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EFTUD1 elongation factor Tu GTP binding domain containing 1 [ Homo sapiens (human) ]

Gene ID: 79631, updated on 7-Dec-2014
Official Symbol
EFTUD1provided by HGNC
Official Full Name
elongation factor Tu GTP binding domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25789
See related
Ensembl:ENSG00000140598; HPRD:07812; Vega:OTTHUMG00000172573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIA1; FAM42A; HsT19294
See EFTUD1 in Epigenomics, MapViewer
Location:
15q25.2
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (82130220..82262763, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (82422561..82555104, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mex-3 RNA binding family member B Neighboring gene long intergenic non-protein coding RNA 1583 Neighboring gene uncharacterized LOC101929714 Neighboring gene family with sequence similarity 154, member B Neighboring gene ADAMTS7 pseudogene 1

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of elongation factor Tu GTP binding domain containing 1 (EFTUD1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ribosome binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GTP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
mature ribosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational elongation IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
elongation factor Tu GTP-binding domain-containing protein 1
Names
elongation factor Tu GTP-binding domain-containing protein 1
elongation factor-like 1
ribosome assembly 1 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040610.2NP_001035700.1  elongation factor Tu GTP-binding domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC026624, AC026956, BC014628
    Consensus CDS
    CCDS42070.1
    UniProtKB/Swiss-Prot
    Q7Z2Z2
    Related
    ENSP00000352418, OTTHUMP00000248769, ENST00000359445, OTTHUMT00000419253
    Conserved Domains (6) summary
    cd01681
    Location:636935
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd03700
    Location:436550
    eEF2_snRNP_like_II; EF2_snRNP_like_II: this subfamily represents domain II of elongation factor (EF) EF-2 found eukaryotes and archaea and, the C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast ...
    cd04096
    Location:9321010
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:11052
    PTZ00416; elongation factor 2; Provisional
    pfam14492
    Location:565635
    EFG_II; Elongation Factor G, domain II
    cl17170
    Location:20202
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
  2. NM_024580.5NP_078856.4  elongation factor Tu GTP-binding domain-containing protein 1 isoform 1

    See proteins identical to NP_078856.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC026624, AC026956, BC014628
    Consensus CDS
    CCDS42071.1
    UniProtKB/Swiss-Prot
    Q7Z2Z2
    Related
    ENSP00000268206, OTTHUMP00000248768, ENST00000268206, OTTHUMT00000419252
    Conserved Domains (6) summary
    cd01885
    Location:20253
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:687986
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd03700
    Location:487601
    eEF2_snRNP_like_II; EF2_snRNP_like_II: this subfamily represents domain II of elongation factor (EF) EF-2 found eukaryotes and archaea and, the C-terminal portion of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast ...
    cd04096
    Location:9831061
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:11103
    PTZ00416; elongation factor 2; Provisional
    pfam14492
    Location:616686
    EFG_II; Elongation Factor G, domain II

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    82130220..82262763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    82540549..82673133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    59180930..59313486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)