5a anaphylatoxin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
C5a anaphylatoxin receptor activity ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
anaphylatoxin receptor activity IEA
Inferred from Electronic Annotation
more info
 
complement component C5a binding ISO
Inferred from Sequence Orthology
more info
 
complement component C5a receptor activity ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell proliferation in hindbrain ISO
Inferred from Sequence Orthology
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
complement component C5a signaling pathway ISO
Inferred from Sequence Orthology
more info
 
complement receptor mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
C5a anaphylatoxin chemotactic receptor 1
Names
C5a anaphylatoxin chemotactic receptor 1
C5a anaphylatoxin receptor
C5a ligand
C5a-R
complement component 5, receptor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173550.1NP_001167021.1  C5a anaphylatoxin chemotactic receptor 1

    See identical proteins and their annotated locations for NP_001167021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS20846.1
    UniProtKB/Swiss-Prot
    P30993
    Related
    ENSMUSP00000129972, ENSMUST00000168818
    Conserved Domains (1) summary
    pfam00001
    Location:60301
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_007577.4NP_031603.2  C5a anaphylatoxin chemotactic receptor 1

    See identical proteins and their annotated locations for NP_031603.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC156630, BB666123, BC125641
    Consensus CDS
    CCDS20846.1
    UniProtKB/Swiss-Prot
    P30993
    Related
    ENSMUSP00000060003, ENSMUST00000050770
    Conserved Domains (1) summary
    pfam00001
    Location:60301
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    16246743..16259540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    13440651..13453692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)