Display Settings:

Format

Send to:

Choose Destination

ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 [ Homo sapiens (human) ]

Gene ID: 9639, updated on 19-Jul-2014
Official Symbol
ARHGEF10provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 10provided by HGNC
Primary source
HGNC:14103
See related
Ensembl:ENSG00000104728; HPRD:09735; MIM:608136; Vega:OTTHUMG00000163626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GEF10
Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008]
See ARHGEF10 in Epigenomics, MapViewer
Location:
8p23
Exon count:
30
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (1823983..1958641)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (1772149..1906807)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 3674 Neighboring gene microRNA 596 Neighboring gene uncharacterized LOC100131395 Neighboring gene uncharacterized LOC101928058 Neighboring gene kelch repeat and BTB (POZ) domain containing 11 Neighboring gene myomesin 2 Neighboring gene microRNA 7160

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Slowed nerve conduction velocity, autosomal dominant
MedGen: C1842357 OMIM: 608236 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study of brain lesion distribution in multiple sclerosis.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC131664, DKFZp686H0726

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Rho GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Rho GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle assembly involved in mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
rho guanine nucleotide exchange factor 10
Names
rho guanine nucleotide exchange factor 10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008480.1 

    Range
    5001..139659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_234

mRNA and Protein(s)

  1. NM_014629.2NP_055444.2  rho guanine nucleotide exchange factor 10

    See proteins identical to NP_055444.2

    Status: REVIEWED

    Source sequence(s)
    AA758332, AB002292, AI348138, CN307765
    Consensus CDS
    CCDS34794.1
    UniProtKB/Swiss-Prot
    O15013
    Related
    ENSP00000340297, OTTHUMP00000224478, ENST00000349830, OTTHUMT00000374589
    Conserved Domains (2) summary
    cd00160
    Location:397581
    Blast Score: 443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:614678
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_187576.1 

    Range
    7359..142017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725111.1XP_006725174.1  

    See proteins identical to XP_006725174.1

    UniProtKB/Swiss-Prot
    O15013
    Conserved Domains (2) summary
    cd00160
    Location:359543
    Blast Score: 447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:576640
    Blast Score: 95
    PH-like; Pleckstrin homology-like domain
  2. XM_006725107.1XP_006725170.1  

    See proteins identical to XP_006725170.1

    Conserved Domains (2) summary
    cd00160
    Location:398582
    Blast Score: 443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:615679
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  3. XM_006725106.1XP_006725169.1  

    See proteins identical to XP_006725169.1

    UniProtKB/Swiss-Prot
    O15013
    Conserved Domains (2) summary
    cd00160
    Location:422605
    Blast Score: 457
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:638702
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  4. XM_006725104.1XP_006725167.1  

    See proteins identical to XP_006725167.1

    UniProtKB/Swiss-Prot
    O15013
    Conserved Domains (2) summary
    cd00160
    Location:422606
    Blast Score: 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:639703
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  5. XM_006725110.1XP_006725173.1  

    See proteins identical to XP_006725173.1

    Conserved Domains (2) summary
    cd00160
    Location:422606
    Blast Score: 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:639703
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  6. XM_006725108.1XP_006725171.1  

    See proteins identical to XP_006725171.1

    Conserved Domains (2) summary
    cd00160
    Location:383567
    Blast Score: 448
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:600664
    Blast Score: 95
    PH-like; Pleckstrin homology-like domain
  7. XM_006725105.1XP_006725168.1  

    See proteins identical to XP_006725168.1

    Conserved Domains (2) summary
    cd00160
    Location:421605
    Blast Score: 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:638702
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  8. XM_006725109.1XP_006725172.1  

    See proteins identical to XP_006725172.1

    Conserved Domains (2) summary
    cd00160
    Location:382566
    Blast Score: 448
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:599663
    Blast Score: 95
    PH-like; Pleckstrin homology-like domain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    1823983..1958641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266042.1XP_005266099.1  

    See proteins identical to XP_005266099.1

    UniProtKB/Swiss-Prot
    O15013
    Related
    ENSP00000427909, OTTHUMP00000224479, ENST00000520359, OTTHUMT00000374590
    Conserved Domains (2) summary
    cd00160
    Location:359543
    Blast Score: 447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:576640
    Blast Score: 95
    PH-like; Pleckstrin homology-like domain
  2. XM_005266041.1XP_005266098.1  

    See proteins identical to XP_005266098.1

    Conserved Domains (2) summary
    cd00160
    Location:398582
    Blast Score: 443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:615679
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  3. XM_005266040.2XP_005266097.1  

    See proteins identical to XP_005266097.1

    UniProtKB/Swiss-Prot
    O15013
    Related
    ENSP00000431012, OTTHUMP00000224480
    Conserved Domains (2) summary
    cd00160
    Location:422605
    Blast Score: 457
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:638702
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  4. XM_006716238.1XP_006716301.1  

    See proteins identical to XP_006716301.1

    UniProtKB/Swiss-Prot
    O15013
    Conserved Domains (2) summary
    cd00160
    Location:422606
    Blast Score: 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:639703
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  5. XM_006716241.1XP_006716304.1  

    See proteins identical to XP_006716304.1

    Conserved Domains (2) summary
    cd00160
    Location:422606
    Blast Score: 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:639703
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  6. XM_006716239.1XP_006716302.1  

    See proteins identical to XP_006716302.1

    Conserved Domains (2) summary
    cd00160
    Location:383567
    Blast Score: 448
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:600664
    Blast Score: 95
    PH-like; Pleckstrin homology-like domain
  7. XM_005266039.1XP_005266096.1  

    See proteins identical to XP_005266096.1

    Related
    ENSP00000381571, ENST00000398564
    Conserved Domains (2) summary
    cd00160
    Location:421605
    Blast Score: 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:638702
    Blast Score: 94
    PH-like; Pleckstrin homology-like domain
  8. XM_006716240.1XP_006716303.1  

    See proteins identical to XP_006716303.1

    Conserved Domains (2) summary
    cd00160
    Location:382566
    Blast Score: 448
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:599663
    Blast Score: 95
    PH-like; Pleckstrin homology-like domain

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    1586197..1723095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    1772111..1906332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)