Display Settings:

Format

Send to:

Choose Destination

TSPO translocator protein (18kDa) [ Homo sapiens (human) ]

Gene ID: 706, updated on 26-Jun-2015
Official Symbol
TSPOprovided by HGNC
Official Full Name
translocator protein (18kDa)provided by HGNC
Primary source
HGNC:HGNC:1158
See related
Ensembl:ENSG00000100300; HPRD:15913; MIM:109610; Vega:OTTHUMG00000150573
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18
Summary
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
Orthologs
See TSPO in Epigenomics, MapViewer
Location:
22q13.31
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (43151514..43163242)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (43547520..43559248)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene BCL2-interacting killer (apoptosis-inducing) Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) Neighboring gene tubulin tyrosine ligase-like family member 12 Neighboring gene uncharacterized LOC105373052 Neighboring gene signal peptide, CUB domain, EGF-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of TSPO by shRNA enhances HIV-1 replication in nonpermissive NKR cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment with TSPO antagonists or knockdown of TSPO by shRNA activate HIV-1 replication in nonpermissive NKR cells by restoring HIV-1 gp120/gp41 biogenesis PubMed
Envelope surface glycoprotein gp160, precursor env TSPO inhibits HIV-1 Env expression in 293T cells in a dose-dependent manner PubMed
Envelope transmembrane glycoprotein gp41 env Treatment with TSPO antagonists or knockdown of TSPO by shRNA activate HIV-1 replication in nonpermissive NKR cells by restoring HIV-1 gp120/gp41 biogenesis PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
androgen binding IEA
Inferred from Electronic Annotation
more info
 
benzodiazepine receptor activity IEA
Inferred from Electronic Annotation
more info
 
cholesterol binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adrenal gland development IEA
Inferred from Electronic Annotation
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
anion transport TAS
Traceable Author Statement
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
behavioral response to pain IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular hypotonic response IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
chloride transport IEA
Inferred from Electronic Annotation
more info
 
contact inhibition IEA
Inferred from Electronic Annotation
more info
 
glial cell migration IEA
Inferred from Electronic Annotation
more info
 
heme biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system axon regeneration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
PubMed 
regulation of cholesterol transport TAS
Traceable Author Statement
more info
PubMed 
regulation of steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to manganese ion IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
response to vitamin B1 IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
steroid metabolic process TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
translocator protein
Names
translocator protein
benzodiazepine peripheral binding site
mitochondrial benzodiazepine receptor
peripheral-type benzodiazepine receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000714.5NP_000705.2  translocator protein

    See identical proteins and their annotated locations for NP_000705.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PBR) consists of four exons and encodes the protein PBR.
    Source sequence(s)
    AF075589, BC001110, BG752086, BP420304
    Consensus CDS
    CCDS33661.1
    UniProtKB/TrEMBL
    O76068
    UniProtKB/Swiss-Prot
    P30536
    Related
    ENSP00000338004, OTTHUMP00000197857, ENST00000337554, OTTHUMT00000318951
    Conserved Domains (1) summary
    pfam03073
    Location:9156
    TspO_MBR; TspO/MBR family
  2. NM_001256530.1NP_001243459.1  translocator protein

    See identical proteins and their annotated locations for NP_001243459.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant PBR. Variants PBR, 3 and 4 encode the same protein.
    Source sequence(s)
    AF075590, BC001110, BG750685
    Consensus CDS
    CCDS33661.1
    UniProtKB/TrEMBL
    O76068
    UniProtKB/Swiss-Prot
    P30536
    Related
    ENSP00000379563, ENST00000396265
    Conserved Domains (1) summary
    pfam03073
    Location:9156
    TspO_MBR; TspO/MBR family
  3. NM_001256531.1NP_001243460.1  translocator protein

    See identical proteins and their annotated locations for NP_001243460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant PBR. Variants PBR, 3 and 4 encode the same protein.
    Source sequence(s)
    AF075590, BC001110, BG749252
    Consensus CDS
    CCDS33661.1
    UniProtKB/TrEMBL
    O76068
    UniProtKB/Swiss-Prot
    P30536
    Related
    ENSP00000328973, OTTHUMP00000198250, ENST00000329563, OTTHUMT00000319618
    Conserved Domains (1) summary
    pfam03073
    Location:9156
    TspO_MBR; TspO/MBR family

RNA

  1. NR_046308.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (PBR-S) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the longest available open reading frame is found in a different frame, compared to variant PBR, and there is no experimental support for the existence of the predicted protein. This transcript has been described in PMID:8307574.
    Source sequence(s)
    AF075589, BC001110, BG752086, BP420304, L21950

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    43151514..43163242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    43507104..43518509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007311.3: Suppressed sequence

    Description
    NM_007311.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.