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Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [ Mus musculus (house mouse) ]

Gene ID: 20356, updated on 26-Aug-2014
Official Symbol
Sema5aprovided by MGI
Official Full Name
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Aprovided by MGI
Primary source
MGI:107556
See related
Ensembl:ENSMUSG00000022231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
semF; Semaf; AI464145; 5930434A13; 9130201M22Rik
See Sema5a in Epigenomics, MapViewer
Location:
15 B3.1; 15 13.02 cM
Exon count:
24
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 15 NC_000081.6 (32244742..32696341)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102635070 Neighboring gene small nucleolar RNA, C/D box 123 Neighboring gene small nucleolar RNA host gene 18 Neighboring gene uncharacterized LOC102635151 Neighboring gene uncharacterized LOC102635226 Neighboring gene syndecan 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
axon guidance receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
chondroitin sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
receptor activity IEA
Inferred from Electronic Annotation
more info
 
semaphorin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
syndecan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
diencephalon development ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
patterning of blood vessels IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catenin import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extracellular matrix disassembly NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
semaphorin-plexin signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
signal clustering IDA
Inferred from Direct Assay
more info
PubMed 
signal clustering ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
semaphorin-5A
Names
semaphorin-5A
sema F
M-Sema D
semaphorin F
semaphorin-F

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009154.2NP_033180.2  semaphorin-5A precursor

    See proteins identical to NP_033180.2

    Status: VALIDATED

    Source sequence(s)
    AC110236, AK141612, BB643469
    Consensus CDS
    CCDS37055.1
    UniProtKB/TrEMBL
    Q3UPZ0
    Related
    ENSMUSP00000069024, ENSMUST00000067458
    Conserved Domains (4) summary
    cd11263
    Location:50485
    Blast Score: 2551
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    Blast Score: 179
    TSP1; Thrombospondin type 1 repeats
    smart00630
    Location:58460
    Blast Score: 1042
    Sema; semaphorin domain
    pfam01437
    Location:486533
    Blast Score: 133
    PSI; Plexin repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000081.6 

    Range
    32244742..32696341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520044.1XP_006520107.1  

    See proteins identical to XP_006520107.1

    UniProtKB/TrEMBL
    Q3UPZ0
    Conserved Domains (4) summary
    cd11263
    Location:50485
    Blast Score: 2551
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    Blast Score: 179
    TSP1; Thrombospondin type 1 repeats
    smart00630
    Location:58460
    Blast Score: 1042
    Sema; semaphorin domain
    pfam01437
    Location:486533
    Blast Score: 133
    PSI; Plexin repeat
  2. XM_006520043.1XP_006520106.1  

    See proteins identical to XP_006520106.1

    UniProtKB/TrEMBL
    Q3UPZ0
    Conserved Domains (4) summary
    cd11263
    Location:50485
    Blast Score: 2551
    Sema_5A; The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A)
    smart00209
    Location:598651
    Blast Score: 179
    TSP1; Thrombospondin type 1 repeats
    smart00630
    Location:58460
    Blast Score: 1042
    Sema; semaphorin domain
    pfam01437
    Location:486533
    Blast Score: 133
    PSI; Plexin repeat

Alternate Mm_Celera

Genomic

  1. AC_000037.1 

    Range
    32949262..33396657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)