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Pink1 PTEN induced putative kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 68943, updated on 21-Feb-2015
Official Symbol
Pink1provided by MGI
Official Full Name
PTEN induced putative kinase 1provided by MGI
Primary source
MGI:MGI:1916193
See related
Ensembl:ENSMUSG00000028756; Vega:OTTMUSG00000009975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BRPK; AU042772; AW557854; mFLJ00387; 1190006F07Rik
Orthologs
See Pink1 in MapViewer
Location:
4; 4 D3
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (138313409..138326296, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene kinesin family member 17 Neighboring gene dolichyl-di-phosphooligosaccharide-protein glycotransferase Neighboring gene microRNA 7019 Neighboring gene cytidine deaminase Neighboring gene family with sequence similarity 43, member B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
C3HC4-type RING finger domain binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
mitochondrion degradation IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrion degradation ISO
Inferred from Sequence Orthology
more info
 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagic vacuole assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitochondrion degradation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative stress-induced cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catecholamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cristae formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
respiratory electron transport chain IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with TORC2 complex ISO
Inferred from Sequence Orthology
more info
 
astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cell body ISO
Inferred from Sequence Orthology
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
serine/threonine-protein kinase PINK1, mitochondrial
Names
serine/threonine-protein kinase PINK1, mitochondrial
PTEN-induced putative kinase protein 1
NP_081156.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026880.2NP_081156.2  serine/threonine-protein kinase PINK1, mitochondrial precursor

    See proteins identical to NP_081156.2

    Status: VALIDATED

    Source sequence(s)
    BC067066, CX238874
    Consensus CDS
    CCDS18825.1
    UniProtKB/Swiss-Prot
    Q99MQ3
    Related
    ENSMUSP00000030536, OTTMUSP00000010580, ENSMUST00000030536, OTTMUST00000023184
    Conserved Domains (1) summary
    cd14018
    Location:162511
    STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    138313409..138326296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    140093554..140110379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)