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Ptprc protein tyrosine phosphatase, receptor type, C [ Mus musculus (house mouse) ]

Gene ID: 19264, updated on 13-Jul-2014
Official Symbol
Ptprcprovided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, Cprovided by MGI
Primary source
MGI:97810
See related
Ensembl:ENSMUSG00000026395; Vega:OTTMUSG00000043098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
loc; B220; Cd45; L-CA; Ly-5; T200; CD45R; Lyt-4
See Ptprc in Epigenomics, MapViewer
Location:
1 E4; 1 60.73 cM
Exon count :
34
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (138062859..138175757, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene microRNA 181b-1 Neighboring gene uncharacterized LOC102637582 Neighboring gene PAP associated domain containing 4 pseudogene Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone marrow development ISO
Inferred from Sequence Orthology
more info
 
cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell adhesion involved in substrate-bound cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of antigen receptor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gamma-delta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hematopoietic stem cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
stem cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell periphery IDA
Inferred from Direct Assay
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
receptor-type tyrosine-protein phosphatase C
lymphocyte antigen 5
leukocyte common antigen
lymphocyte common antigen
NP_001104786.2
NP_001255215.1
NP_035340.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111316.2NP_001104786.2  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

    See proteins identical to NP_001104786.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122903, AC159278, AK054056, BM239381, CA575153, CA577897, CK392851
    Consensus CDS
    CCDS48383.2
    UniProtKB/TrEMBL
    Q8C6Q7
    UniProtKB/TrEMBL
    S4R1S4
    Related
    ENSMUSP00000138350, OTTMUSP00000063320, ENSMUST00000183301, OTTMUST00000113094
    Conserved Domains (5) summary
    pfam12453
    Location:731
    Blast Score: 114
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:211270
    Blast Score: 215
    CD45; Leukocyte receptor CD45
    smart00194
    Location:641900
    Blast Score: 912
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:669900
    Blast Score: 907
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:474553
    Blast Score: 109
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001268286.1NP_001255215.1  receptor-type tyrosine-protein phosphatase C precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks four in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC122903, AK054056, BM239381, CA575153, CA577897
    Consensus CDS
    CCDS59542.1
    UniProtKB/TrEMBL
    Q8C6Q7
    UniProtKB/TrEMBL
    S4R1M0
    Related
    ENSMUSP00000138275, OTTMUSP00000063322, ENSMUST00000182755, OTTMUST00000113096
    Conserved Domains (5) summary
    pfam12453
    Location:731
    Blast Score: 115
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:48107
    Blast Score: 212
    CD45; Leukocyte receptor CD45
    smart00194
    Location:478737
    Blast Score: 899
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:506737
    Blast Score: 896
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:311390
    Blast Score: 112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_011210.4NP_035340.3  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

    See proteins identical to NP_035340.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC122903, AK054056, BM239381, CA575153, CA577897
    Consensus CDS
    CCDS15330.2
    UniProtKB/TrEMBL
    Q8C6Q7
    UniProtKB/TrEMBL
    S4R2V1
    Related
    ENSMUSP00000107667, ENSMUST00000112036
    Conserved Domains (5) summary
    pfam12453
    Location:731
    Blast Score: 115
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:72131
    Blast Score: 213
    CD45; Leukocyte receptor CD45
    smart00194
    Location:502761
    Blast Score: 903
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:530761
    Blast Score: 899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:335414
    Blast Score: 112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    138062859..138175757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529258.1XP_006529321.1  

    See proteins identical to XP_006529321.1

    UniProtKB/TrEMBL
    S4R1S4
    Conserved Domains (5) summary
    pfam12453
    Location:731
    Blast Score: 114
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:211270
    Blast Score: 215
    CD45; Leukocyte receptor CD45
    smart00194
    Location:641900
    Blast Score: 912
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:669900
    Blast Score: 907
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:474553
    Blast Score: 109
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_006529259.1XP_006529322.1  

    See proteins identical to XP_006529322.1

    UniProtKB/TrEMBL
    S4R1S4
    Conserved Domains (5) summary
    pfam12453
    Location:731
    Blast Score: 114
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:211270
    Blast Score: 215
    CD45; Leukocyte receptor CD45
    smart00194
    Location:641900
    Blast Score: 912
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:669900
    Blast Score: 907
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:474553
    Blast Score: 109
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_006529262.1XP_006529325.1  

    Conserved Domains (5) summary
    pfam12453
    Location:731
    Blast Score: 115
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:121180
    Blast Score: 215
    CD45; Leukocyte receptor CD45
    smart00194
    Location:551810
    Blast Score: 908
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:579810
    Blast Score: 903
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:384463
    Blast Score: 111
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_006529260.1XP_006529323.1  

    UniProtKB/TrEMBL
    S4R2V2
    Related
    ENSMUSP00000138801, OTTMUSP00000063323, ENSMUST00000182536, OTTMUST00000113097
    Conserved Domains (5) summary
    pfam12453
    Location:731
    Blast Score: 115
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:168227
    Blast Score: 216
    CD45; Leukocyte receptor CD45
    smart00194
    Location:598857
    Blast Score: 910
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:626857
    Blast Score: 905
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:431510
    Blast Score: 110
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. XM_006529261.1XP_006529324.1  

    Conserved Domains (5) summary
    pfam12453
    Location:731
    Blast Score: 115
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:164223
    Blast Score: 215
    CD45; Leukocyte receptor CD45
    smart00194
    Location:594853
    Blast Score: 910
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:622853
    Blast Score: 905
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:427506
    Blast Score: 111
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. XM_006529257.1XP_006529320.1  

    See proteins identical to XP_006529320.1

    UniProtKB/TrEMBL
    S4R1S4
    Related
    ENSMUSP00000027645, ENSMUST00000027645
    Conserved Domains (5) summary
    pfam12453
    Location:731
    Blast Score: 114
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:211270
    Blast Score: 215
    CD45; Leukocyte receptor CD45
    smart00194
    Location:641900
    Blast Score: 912
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:669900
    Blast Score: 907
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:474553
    Blast Score: 109
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    140702478..140816534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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