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    JUNB jun B proto-oncogene [ Homo sapiens (human) ]

    Gene ID: 3726, updated on 13-Jan-2016
    Official Symbol
    JUNBprovided by HGNC
    Official Full Name
    jun B proto-oncogeneprovided by HGNC
    Primary source
    HGNC:HGNC:6205
    See related
    Ensembl:ENSG00000171223; HPRD:01303; MIM:165161; Vega:OTTHUMG00000180373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AP-1
    Orthologs
    See JUNB in Epigenomics, MapViewer
    Location:
    19p13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (12791496..12793311)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12902310..12904125)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hook microtubule-tethering protein 2 Neighboring gene microRNA 5684 Neighboring gene peroxiredoxin 2 Neighboring gene ribonuclease H2 subunit A

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of jun B proto-oncogene (JUNB) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of JunB is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed
    matrix gag HIV-1 matrix activates monocytes to produce MCP-1, which depends on the binding activity of AP-1 complexes (c-Fos/JunB) in the MCP-1 promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    decidualization IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    labyrinthine layer blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to drug IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to light stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription, DNA-templated TAS
    Traceable Author Statement
    more info
     
    transforming growth factor beta receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    trophectodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromatin TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    transcription factor jun-B
    Names
    activator protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002229.2NP_002220.1  transcription factor jun-B

      See identical proteins and their annotated locations for NP_002220.1

      Status: VALIDATED

      Source sequence(s)
      BC009466
      Consensus CDS
      CCDS12280.1
      UniProtKB/Swiss-Prot
      P17275
      UniProtKB/TrEMBL
      Q5U079
      Related
      ENSP00000303315, OTTHUMP00000264124, ENST00000302754, OTTHUMT00000451015
      Conserved Domains (2) summary
      pfam03957
      Location:5257
      Jun; Jun-like transcription factor
      cd14696
      Location:270329
      bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      12791496..12793311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      12902786..12904601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)