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    CD44 CD44 molecule [ Equus caballus (horse) ]

    Gene ID: 100034221, updated on 8-Mar-2024

    Summary

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    Official Symbol
    CD44provided by VGNC
    Official Full Name
    CD44 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:59434
    See related
    Ensembl:ENSECAG00000010267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 12 NC_009155.3 (1842209..1929249)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 12 NC_009155.2 (1832512..1918248)

    Chromosome 12 - NC_009155.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102149165 Neighboring gene uncharacterized LOC102149213 Neighboring gene solute carrier family 1 member 2 Neighboring gene peptidase domain containing associated with muscle regeneration 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immunolocalization of the hyaluronan receptor CD44 in the reproductive tract of the mare. Rodriguez Hurtado I, et al. Theriogenology, 2011 Jan 15. PMID 20932561
    2. Molecular cloning of equine CD44 cDNA by a COS cell expression system. Tavernor AS, et al. Immunogenetics, 1993. PMID 8436424
    3. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An important role for the Hyaluronan-CD44 signaling pathway in reproductive function and inflammation.
      Title: Immunolocalization of the hyaluronan receptor CD44 in the reproductive tract of the mare.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of macrophage migration inhibitory factor receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CD44 antigen
    Names
    CD44 antigen-like protein
    CD44 molecule (Indian blood group)
    ECMR-III
    GP90 lymphocyte homing/adhesion receptor
    HUTCH-I
    PGP-1
    PGP-I
    extracellular matrix receptor III
    hermes antigen
    hyaluronate receptor
    lymphocyte surface antigen precursor CD44
    phagocytic glycoprotein 1
    phagocytic glycoprotein I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085435.2 → NP_001078904.2  CD44 antigen precursor

      See identical proteins and their annotated locations for NP_001078904.2

      Status: VALIDATED

      Source sequence(s)
      BM734801, CD465192, CD466893, CD469117, CD470029, CD472195
      UniProtKB/Swiss-Prot
      Q05078
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009155.3 Reference EquCab3.0 Primary Assembly

      Range
      1842209..1929249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005598012.3 → XP_005598069.2  CD44 antigen isoform X1

      UniProtKB/TrEMBL
      A0A3Q2HEJ5
      Related
      ENSECAP00000031627.2, ENSECAT00000054414.3
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    2. XM_014729352.2 → XP_014584838.2  CD44 antigen isoform X4

      UniProtKB/TrEMBL
      A0A3Q2HEJ5, A0A3Q2I011
      Related
      ENSECAP00000041076.1, ENSECAT00000032067.3
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    3. XM_023653785.1 → XP_023509553.1  CD44 antigen isoform X6

      UniProtKB/TrEMBL
      A0A3Q2HEJ5
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    4. XM_023653788.1 → XP_023509556.1  CD44 antigen isoform X11

      UniProtKB/Swiss-Prot
      Q05078
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    5. XM_014729350.2 → XP_014584836.2  CD44 antigen isoform X2

      UniProtKB/TrEMBL
      A0A3Q2HEJ5
      Conserved Domains (2) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
      cl25496
      Location:197 → 588
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    6. XM_014729351.2 → XP_014584837.2  CD44 antigen isoform X3

      UniProtKB/TrEMBL
      A0A3Q2HEJ5
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    7. XM_014729353.2 → XP_014584839.2  CD44 antigen isoform X5

      UniProtKB/TrEMBL
      A0A5F5PIX1, F6PTV7
      Related
      ENSECAP00000048453.2, ENSECAT00000077641.2
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    8. XM_005598018.3 → XP_005598075.2  CD44 antigen isoform X7

      UniProtKB/TrEMBL
      F6PTV7
      Related
      ENSECAP00000008636.2, ENSECAT00000011095.4
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    9. XM_005598019.3 → XP_005598076.2  CD44 antigen isoform X8

      UniProtKB/TrEMBL
      F6PTV7
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    10. XM_023653786.1 → XP_023509554.1  CD44 antigen isoform X9

      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    11. XM_005598023.3 → XP_005598080.2  CD44 antigen isoform X10

      UniProtKB/Swiss-Prot
      Q05078
      Conserved Domains (1) summary
      cd03516
      Location:26 → 170
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05078.1 GenPept UniProtKB/Swiss-Prot:Q05078

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