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Park7 Parkinson disease (autosomal recessive, early onset) 7 [ Mus musculus (house mouse) ]

Gene ID: 57320, updated on 8-Jul-2014
Official Symbol
Park7provided by MGI
Official Full Name
Parkinson disease (autosomal recessive, early onset) 7provided by MGI
Primary source
MGI:2135637
Locus tag
RP23-272N19.5
See related
Ensembl:ENSMUSG00000028964; Vega:OTTMUSG00000010158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dj1; DJ-1
See Park7 in Epigenomics, MapViewer
Location:
4; 4 E1
Exon count :
8
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 4 NC_000070.6 (150897133..150909921, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene uncharacterized LOC102640978 Neighboring gene uncharacterized LOC102631837 Neighboring gene uncharacterized LOC102631764

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
cytokine binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
mRNA binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
peroxiredoxin activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
small protein activating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
small protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine uptake involved in synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ubiquitin-specific protease activity ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of androgen receptor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of oxidative phosphorylation uncoupler activity IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to stress IEA
Inferred from Electronic Annotation
more info
 
single fertilization IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein DJ-1
Names
protein DJ-1
parkinson disease protein 7 homolog
RNA-binding protein regulatory subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020569.3NP_065594.2  protein DJ-1

    See proteins identical to NP_065594.2

    Status: VALIDATED

    Source sequence(s)
    AB015652, CA456587, CD776363
    Consensus CDS
    CCDS18975.1
    UniProtKB/Swiss-Prot
    Q99LX0
    Related
    ENSMUSP00000030805, OTTMUSP00000010787, ENSMUST00000030805, OTTMUST00000023609
    Conserved Domains (2) summary
    cd03135
    Location:6172
    Blast Score: 531
    GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
    TIGR01383
    Location:5184
    Blast Score: 608
    not_thiJ; DJ-1 family protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000070.6 

    Range
    150897133..150909921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539081.1XP_006539144.1  

    Conserved Domains (1) summary
    cl00020
    Location:51116
    Blast Score: 201
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

Reference GRCm38.p2 NOD/MrkTac

Genomic

  1. NT_187025.1 

    Range
    1202157..1214994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000026.1 

    Range
    153174297..153187100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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