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    Scp2 sterol carrier protein 2, liver [ Mus musculus (house mouse) ]

    Gene ID: 20280, updated on 8-Aug-2016
    Official Symbol
    Scp2provided by MGI
    Official Full Name
    sterol carrier protein 2, liverprovided by MGI
    Primary source
    MGI:MGI:98254
    See related
    Ensembl:ENSMUSG00000028603 Vega:OTTMUSG00000009429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCPX; SCP-2; SCP-X; C76618; C79031; NSL-TP; ns-LTP; AA409774; AA409893
    Orthologs
    Location:
    4 C7; 4 50.2 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (108043830..108144971, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (107716444..107791104, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 1 (glutamate transporter), member 7 Neighboring gene podocan Neighboring gene microRNA 6397 Neighboring gene enoyl Coenzyme A hydratase domain containing 2 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene predicted gene, 40222

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acetyl-CoA C-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    oleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylcholine transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylethanolamine transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    propanoyl-CoA C-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    propionyl-CoA C2-trimethyltridecanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    propionyl-CoA C2-trimethyltridecanoyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sterol transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acyl-CoA metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipid hydroperoxide transport ISO
    Inferred from Sequence Orthology
    more info
     
    lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome TAS
    Traceable Author Statement
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    non-specific lipid-transfer protein
    Names
    SCP-chi
    nonspecific lipid transfer protein
    propanoyl-CoA C-acyltransferase
    sterol carrier protein X
    NP_035457.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011327.4NP_035457.1  non-specific lipid-transfer protein

      See identical proteins and their annotated locations for NP_035457.1

      Status: VALIDATED

      Source sequence(s)
      AK004860, BB774576, CJ238474, DN176201, M91458
      Consensus CDS
      CCDS18446.1
      UniProtKB/Swiss-Prot
      P32020
      Related
      ENSMUSP00000030340, OTTMUSP00000009814, ENSMUST00000030340, OTTMUST00000021471
      Conserved Domains (3) summary
      PRK08256
      Location:12404
      PRK08256; lipid-transfer protein; Provisional
      cd00826
      Location:17403
      nondecarbox_cond_enzymes; nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 ...
      pfam02036
      Location:452538
      SCP2; SCP-2 sterol transfer family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      108043830..108144971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240477.2XP_011238779.1  

      See identical proteins and their annotated locations for XP_011238779.1

      Conserved Domains (3) summary
      PRK08256
      Location:8388
      PRK08256; lipid-transfer protein; Provisional
      cd00826
      Location:8387
      nondecarbox_cond_enzymes; nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 ...
      pfam02036
      Location:436522
      SCP2; SCP-2 sterol transfer family