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PALLD palladin, cytoskeletal associated protein [ Homo sapiens (human) ]

Gene ID: 23022, updated on 23-Sep-2014
Official Symbol
PALLDprovided by HGNC
Official Full Name
palladin, cytoskeletal associated proteinprovided by HGNC
Primary source
HGNC:HGNC:17068
Locus tag
CGI-151
See related
Ensembl:ENSG00000129116; HPRD:09731; MIM:608092; Vega:OTTHUMG00000161097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYN; PNCA1; CGI151; SIH002; CGI-151
Summary
This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
See PALLD in Epigenomics, MapViewer
Location:
4q32.3
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (168497066..168928457)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (169418215..169849608)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like Neighboring gene basic transcription factor 3-like 4 pseudogene 4 Neighboring gene ribosomal protein L9 pseudogene 16 Neighboring gene uncharacterized LOC101928172 Neighboring gene uncharacterized LOC102723331 Neighboring gene uncharacterized LOC102723317 Neighboring gene uncharacterized LOC102724976 Neighboring gene carbonyl reductase 4 Neighboring gene RNA, Ro-associated Y4 pseudogene 17 Neighboring gene SH3 domain containing ring finger 1 Neighboring gene ribosomal protein L6 pseudogene 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Pancreatic cancer 1
MedGen: C1847351 OMIM: 606856 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
NHGRI GWA Catalog
Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22190, FLJ38193, FLJ39139, FLJ61376, KIAA0992

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
muscle alpha-actinin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Z disc IEA
Inferred from Electronic Annotation
more info
 
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
palladin
Names
palladin
myoneurin
sarcoma antigen NY-SAR-77

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013376.1 

    Range
    5001..436392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166108.1NP_001159580.1  palladin isoform 1

    See proteins identical to NP_001159580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF077041, AF464873, AI418424, AK025843, BC144666
    Consensus CDS
    CCDS54818.1
    UniProtKB/Swiss-Prot
    Q8WX93
    Conserved Domains (3) summary
    cd00096
    Location:458535
    Ig; Immunoglobulin domain
    cd05893
    Location:10441118
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:271361
    I-set; Immunoglobulin I-set domain
  2. NM_001166109.1NP_001159581.1  palladin isoform 3

    See proteins identical to NP_001159581.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream translational start codon, lacks an alternate in-frame exon in the central coding region, and lacks an exon in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC084353, AF077041, AI418424, AK025843, AK095512, DA048169
    Consensus CDS
    CCDS54819.1
    UniProtKB/Swiss-Prot
    Q8WX93
    Conserved Domains (3) summary
    cd00096
    Location:76153
    Ig; Immunoglobulin domain
    cd05893
    Location:645719
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:529619
    I-set; Immunoglobulin I-set domain
  3. NM_001166110.1NP_001159582.1  palladin isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks several exons in the 5' coding region, uses an alternate translational start codon, lacks an alternate in-frame exon in the central coding region, and lacks an exon in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AB023209, AC080188, AF077041, AI418424, DA211938, DB257974
    Consensus CDS
    CCDS54820.1
    UniProtKB/Swiss-Prot
    Q8WX93
    Related
    ENSP00000424016, OTTHUMP00000219715, ENST00000507735, OTTHUMT00000363771
    Conserved Domains (3) summary
    cd00096
    Location:307376
    Ig; Immunoglobulin domain
    cd05893
    Location:540614
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:424514
    I-set; Immunoglobulin I-set domain
  4. NM_016081.3NP_057165.3  palladin isoform 2

    See proteins identical to NP_057165.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC115538, AF464873, AW248292
    Consensus CDS
    CCDS34098.1
    UniProtKB/TrEMBL
    B2RTX2
    UniProtKB/Swiss-Prot
    Q8WX93
    Related
    ENSP00000261509, OTTHUMP00000219711, ENST00000261509, OTTHUMT00000363761
    Conserved Domains (3) summary
    cd00096
    Location:458535
    Ig; Immunoglobulin domain
    cd05893
    Location:10271101
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:271361
    I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    168497066..168928457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262863.2XP_005262920.1  

    Conserved Domains (3) summary
    cd00096
    Location:458535
    Ig; Immunoglobulin domain
    cd05893
    Location:12681342
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:271361
    I-set; Immunoglobulin I-set domain
  2. XM_005262865.2XP_005262922.1  

    Conserved Domains (3) summary
    cd00096
    Location:458535
    Ig; Immunoglobulin domain
    cd05893
    Location:11441218
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:271361
    I-set; Immunoglobulin I-set domain
  3. XM_005262864.2XP_005262921.1  

    Conserved Domains (4) summary
    cd00096
    Location:458535
    Ig; Immunoglobulin domain
    cd05893
    Location:11771251
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:271361
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:9571018
    Ig; Immunoglobulin domain
  4. XM_005262861.2XP_005262918.1  

    Conserved Domains (3) summary
    cd00096
    Location:458535
    Ig; Immunoglobulin domain
    cd05893
    Location:12681342
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:271361
    I-set; Immunoglobulin I-set domain
  5. XM_005262862.2XP_005262919.1  

    See proteins identical to XP_005262919.1

    UniProtKB/Swiss-Prot
    Q8WX93
    Conserved Domains (3) summary
    cd00096
    Location:458535
    Ig; Immunoglobulin domain
    cd05893
    Location:12511325
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:271361
    I-set; Immunoglobulin I-set domain
  6. XM_005262866.1XP_005262923.1  

    Conserved Domains (3) summary
    cd00096
    Location:76153
    Ig; Immunoglobulin domain
    cd05893
    Location:886960
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:770860
    I-set; Immunoglobulin I-set domain

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    165170970..165603126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    169394774..169826047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)