Display Settings:

Format

Send to:

Choose Destination

Cfl1 cofilin 1, non-muscle [ Mus musculus (house mouse) ]

Gene ID: 12631, updated on 13-Sep-2014
Official Symbol
Cfl1provided by MGI
Official Full Name
cofilin 1, non-muscleprovided by MGI
Primary source
MGI:101757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cof; AA959946; n-cofilin
See Cfl1 in Epigenomics, MapViewer
Location:
19 A; 19
Exon count:
4
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 19 NC_000085.6 (5490455..5494031)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Neighboring gene MUS81 endonuclease homolog (yeast) Neighboring gene RIKEN cDNA 1700020D05 gene Neighboring gene sorting nexin 32 Neighboring gene RNA-binding protein 25-like Neighboring gene OVO homolog-like 1 (Drosophila)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell projection organization ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular component movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
PubMed 
neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural fold formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
response to amino acid IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
 
cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cofilin-1
Names
cofilin-1
cofilin, non-muscle isoform

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007687.5NP_031713.1  cofilin-1

    See proteins identical to NP_031713.1

    Status: VALIDATED

    Source sequence(s)
    AI844923, BC058726, CX218255
    UniProtKB/Swiss-Prot
    P18760
    UniProtKB/TrEMBL
    Q544Y7
    Conserved Domains (1) summary
    cd11286
    Location:3153
    Blast Score: 404
    ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000085.6 

    Range
    5490455..5494031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000041.1 

    Range
    5362154..5365730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)