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    Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b [ Mus musculus (house mouse) ]

    Gene ID: 21938, updated on 17-Aug-2016
    Official Symbol
    Tnfrsf1bprovided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 1bprovided by MGI
    Primary source
    MGI:MGI:1314883
    See related
    Ensembl:ENSMUSG00000028599 Vega:OTTMUSG00000010013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2
    Orthologs
    Location:
    4 E1; 4 78.17 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (145212368..145246870, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (144802271..144836773, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13D Neighboring gene predicted gene, 36317 Neighboring gene predicted gene, 42343 Neighboring gene predicted gene, 36233 Neighboring gene tumor necrosis factor receptor superfamily, member 8

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor-activated receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    varicosity ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    tumor necrosis factor receptor superfamily member 1B
    Names
    TNF receptor beta chain
    TNF-RII
    TNFR-II
    p75 TNFR
    p80 TNF-alpha receptor
    tumor necrosis factor receptor 2
    tumor necrosis factor receptor type II

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011610.3NP_035740.2  tumor necrosis factor receptor superfamily member 1B precursor

      See identical proteins and their annotated locations for NP_035740.2

      Status: VALIDATED

      Source sequence(s)
      AK140332, BY489212
      Consensus CDS
      CCDS18914.1
      UniProtKB/Swiss-Prot
      P25119
      UniProtKB/TrEMBL
      Q545P4
      Related
      ENSMUSP00000030336, OTTMUSP00000010647, ENSMUST00000030336, OTTMUST00000023284
      Conserved Domains (1) summary
      cd10577
      Location:40203
      TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      145212368..145246870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)