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ME1 malic enzyme 1, NADP(+)-dependent, cytosolic [ Homo sapiens (human) ]

Gene ID: 4199, updated on 13-Sep-2014
Official Symbol
ME1provided by HGNC
Official Full Name
malic enzyme 1, NADP(+)-dependent, cytosolicprovided by HGNC
Primary source
HGNC:HGNC:6983
See related
Ensembl:ENSG00000065833; HPRD:01102; MIM:154250; Vega:OTTHUMG00000015111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MES; HUMNDME
Summary
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
Location:
6q12
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (83210389..83431219, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83920108..84140938, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene dopey family member 1 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene protease, serine, 35 Neighboring gene synaptosomal-associated protein, 91kDa

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Pyruvate metabolism, organism-specific biosystem (from KEGG)
    Pyruvate metabolism, organism-specific biosystem
    Pyruvate metabolism
  • Pyruvate metabolism, conserved biosystem (from KEGG)
    Pyruvate metabolism, conserved biosystem
    Pyruvate metabolism
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding TAS
Traceable Author Statement
more info
PubMed 
NAD binding TAS
Traceable Author Statement
more info
PubMed 
NADP binding TAS
Traceable Author Statement
more info
PubMed 
electron carrier activity TAS
Traceable Author Statement
more info
PubMed 
malate dehydrogenase (decarboxylating) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
malate dehydrogenase (decarboxylating) (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
malic enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NADP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
cellular lipid metabolic process TAS
Traceable Author Statement
more info
 
malate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
response to carbohydrate TAS
Traceable Author Statement
more info
PubMed 
response to hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
NADP-dependent malic enzyme
Names
NADP-dependent malic enzyme
NADP-ME
malate dehydrogenase
malic enzyme 1, soluble
Malic enzyme, cytoplasmic
pyruvic-malic carboxylase
NP_002386.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002395.5NP_002386.1  NADP-dependent malic enzyme

    See proteins identical to NP_002386.1

    Status: REVIEWED

    Source sequence(s)
    AL049699, BC025246, DA520723, KF458214
    Consensus CDS
    CCDS34492.1
    UniProtKB/Swiss-Prot
    P48163
    Related
    ENSP00000358719, OTTHUMP00000016792, ENST00000369705, OTTHUMT00000041350
    Conserved Domains (3) summary
    cd05312
    Location:270547
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:11551
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:79260
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    83210389..83431219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    81148328..81370879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    84017801..84238482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)