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    CYP1A1 cytochrome P450 family 1 subfamily A member 1 [ Homo sapiens (human) ]

    Gene ID: 1543, updated on 22-Jul-2016
    Official Symbol
    CYP1A1provided by HGNC
    Official Full Name
    cytochrome P450 family 1 subfamily A member 1provided by HGNC
    Primary source
    HGNC:HGNC:2595
    See related
    Ensembl:ENSG00000140465 HPRD:00148; MIM:108330; Vega:OTTHUMG00000142812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX
    Summary
    This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
    Orthologs
    Location:
    15q24.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (74719542..74725610, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75011883..75017951, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723750 Neighboring gene CDC like kinase 3 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene cytochrome P450 family 1 subfamily A member 2 Neighboring gene microRNA 4513 Neighboring gene c-src tyrosine kinase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    NHGRI GWA Catalog
    Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
    NHGRI GWA Catalog
    Genome-wide association study identifies eight loci associated with blood pressure.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
    NHGRI GWA Catalog
    Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    demethylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    flavonoid 3'-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    monooxygenase activity TAS
    Traceable Author Statement
    more info
     
    oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity, acting on diphenols and related substances as donors IEA
    Inferred from Electronic Annotation
    more info
     
    oxygen binding TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    steroid hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    vitamin D 24-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    9-cis-retinoic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    amine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    camera-type eye development IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    coumarin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    demethylation IEA
    Inferred from Electronic Annotation
    more info
     
    dibenzo-p-dioxin catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    drug metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryo development ending in birth or egg hatching IEA
    Inferred from Electronic Annotation
    more info
     
    epoxygenase P450 pathway TAS
    Traceable Author Statement
    more info
     
    ethylene metabolic process TAS
    Traceable Author Statement
    more info
     
    flavonoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    hydrogen peroxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    insecticide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    maternal process involved in parturition IEA
    Inferred from Electronic Annotation
    more info
     
    omega-hydroxylase P450 pathway TAS
    Traceable Author Statement
    more info
     
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    porphyrin-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to food IEA
    Inferred from Electronic Annotation
    more info
     
    response to herbicide IEA
    Inferred from Electronic Annotation
    more info
     
    response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
     
    response to iron(III) ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to nematode IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    vitamin D metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    organelle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cytochrome P450 1A1
    Names
    aryl hydrocarbon hydroxylase
    cytochrome P1-450, dioxin-inducible
    cytochrome P450 form 6
    cytochrome P450, family 1, subfamily A, polypeptide 1
    cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
    cytochrome P450-C
    cytochrome P450-P1
    flavoprotein-linked monooxygenase
    xenobiotic monooxygenase
    NP_000490.1
    NP_001306145.1
    NP_001306146.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008431.2 RefSeqGene

      Range
      2001..8069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000499.4NP_000490.1  cytochrome P450 1A1 isoform 1

      See identical proteins and their annotated locations for NP_000490.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AK313880, BC023019, DA693879
      Consensus CDS
      CCDS10268.1
      UniProtKB/Swiss-Prot
      P04798
      UniProtKB/TrEMBL
      A0N0X8
      Related
      ENSP00000378488, ENST00000395048
      Conserved Domains (1) summary
      pfam00067
      Location:40493
      p450; Cytochrome P450
    2. NM_001319216.1NP_001306145.1  cytochrome P450 1A1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame coding exon, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      BC023019, DA693879
      UniProtKB/Swiss-Prot
      P04798
      UniProtKB/TrEMBL
      E7EMT5
      Related
      ENSP00000378489, OTTHUMP00000249685, ENST00000395049, OTTHUMT00000421250
      Conserved Domains (1) summary
      pfam00067
      Location:40464
      p450; Cytochrome P450
    3. NM_001319217.1NP_001306146.1  cytochrome P450 1A1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      BC023019, DA693879
      UniProtKB/Swiss-Prot
      P04798
      UniProtKB/TrEMBL
      A0N0X8
      Related
      ENSP00000369050, OTTHUMP00000183469, ENST00000379727, OTTHUMT00000286396
      Conserved Domains (1) summary
      pfam00067
      Location:40493
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      74719542..74725610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021953.1XP_016877442.1  

      Related
      ENSP00000479744, ENST00000612821

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      75130208..75136276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)