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    PLSCR4 phospholipid scramblase 4 [ Homo sapiens (human) ]

    Gene ID: 57088, updated on 15-Jul-2015
    Official Symbol
    PLSCR4provided by HGNC
    Official Full Name
    phospholipid scramblase 4provided by HGNC
    Primary source
    HGNC:HGNC:16497
    See related
    Ensembl:ENSG00000114698; HPRD:07401; MIM:607612; Vega:OTTHUMG00000159415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRA1
    Orthologs
    See PLSCR4 in Epigenomics, MapViewer
    Location:
    3q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (146192335..146251179, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (145910122..145968966, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 Neighboring gene uncharacterized LOC105374145 Neighboring gene phospholipid scramblase 4 pseudogene Neighboring gene phospholipid scramblase 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CD4 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phospholipid scramblase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phospholipid scrambling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    phospholipid scramblase 4
    Names
    Ca(2+)-dependent phospholipid scramblase 4
    PL scramblase 4
    cell growth inhibiting protein 43

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128304.1NP_001121776.1  phospholipid scramblase 4 isoform a

      See identical proteins and their annotated locations for NP_001121776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AC092982, AF199023, AK128442, AW086426, BC028354, DA185957
      UniProtKB/Swiss-Prot
      Q9NRQ2
      Conserved Domains (1) summary
      pfam03803
      Location:100322
      Scramblase; Scramblase
    2. NM_001128305.1NP_001121777.1  phospholipid scramblase 4 isoform a

      See identical proteins and their annotated locations for NP_001121777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AC092982, AF199023, AK128442, AW086426, BC028354, BI598345, BP201782
      UniProtKB/Swiss-Prot
      Q9NRQ2
      Conserved Domains (1) summary
      pfam03803
      Location:100322
      Scramblase; Scramblase
    3. NM_001128306.1NP_001121778.1  phospholipid scramblase 4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks two alternate exons resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (b) has the same N- and C-termini but is shorter than isoform a.
      Source sequence(s)
      AC092982, AF199023, AK128442, AW086426, BC028354, DA444235
      UniProtKB/TrEMBL
      E9PHR9
      UniProtKB/Swiss-Prot
      Q9NRQ2
      Related
      ENSP00000372561, ENST00000383083
      Conserved Domains (1) summary
      cl02043
      Location:103232
      Tub_2; Tubby C 2
    4. NM_001177304.1NP_001170775.1  phospholipid scramblase 4 isoform c

      See identical proteins and their annotated locations for NP_001170775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and lacks two alternate exons resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
      Source sequence(s)
      AK128442, AW665992, BC028354, BG538024, BU160106, BU567842
      Consensus CDS
      CCDS54651.1
      UniProtKB/Swiss-Prot
      Q9NRQ2
      Related
      ENSP00000415605, OTTHUMP00000215195, ENST00000433593, OTTHUMT00000355173
      Conserved Domains (1) summary
      cl02043
      Location:88217
      Tub_2; Tubby C 2
    5. NM_020353.2NP_065086.2  phospholipid scramblase 4 isoform a

      See identical proteins and their annotated locations for NP_065086.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AC092982, AF199023, AK128442, AW086426, BC028354
      Consensus CDS
      CCDS3133.1
      UniProtKB/Swiss-Prot
      Q9NRQ2
      Related
      ENSP00000347038, OTTHUMP00000215194, ENST00000354952, OTTHUMT00000355172
      Conserved Domains (1) summary
      pfam03803
      Location:100322
      Scramblase; Scramblase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      146192335..146251179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247654.1XP_005247711.1  

      See identical proteins and their annotated locations for XP_005247711.1

      UniProtKB/Swiss-Prot
      Q9NRQ2
      Conserved Domains (1) summary
      pfam03803
      Location:100322
      Scramblase; Scramblase
    2. XM_005247655.1XP_005247712.1  

      See identical proteins and their annotated locations for XP_005247712.1

      UniProtKB/Swiss-Prot
      Q9NRQ2
      Conserved Domains (1) summary
      pfam03803
      Location:100322
      Scramblase; Scramblase
    3. XM_011513031.1XP_011511333.1  

      See identical proteins and their annotated locations for XP_011511333.1

      UniProtKB/Swiss-Prot
      Q9NRQ2
      Conserved Domains (1) summary
      pfam03803
      Location:100322
      Scramblase; Scramblase

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      145873145..145931597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)