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    CHKB choline kinase beta [ Homo sapiens (human) ]

    Gene ID: 1120, updated on 8-Aug-2016
    Official Symbol
    CHKBprovided by HGNC
    Official Full Name
    choline kinase betaprovided by HGNC
    Primary source
    HGNC:HGNC:1938
    See related
    Ensembl:ENSG00000100288 HPRD:07631; MIM:612395; Vega:OTTHUMG00000150275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CK; EK; CKB; EKB; CHKL; CHETK; CKEKB; MDCMC
    Summary
    Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009]
    Orthologs
    Location:
    22q13.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 22 NC_000022.11 (50578958..50582999, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (51017387..51021428, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene synaptonemal complex central element protein 3 Neighboring gene uncharacterized LOC107985568 Neighboring gene CHKB-CPT1B readthrough (NMD candidate) Neighboring gene carnitine palmitoyltransferase 1B Neighboring gene CHKB antisense RNA 1 (head to head) Neighboring gene mitogen-activated protein kinase 8 interacting protein 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Readthrough CHKB-CPT1B

    Readthrough gene: CHKB-CPT1B, Included gene: CPT1B

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    choline kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    choline kinase activity TAS
    Traceable Author Statement
    more info
     
    ethanolamine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ethanolamine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylcholine biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylethanolamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylethanolamine biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    choline/ethanolamine kinase
    Names
    choline kinase-like protein
    ethanolamine kinase beta
    NP_005189.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029213.1 RefSeqGene

      Range
      5001..9042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_855

    mRNA and Protein(s)

    1. NM_005198.4NP_005189.2  choline/ethanolamine kinase

      See identical proteins and their annotated locations for NP_005189.2

      Status: REVIEWED

      Source sequence(s)
      AB029886, BE676287, DB106393
      Consensus CDS
      CCDS14099.1
      UniProtKB/Swiss-Prot
      Q9Y259
      UniProtKB/TrEMBL
      A0A024R4X4
      Related
      ENSP00000384400, OTTHUMP00000196839, ENST00000406938, OTTHUMT00000317267
      Conserved Domains (2) summary
      PLN02236
      Location:57388
      PLN02236; choline kinase
      cd05156
      Location:69385
      ChoK_euk; Euykaryotic Choline Kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p7 Primary Assembly

      Range
      50578958..50582999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      50976120..50980161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152253.1: Suppressed sequence

      Description
      NM_152253.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.