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    RPL8 ribosomal protein L8 [ Homo sapiens (human) ]

    Gene ID: 6132, updated on 27-Jun-2015
    Official Symbol
    RPL8provided by HGNC
    Official Full Name
    ribosomal protein L8provided by HGNC
    Primary source
    HGNC:HGNC:10368
    See related
    Ensembl:ENSG00000161016; HPRD:16044; MIM:604177; Vega:OTTHUMG00000165249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L8
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Orthologs
    See RPL8 in Epigenomics, MapViewer
    Location:
    8q24.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (144789767..144792420, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146015152..146017805, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375805 Neighboring gene zinc finger protein 34 Neighboring gene microRNA 6850 Neighboring gene zinc finger protein 517 Neighboring gene zinc finger protein 7 Neighboring gene COMM domain containing 5

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    • Homologs of the RPL8 gene: The RPL8 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
    • Orthologs from Annotation Pipeline: 135 organisms have orthologs with human gene RPL8
    • Map Viewer (Mouse)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    SRP-dependent cotranslational protein targeting to membrane TAS
    Traceable Author Statement
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
    Traceable Author Statement
    more info
     
    translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    translation TAS
    Traceable Author Statement
    more info
     
    translational elongation TAS
    Traceable Author Statement
    more info
     
    translational initiation TAS
    Traceable Author Statement
    more info
     
    translational termination TAS
    Traceable Author Statement
    more info
     
    viral life cycle TAS
    Traceable Author Statement
    more info
     
    viral process TAS
    Traceable Author Statement
    more info
     
    viral transcription TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    60S ribosomal protein L8
    Names
    60S ribosomal protein L8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000973.3NP_000964.1  60S ribosomal protein L8

      See identical proteins and their annotated locations for NP_000964.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript. It has a different 5' UTR than variant 2. These variants encode identical proteins.
      Source sequence(s)
      BC093064
      Consensus CDS
      CCDS6433.1
      UniProtKB/Swiss-Prot
      P62917
      Related
      ENSP00000262584, OTTHUMP00000229067, ENST00000262584, OTTHUMT00000382948
      Conserved Domains (3) summary
      PTZ00180
      Location:1254
      PTZ00180; 60S ribosomal protein L8; Provisional
      pfam03947
      Location:96230
      Ribosomal_L2_C; Ribosomal Proteins L2, C-terminal domain
      pfam00181
      Location:1190
      Ribosomal_L2; Ribosomal Proteins L2, RNA binding domain
    2. NM_033301.1NP_150644.1  60S ribosomal protein L8

      See identical proteins and their annotated locations for NP_150644.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a different 5' UTR than variant 1. These variants encode identical proteins.
      Source sequence(s)
      BC012197
      Consensus CDS
      CCDS6433.1
      UniProtKB/Swiss-Prot
      P62917
      Related
      ENSP00000378378, OTTHUMP00000229065, ENST00000394920, OTTHUMT00000382946
      Conserved Domains (3) summary
      PTZ00180
      Location:1254
      PTZ00180; 60S ribosomal protein L8; Provisional
      pfam03947
      Location:96230
      Ribosomal_L2_C; Ribosomal Proteins L2, C-terminal domain
      pfam00181
      Location:1190
      Ribosomal_L2; Ribosomal Proteins L2, RNA binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

      Range
      144789767..144792420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517210.1XP_011515512.1  

      See identical proteins and their annotated locations for XP_011515512.1

      Conserved Domains (3) summary
      PTZ00180
      Location:1254
      PTZ00180; 60S ribosomal protein L8; Provisional
      pfam03947
      Location:96230
      Ribosomal_L2_C; Ribosomal Proteins L2, C-terminal domain
      pfam00181
      Location:1190
      Ribosomal_L2; Ribosomal Proteins L2, RNA binding domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      146053730..146056381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)