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    ipla-3 Phospholipase A(2);phospholipase A2 [ Caenorhabditis elegans ]

    Gene ID: 180354, updated on 23-Nov-2023

    Summary

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    Gene symbol
    ipla-3
    Gene description
    Phospholipase A(2);phospholipase A2
    Primary source
    WormBase:WBGene00012319
    Locus tag
    CELE_W07A8.2
    See related
    AllianceGenome:WB:WBGene00012319
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    19
    Sequence:
    Chromosome: V; NC_003283.11 (20717869..20729272, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box C protein Neighboring gene F-box domain-containing protein Neighboring gene J domain-containing protein Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling. Schmeisser S, et al. Cell Rep, 2019 Dec 24. PMID 31875559
    2. Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform. Morrison K, et al. J Biol Chem, 2012 Nov 9. PMID 23007400, Free PMC Article
    3. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phospholipase A(2);phospholipase A2
    NP_001256946.1
    • Confirmed by transcript evidence
    NP_001366900.1
    • Confirmed by transcript evidence
    NP_001367027.1
    • Confirmed by transcript evidence
    NP_001367163.1
    • Confirmed by transcript evidence
    NP_001368732.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20717869..20729272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380888.1 → NP_001366900.1  phospholipase A2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBV1
      Conserved Domains (5) summary
      cd07212
      Location:693 → 998
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      COG0666
      Location:442 → 590
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:493 → 522
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:494 → 545
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:323 → 418
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001380887.2 → NP_001367027.1  phospholipase A2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC56
      Conserved Domains (5) summary
      cd07212
      Location:691 → 996
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      COG0666
      Location:440 → 588
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:491 → 520
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:492 → 543
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:321 → 416
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001380885.1 → NP_001368732.1  phospholipase A2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WUW0
      Conserved Domains (5) summary
      cd07212
      Location:715 → 1020
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      COG0666
      Location:464 → 612
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:515 → 544
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:516 → 567
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:345 → 440
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_001380886.1 → NP_001367163.1  phospholipase A2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGD6
      Conserved Domains (5) summary
      cd07212
      Location:717 → 1022
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      COG0666
      Location:466 → 614
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:517 → 546
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:518 → 569
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:347 → 442
      Ank_2; Ankyrin repeats (3 copies)

    5. NM_001270017.3 → NP_001256946.1  Phospholipase A(2) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3Y5P2
      Conserved Domains (1) summary
      cl11396
      Location:1 → 135
      Patatin_and_cPLA2; Patatins and Phospholipases
    Nucleotide Protein
    Heading Accession and Version

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