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Me1 malic enzyme 1, NADP(+)-dependent, cytosolic [ Mus musculus (house mouse) ]

Gene ID: 17436, updated on 4-May-2015
Official Symbol
Me1provided by MGI
Official Full Name
malic enzyme 1, NADP(+)-dependent, cytosolicprovided by MGI
Primary source
MGI:MGI:97043
See related
Ensembl:ENSMUSG00000032418; Vega:OTTMUSG00000045046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mod1; Mdh-1; Mod-1; D9Ertd267e
Orthologs
See Me1 in MapViewer
Location:
9 E3.1; 9 46.58 cM
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (86581363..86695914, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (86474970..86589947, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene dopey family member 1 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene RIKEN cDNA A330041J22 gene Neighboring gene protease, serine 35 Neighboring gene synaptosomal-associated protein 91

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC91072

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
NADP binding ISO
Inferred from Sequence Orthology
more info
 
malate dehydrogenase (decarboxylating) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
malate dehydrogenase (decarboxylating) (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
malate dehydrogenase (decarboxylating) (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
malic enzyme activity ISO
Inferred from Sequence Orthology
more info
 
malic enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
malate metabolic process ISO
Inferred from Sequence Orthology
more info
 
malate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
oxidation-reduction process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tetramerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
response to hormone ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
NADP-dependent malic enzyme
Names
NADP-dependent malic enzyme
NADP-ME
malic enzyme, supernatant
NP_001185862.1
NP_032641.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198933.1NP_001185862.1  NADP-dependent malic enzyme isoform 2

    See identical proteins and their annotated locations for NP_001185862.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon at its 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK077968, AK163403, AV363687
    UniProtKB/Swiss-Prot
    P06801
    UniProtKB/TrEMBL
    Q3TQP6
    Related
    ENSMUSP00000140887, OTTMUSP00000066083, ENSMUST00000185374, OTTMUST00000118381
    Conserved Domains (3) summary
    cd05312
    Location:250527
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:7531
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:59240
    malic; Malic enzyme, N-terminal domain
  2. NM_008615.2NP_032641.2  NADP-dependent malic enzyme isoform 1

    See identical proteins and their annotated locations for NP_032641.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK077968, AV363687, CJ070715
    Consensus CDS
    CCDS23383.1
    UniProtKB/Swiss-Prot
    P06801
    Related
    ENSMUSP00000034989, OTTMUSP00000066082, ENSMUST00000034989, OTTMUST00000118380
    Conserved Domains (3) summary
    cd05312
    Location:270547
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:2551
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:79260
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    86581363..86695914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242666.1XP_011240968.1  

    Conserved Domains (3) summary
    cd05312
    Location:195472
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    COG0281
    Location:5474
    SfcA; Malic enzyme [Energy production and conversion]
    pfam00390
    Location:4185
    malic; Malic enzyme, N-terminal domain

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    83658088..83772920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)