eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: eif2ak3provided by Xenbase
Official Full Name: eukaryotic translation initiation factor 2 alpha kinase 3provided by Xenbase
Primary source: Xenbase:XB-GENE-989849
See related: Ensembl:ENSXETG00000001926
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: PERK
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (18066973..18099673)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (15536179..15554517, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to chemical stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of nitrogen compound metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of primary metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: eukaryotic translation initiation factor 2-alpha kinase 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

18066973..18099673

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031895293.1 → XP_031751153.1 eukaryotic translation initiation factor 2-alpha kinase 3 isoform X3

UniProtKB/TrEMBL

A0A6I8QSL9, F6XRP4

Related

ENSXETP00000071407.2, ENSXETT00000080060.2

Conserved Domains (3) summary

cd09768
Location:97 → 412

Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3

cd14048
Location:579 → 1063

STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase

cl21453
Location:873 → 946

PKc_like; Protein Kinases, catalytic domain
XM_031895291.1 → XP_031751151.1 eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1

UniProtKB/TrEMBL

A0A6I8RUC9, F6XRP4

Related

ENSXETP00000086339.2, ENSXETT00000067580.2

Conserved Domains (3) summary

cd09768
Location:97 → 412

Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3

cd14048
Location:615 → 1099

STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase

cl21453
Location:909 → 982

PKc_like; Protein Kinases, catalytic domain
XM_031895292.1 → XP_031751152.1 eukaryotic translation initiation factor 2-alpha kinase 3 isoform X2

UniProtKB/TrEMBL

A0A8J1IZX1, F6XRP4

Related

ENSXETP00000004094.5, ENSXETT00000004094.5

Conserved Domains (3) summary

cd09768
Location:96 → 411

Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3

cd14048
Location:614 → 1098

STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase

cl21453
Location:908 → 981

PKc_like; Protein Kinases, catalytic domain