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    LRRK2 leucine-rich repeat kinase 2 [ Homo sapiens (human) ]

    Gene ID: 120892, updated on 24-Aug-2015
    Official Symbol
    LRRK2provided by HGNC
    Official Full Name
    leucine-rich repeat kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:18618
    See related
    Ensembl:ENSG00000188906; MIM:609007; Vega:OTTHUMG00000059742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PARK8; RIPK7; ROCO2; AURA17; DARDARIN
    Summary
    This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
    Orthologs
    See LRRK2 in Epigenomics, MapViewer
    Location:
    12q12
    Exon count:
    54
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (40225011..40369285)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (40618813..40763087)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101930164 Neighboring gene uncharacterized LOC105369734 Neighboring gene uncharacterized LOC105369735 Neighboring gene uncharacterized LOC105369736 Neighboring gene microtubule-associated protein 6 pseudogene Neighboring gene mucin 19, oligomeric Neighboring gene methionyl aminopeptidase 1 pseudogene Neighboring gene contactin 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
    NHGRI GWA Catalog
    Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
    NHGRI GWA Catalog
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    NHGRI GWA Catalog
    Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
    NHGRI GWA Catalog
    Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat LRRK2 kinase inhibition decreases HIV-1 Tat-induced phosphorylation of p38 MAPK and JNK in microglia cells PubMed
    tat HIV-1 Tat induces phosphorylation of LRRK2 in microglia cells PubMed
    tat LRRK2 is involved in HIV-1 Tat-induced cytokine TNF-alpha, IL-6, and MCP-1 expression in microglia cells PubMed
    tat LRRK2 kinase inhibition suppresses HIV-1 Tat-induced upregulation of phosphatidylserine receptor BAI1 in microglia cells PubMed

    Go to the HIV-1, Human Interaction Database

    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
      Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP-dependent protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SNARE binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    actin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    clathrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    glycoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin-1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    GTP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi organization IEA
    Inferred from Electronic Annotation
    more info
     
    MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to dopamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to manganese ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular distribution of mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    locomotory exploration behavior IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hydrogen peroxide-induced cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of late endosome to lysosome transport TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein processing involved in protein targeting to mitochondrion IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of protein targeting to mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of kidney size ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrial fission TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein kinase A signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synaptic vesicle transport TAS
    Traceable Author Statement
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    tangential migration from the subventricular zone to the olfactory bulb IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic side of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inclusion body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    terminal bouton TAS
    Traceable Author Statement
    more info
    PubMed 
    trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    leucine-rich repeat serine/threonine-protein kinase 2
    Names
    augmented in rheumatoid arthritis 17
    NP_940980.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011709.1 RefSeqGene

      Range
      5001..149275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_198578.3NP_940980.3  leucine-rich repeat serine/threonine-protein kinase 2

      See identical proteins and their annotated locations for NP_940980.3

      Status: REVIEWED

      Source sequence(s)
      AK026776, AK122640, AL832453, AY792511, BC117180, BM285390, CN294292
      Consensus CDS
      CCDS31774.1
      UniProtKB/TrEMBL
      Q17RV3
      UniProtKB/Swiss-Prot
      Q5S007
      Related
      ENSP00000298910, OTTHUMP00000179167, ENST00000298910, OTTHUMT00000277179
      Conserved Domains (6) summary
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      smart00220
      Location:18842128
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG4886
      Location:10121286
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:9861208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd14068
      Location:18842135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

      Range
      40225011..40369285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268629.2XP_005268686.1  

      Conserved Domains (6) summary
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      smart00220
      Location:18842128
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG4886
      Location:10121286
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:9861208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd14068
      Location:18842135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]
    2. XM_011537877.1XP_011536179.1  

      Conserved Domains (6) summary
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      smart00220
      Location:18842128
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG4886
      Location:10121286
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:9861208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd14068
      Location:18842135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]
    3. XM_011537878.1XP_011536180.1  

      Conserved Domains (6) summary
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      smart00220
      Location:18842128
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG4886
      Location:10121286
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:9861208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd14068
      Location:18842135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]
    4. XM_011537881.1XP_011536183.1  

      Conserved Domains (5) summary
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      cd00116
      Location:9861208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam12796
      Location:713793
      Ank_2; Ankyrin repeats (3 copies)
      pfam13855
      Location:9841047
      LRR_8; Leucine rich repeat
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]
    5. XM_011537880.1XP_011536182.1  

      Conserved Domains (5) summary
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      cd00116
      Location:9861208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam12796
      Location:713793
      Ank_2; Ankyrin repeats (3 copies)
      pfam13855
      Location:9841047
      LRR_8; Leucine rich repeat
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]
    6. XM_011537882.1XP_011536184.1  

      Conserved Domains (4) summary
      cd00116
      Location:9861208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam12796
      Location:713793
      Ank_2; Ankyrin repeats (3 copies)
      pfam13855
      Location:9841047
      LRR_8; Leucine rich repeat
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]
    7. XM_011537879.1XP_011536181.1  

      Conserved Domains (6) summary
      cd09914
      Location:9331106
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      smart00220
      Location:14831727
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG4886
      Location:611885
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:585807
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd14068
      Location:14831734
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:612635
      LRR_RI; leucine-rich repeat [structural motif]

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      40584126..40728194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)