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cindr CIN85 and CD2AP related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43654, updated on 4-Apr-2024

Summary

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Official Symbol
cindrprovided by FlyBase
Official Full Name
CIN85 and CD2AP relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0027598
Locus tag
Dmel_CG31012
See related
AllianceGenome:FB:FBgn0027598
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH03163; CD2AP; CG11316; CG1408; CG31012; Cindir; Cindr; Dmel\CG31012
Summary
Enables GTPase activating protein binding activity; SH3 domain binding activity; and cell adhesion molecule binding activity. Involved in several processes, including adherens junction assembly; border follicle cell migration; and positive regulation of receptor-mediated endocytosis. Located in several cellular components, including cleavage furrow; fusome; and midbody. Is active in apical cortex. Is expressed in several structures, including adult cerebral ganglion; eye; gonad; imaginal disc; and photoreceptor cell. Used to study nephrotic syndrome and tauopathy. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 3; and immunodeficiency 61. Orthologous to several human genes including SH3KBP1 (SH3 domain containing kinase binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
100A6-100A6; 3-101 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30808617..30827005)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26634339..26652727)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mir-1013 stem loop Neighboring gene warts Neighboring gene dj-1beta Neighboring gene uncharacterized protein Neighboring gene tailless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Using Genetic and Species Diversity to Tackle Kidney Disease. Garrett MR, et al. Trends Genet, 2020 Jul. PMID 32362446, Free PMC Article
  2. Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline. Eikenes ÅH, et al. Dev Biol, 2013 May 1. PMID 23499247
  3. Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex. Tossidou I, et al. J Am Soc Nephrol, 2019 Jul. PMID 31235616, Free PMC Article
  4. Using Drosophila nephrocytes in genetic kidney disease. Helmstädter M, et al. Cell Tissue Res, 2017 Jul. PMID 28401308
  5. Drosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation. Safi F, et al. Mol Biol Cell, 2016 Mar 15. PMID 26823013, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a genetic modifier screen that identified E3 ligases that modified the rough-eye phenotype generated by expression of cindr RNA interference transgenes during Drosophila eye development.
    Title: A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning.
  2. Silencing Cindr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span, as well as collapse of nephrocyte lacunar channels and effacement of nephrocyte slit diaphragms. These phenotypes could be rescued by expression of a wild-type human CD2AP gene, but not a mutant allele derived from a patient with CD2AP-associated NS.
    Title: A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome.
  3. correct Cindr-dJNK stoichiometry is essential to maintain epithelial integrity and disturbing this balance may contribute to the pathogenesis of disease states, including cancer
    Title: The adaptor protein Cindr regulates JNK activity to maintain epithelial sheet integrity.
  4. Cindr co-localizes with Anillin at mitotic and meiotic ring canals and is recruited to the contractile ring by Anillin during male germ cell meiotic cytokinesis.
    Title: Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline.
  5. Cindr recapitulates both proposed functions of its mammalian orthologs Cd2ap and Cin85: targeting the IgCAMs Rst and Hbs for endocytosis and stabilizing these heterophilic IgCAM complexes.
    Title: Interactions between Drosophila IgCAM adhesion receptors and cindr, the Cd2ap/Cin85 ortholog.
  6. Cindr-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia. Cindr forms a physical complex with Asap
    Title: Role for a Cindr-Arf6 axis in patterning emerging epithelia.
  7. Data suggest that Cindr and Anillin cooperate to promote intercellular bridge stability during incomplete cytokinesis in Drosophila melanogaster.
    Title: Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 30818868-30820372 mobile_element_type = transposon:1360{}1463

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SH3 domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adherens junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intercellular bridge organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor-mediated endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fusome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CIN85 and CD2AP related
Names
CD2AP and CIN85 orthologue
CG31012-PA
CG31012-PB
CG31012-PC
CG31012-PD
CG31012-PE
CG31012-PF
CG31012-PG
CG31012-PH
CG31012-PI
CG31012-PJ
CIN85 and CD2AP orthologue
cindr
cindr-PA
cindr-PB
cindr-PC
cindr-PD
cindr-PE
cindr-PF
cindr-PG
cindr-PH
cindr-PI
cindr-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30808617..30827005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276200.1 → NP_001263129.1  CIN85 and CD2AP related, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263129.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI34, Q7YU85
    Conserved Domains (3) summary
    cd11873
    Location:6 → 60
    SH3_CD2AP-like_1; First Src Homology 3 domain (SH3A) of CD2-associated protein and similar proteins
    cd11874
    Location:97 → 149
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd11875
    Location:258 → 310
    SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins

  2. NM_001276195.1 → NP_001263124.1  CIN85 and CD2AP related, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263124.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI32, Q7YU85
    Conserved Domains (3) summary
    cd11874
    Location:63 → 115
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd11875
    Location:224 → 276
    SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins
    cl17036
    Location:1 → 26
    SH3; Src Homology 3 domain superfamily

  3. NM_170526.3 → NP_733405.2  CIN85 and CD2AP related, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733405.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU85, Q9VA36
    Related
    FBpp0085066
    Conserved Domains (3) summary
    cd11873
    Location:6 → 60
    SH3_CD2AP-like_1; First Src Homology 3 domain (SH3A) of CD2-associated protein and similar proteins
    cd11874
    Location:97 → 149
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd11875
    Location:258 → 310
    SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins

  4. NM_001276197.1 → NP_001263126.1  CIN85 and CD2AP related, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263126.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHG1
    Conserved Domains (1) summary
    cd11875
    Location:11 → 63
    SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins

  5. NM_001276196.1 → NP_001263125.1  CIN85 and CD2AP related, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263125.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHJ8
    Conserved Domains (1) summary
    cd11875
    Location:11 → 63
    SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins

  6. NM_170528.3 → NP_733407.2  CIN85 and CD2AP related, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733407.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PF3
    Related
    FBpp0085067
    Conserved Domains (1) summary
    cd11875
    Location:11 → 63
    SH3_CD2AP-like_3; Third Src Homology 3 domain (SH3C) of CD2-associated protein and similar proteins

  7. NM_170527.3 → NP_733406.1  CIN85 and CD2AP related, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733406.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VA35
    Related
    FBpp0085069

  8. NM_143570.4 → NP_651827.1  CIN85 and CD2AP related, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9Y154
    Related
    FBpp0085068

  9. NM_001276198.1 → NP_001263127.1  CIN85 and CD2AP related, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263127.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9Y154

  10. NM_001276199.1 → NP_001263128.1  CIN85 and CD2AP related, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263128.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9Y154
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHG1 A0A0B4KHG1
A0A0B4KHJ8 A0A0B4KHJ8
A0A0B4KI32 A0A0B4KI32
A0A0B4KI34 A0A0B4KI34
Q7YU85 Q7YU85
Q86PF3 Q86PF3
Q9VA35 Q9VA35
Q9VA36 Q9VA36
Q9Y154 Q9Y154

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