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CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 [ Homo sapiens (human) ]

Gene ID: 1572, updated on 7-Dec-2014
Official Symbol
CYP2F1provided by HGNC
Official Full Name
cytochrome P450, family 2, subfamily F, polypeptide 1provided by HGNC
Primary source
HGNC:HGNC:2632
See related
Ensembl:ENSG00000197446; HPRD:00490; MIM:124070; Vega:OTTHUMG00000167412
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2F1; CYP2F
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
See CYP2F1 in Epigenomics, MapViewer
Location:
19q13.2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (41114448..41128376)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41620312..41634286)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily G, polypeptide 2 pseudogene Neighboring gene cytochrome P450, family 2, subfamily A, polypeptide 13 Neighboring gene cytochrome P450, family 2, subfamily T, polypeptide 3, pseudogene Neighboring gene ribosomal protein L36 pseudogene 16

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC126121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
oxygen binding IEA
Inferred from Electronic Annotation
more info
 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
naphthalene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
trichloroethylene metabolic process IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cytochrome P450 2F1
Names
cytochrome P450 2F1
CYPIIF1
microsomal monooxygenase
xenobiotic monooxygenase
flavoprotein-linked monooxygenase
cytochrome P450, subfamily IIF, polypeptide 1
NP_000765.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007930.1 

    Range
    5001..18929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000774.3NP_000765.2  cytochrome P450 2F1 precursor

    See proteins identical to NP_000765.2

    Status: REVIEWED

    Source sequence(s)
    J02906
    Consensus CDS
    CCDS12572.1
    UniProtKB/Swiss-Prot
    P24903
    Related
    ENSP00000333534, OTTHUMP00000235890, ENST00000331105, OTTHUMT00000394527
    Conserved Domains (1) summary
    pfam00067
    Location:31488
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    41114448..41128376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723052.1XP_006723115.1  

    Conserved Domains (1) summary
    pfam00067
    Location:31432
    p450; Cytochrome P450
  2. XM_006723053.1XP_006723116.1  

    Conserved Domains (1) summary
    pfam00067
    Location:31431
    p450; Cytochrome P450

RNA

  1. XR_430191.1 RNA Sequence

  2. XR_430190.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    41620070..41634000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    38052253..38066192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)